http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : José Carlos Pinto (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Antonio Carlos Soares Pantaleão,Marcio Pinto de Castro,Krishynan Shanty Fernandes Meirelles Araujo,Carlos Frederico Ferreira Campos,André Luiz Alves da Silva,José Eduardo Ferreira Manso,João Carlos Ma 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.4
Purpose: The aim of this study was to assess the ability of ultrasound biomicroscopy (UBM) to diagnose the initial stages of nonalcoholic fatty liver disease (NAFLD) in a rat model. Methods: Eighteen male Wistar rats were allocated to control or experimental groups. A high-fat diet (HFD) with 20% fructose and 2% cholesterol, resembling a common Western diet, was fed to animals in the experimental groups for up to 16 weeks; those in the control group received a regular diet. A 21 MHz UBM system was used to acquire B-mode images at specific times: baseline (T0), 10 weeks (T10), and 16 weeks (T16). The sonographic hepatorenal index (SHRI), based on the average ultrasound image gray-level intensities from the liver parenchyma and right renal cortex, was determined at T0, T10, and T16. The liver specimen histology was classified using the modified Nonalcoholic Steatohepatitis Clinical Research Network NAFLD activity scoring system. Results: The livers in the animals in the experimental groups progressed from sinusoidal congestion and moderate macro- and micro-vesicular steatosis to moderate steatosis and frequent hepatocyte ballooning. The SHRI obtained in the experimental group animals at T10 and T16 was significantly different from the SHRI of pooled control group. No significant difference existed between the SHRI in animals receiving HFD between T10 and T16.Conclusion: SHRI measurement using UBM may be a promising noninvasive tool to characterize early-stage NAFLD in rat models.
-
Douglas Bardini Silveira,Álvaro José Celmer,Carla Maísa Camelini,Márcio José Rossi,José Carlos Cunha Petrus,Margarida Matos de Mendonça,Aguinaldo Roberto Pinto,Carlos Roberto Zanetti 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.4
Membrane technology has been applied to separate polysaccharides from Agaricus subrufescens (ASPs). The membrane-retained fractions and unfractionated preparations have been tested for in vitro immunological activity. Both the microfiltration (MF) and ultrafiltration (UF1) membranes were able to separate high-molecular weight polysaccharides from fruiting body (ASP-FB) and submerge-fermented mycelium (ASP-SmF) extracts. All fractions showed immunostimulatory effects on RAW 264.7macrophages, measured by TNF-α, iNOs gene expression,and NO production. In contrast, antibody and proliferation levels in B lymphoblastoid SKW 6.4 cells were significantly increased after treatment with ASP-FB, but did not with ASP-SmF preparations. The ASPs- and LPS-induced stimulation could be differentiated by the finding that polymyxin B, a specific inhibitor of LPS, did not significantly affect the immunoactivating response and proliferation activity of ASPs on macrophages and B cells, respectively. Furthermore, the ASP-FB treatment was unable to induce IL-6 production by B cells unlike LPS activation, sustaining distinct signaling pathways for ASP-FB and LPS. The overall results provided additional information about the action of ASPs on the immune system and support the membrane method to separate and concentrate highmolecular weight ASPs for immunopharmacological and biotechnological applications.
-
Evaluation of bioenergetic and mitochondrial function in liver transplantation
Rui Miguel Martins,João Soeiro Teodoro,Emanuel Furtado,Anabela Pinto Rolo,Carlos Marques Palmeira,José Guilherme Tralhão 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2
Background/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conducted to identify the role of bioenergetics and mitochondrial dysfunction. To the best of our knowledge, no investigation of these two factors’ impacts on liver transplantation has been performed. Methods: This was a prospective study of 28 patients who underwent liver transplantation. We measured parameters of mitochondrial function and bioenergetics in biopsies performed during the procedure. Results: We observed a statistically significant reduction in mitochondrial membrane potential, an increase in lag phase, and decreases in mitochondrial respiration and adenosine triphosphate content (P<0.010). Higher postoperative aminotransferase peaks correlated with worse mitochondrial function; mitochondrial respiration correlated with arterial lactate (P<0.010). Conclusions: There is a relationship between mitochondrial function and ischemia/reperfusion injury. The future use of these clinical markers as prognostic factors may allow early identification of post-transplant liver failure and may indicate the need to perform a new transplant.
-
Simoní Da Ros,Karen Aline Valter Flores,Marcio Schwaab,Elisa Barbosa-Coutinho,Nádia R.C. Fernandes,José Carlos Pinto 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.94 No.-
Temperature-programmed reduction (TPR) and temperature-programmed desorption (TPD) aretechniques widely used for catalyst characterization, providing information about active sites. However,results from these experiments are usually interpreted with the aid of empirical models, based on therepresentation of reduction or desorption profiles as summations of empirical reference curves. In thiscontext, phenomenological approaches can present several advantages over this traditional empiricalapproach, as in this case the extracted information can be based on theoretical models that allows for adeeper understanding of the catalyst properties. For this reason, in the present work, empirical andphenomenological modelling approaches are evaluated for the quantitative analysis of H2-TPR and NH3-TPD profiles, obtained from the characterization of Ni/SiO2 and Al2O3 alumina catalysts, respectively, andresults from both approaches are thoroughly compared and discussed for thefirst time. Our results,obtained from thefitting of both modelling approaches to the whole experimental profile by usingnonlinear regression, indicate that the phenomenological modelling approach can be considered betterand should therefore be preferred, as it allows for significantly more accurate quantification and correctdiscrimination of distinct active sites, in addition to simultaneously enabling the determination ofreduction or desorption kinetics parameters.
KCI
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
