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Nicolas Andin,Antoine Longieras,Thierry Veronese,Frédéric Marcato,Carole Molina-Jouve,Jean-Louis Uribelarrea 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.3
The production of medium chain length polyhydroxyalkanoates by Pseudomonas putida KT2440 from fatty acids leads to the loss of a large proportion of carbon. We studied the possibility of a shift of potentially available energy and carbon towards monitored residual growth during the production phase. A Fed-Batch culture achieving 125.6 g/L of total biomass containing 54.4% (g/g) of medium chain length polyhydroxyalkanoates was carried out leading to an overall experimental carbon yield of 0.7 Cmole/Cmole. The analysis of modeling fluxes deduced from experimental data indicated how carbon and reduced cofactors (NADH and FADH2) were managed to conclude that part of the carbon and reduced cofactors made available by polymer production were used in anabolic pathways. The strategy which consisted in coupled growth and medium chain length polyhydroxyalkanoate production enhanced the global yields compared to growth followed by a production phase. The understanding of carbon and energy fluxes distribution allowed deducing optimized culture strategy to perform the highest reported in the literature.
Charlotte Vaysse,Cyril Touboul,Thomas Filleron,Eliane Mery,Eva Jouve,Pierre Leguevaque,Philippe Morice,Eric Leblanc,Denis Querleu 대한부인종양학회 2011 Journal of Gynecologic Oncology Vol.22 No.1
Objective: Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim of this study was to compare the outcome stage IA-IB PCFT to a matched group of ovarian cancer (OC). Methods: Between 1990 and 2008, 32 patients with stage IA-IB of PCFT were recorded in the database of three French Institutions. A control group of patients with OC was constituted. Results: Eleven eligible PCFT cases and 29 OC controls fulfilled the stringent inclusion criteria. Median follow-up was 70.2 months. Five-year overall survival was 83.3% (95% confidence interval [CI], 27.3 to 97.5) for PCFT and 88.0% (95% CI, 66.9 to 96.0) for OC (p=0.93). In the subgroup of patients with grade 2-3, the outcome was similar in PCFT compared to OC patients (p=0.75). Five-year relapse-free survival was respectively 62.5% (95% CI, 22.9 to 86.1) and 85.0% (95% CI, 64.6 to 94.2) in the PCFT and OC groups (p=0.07). In the subgroup of patients (grade 2-3), there was no difference between PCFT and OC (p=0.65). Conclusion: The findings did not reveal any difference in prognosis between early stage of PCFT and OC when grade is taken into account. Management of PCFT should mirror that of ovarian carcinoma. Objective: Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim of this study was to compare the outcome stage IA-IB PCFT to a matched group of ovarian cancer (OC). Methods: Between 1990 and 2008, 32 patients with stage IA-IB of PCFT were recorded in the database of three French Institutions. A control group of patients with OC was constituted. Results: Eleven eligible PCFT cases and 29 OC controls fulfilled the stringent inclusion criteria. Median follow-up was 70.2 months. Five-year overall survival was 83.3% (95% confidence interval [CI], 27.3 to 97.5) for PCFT and 88.0% (95% CI, 66.9 to 96.0) for OC (p=0.93). In the subgroup of patients with grade 2-3, the outcome was similar in PCFT compared to OC patients (p=0.75). Five-year relapse-free survival was respectively 62.5% (95% CI, 22.9 to 86.1) and 85.0% (95% CI, 64.6 to 94.2) in the PCFT and OC groups (p=0.07). In the subgroup of patients (grade 2-3), there was no difference between PCFT and OC (p=0.65). Conclusion: The findings did not reveal any difference in prognosis between early stage of PCFT and OC when grade is taken into account. Management of PCFT should mirror that of ovarian carcinoma.
The variability of magnetic activity in solar‐type stars
Fabbian, D.,Simoniello, R.,Collet, R.,Criscuoli, S.,Korhonen, H.,Krivova, N. A.,Olá,h, K.,Jouve, L.,Solanki, S. K.,Alvarado‐,Gó,mez, J. D.,Booth, R.,Garcí,a, R. A.,Lehtinen, J. WILEY‐VCH Verlag GmbH Co. KGaA 2017 Astronomische Nachrichten Vol.338 No.7
<P>This article reviews the current knowledge and status of investigations on the variable magnetic activity of cool stars. We discuss the Sun in the context of solar‐type stars, highlighting peculiarities and common features in terms of its magnetic activity and variability over different time scales. We examine how both theory and observations are providing new clues about the main physical processes that generate magnetic fields in the interior of cool stars, as well as about those that lead to evolving stellar surface magnetism and varying chromospheric and coronal phenomena. We then proceed to discuss the relations between stellar age, rotation, and activity throughout the evolution of cool stars. Finally, we touch upon the importance of understanding stellar magnetism also in view of its effect on planetary environments.</P>
Nisarga, R,Premalatha, R,Shivananda,Ravikumar, K L,Shivappa, U,Gopi, A,Chikkadasarahalli, S B,Batuwanthudawe, R,Kilgore, P E,Kim, S A,Balter, I,Jouve, S,Ye, J,Moscariello, M The Academy 2015 Indian pediatrics Vol.52 No.3
<P>To estimate the incidence of invasive pneumococcal disease and pneumonia, distribution of pneumococcal serotypes, and antibiotic susceptibility in children aged 28 days to <60 months.</P>