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      • Culture-independent Identification of Bacterial Contamination in Inhaler Devices Used for One Month by Patients with Airway Diseases

        ( Jiyeon Baek ),( Ok Joo Sul ),( Jimi Oh ),( Hayoung Choi ),( Hyun Lee ),( Yeon-mok Oh ),( Byungsuk Kwon ),( Kwang Won Seo ),( Yangjin Jegal ),( Seung Won Ra ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

        Background Metered-dose inhaler (MDI) and RESPIMAT devices, in liquid drug formulations, are widely used and monthly based for patients with airway diseases. Bacterial contaminations in the inhaler devices have been examined by culture-based method which cannot detect dead or unculturable bacteria. This study aimed to investigate the contamination of inhaler canisters after a month of use with 16s rRNA gene-based sequencing and the difference of bacterial composition between MDI and RESPIMAT devices. Methods Twelve inhalers (6 MDI and 6 RESPIMAT) used for 30 days by 10 patients (2 patients used both inhalers) were collected as the experimental group; new inhalers were the control (11 MDI and 9 RESPIMAT). DNA was extracted from the remaining liquid formulations in the dismantled devices; absolute quantitative PCR was performed using 16S rRNA to measure the total bacterial load. Microbiome taxonomic profiling based on 16S rRNA sequencing analysis was used to determine the microbial community composition using an Ezbiocloud database. Results The total bacterial load in both inhaler types increased significantly after one month of use (p=0.004), suggesting inhaler contamination; there was no difference in bacterial load increase between MDI and RESPIMAT. Diversity analyses of the inhaler microbiomes showed no significant differences. There were more prevalent large-sized bacilli in MDI than RESPIMAT, whereas small-sized symbiotic cocci contaminated both devices after a month of use. We were able to replicate the findings in patients using both inhalers: MDI showed higher percentages of large-sized bacilli versus RESPIMAT devices (Haemophilus, 34.6% vs. 14.6%; Pseudomonas, 11.94% vs. <1%), whereas the percentage of small-sized cocci was comparable (6.7% vs. 8.2%) Conclusions The bacterial load identified through culture-independent 16s rRNA gene-based sequencing revealed that inhalers used for a month were contaminated. The two devices showed different bacterial compositions, possibly due to differences in the drug pathway pore size in RESPIMAT devices.

      • KCI등재

        Corrosive Esophageal Injury due to a Commercial Vinegar Beverage in an Adolescent

        Jiyeon Chang,Sang-eun Han,백승삼,Yong Joo Kim 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.3

        Although gastroesophageal damage is commonly induced by accidental drinking of a strong acid or alkali, damage due to the consumption of a vinegar beverage is not well known. We report a case of corrosive esophageal ulcer found in an adolescent consuming vineagr drink daily. A 15-year-old male visited the emergency room presenting with hematemesis and severe epigastric pain. Multiple longitudinal ulcers, concurrent mucosal hemorrhage, and denuded mucosa were noted in the whole of the esophagus via and endoscopic examination. He had been drinking a vinegar beverage daily without sufficient dilution. The patient was treated with corticosteroid, antibiotic therapy, and mucosa protecting alginate medication and was asked to fast for a week. The follow-up endoscopy showed improvement of the esophageal injuries. Overall, continuous consumption of a vinegar beverage can result in acidic burns and desturction of the surface of the upper gastrointestinal tract. Therefore, vinegar beverages should be considered as corrosive agentes.

      • One-Step Synthesis of Cross-Linked Ionic Polymer Thin Films in Vapor Phase and Its Application to an Oil/Water Separation Membrane

        Joo, Munkyu,Shin, Jihye,Kim, Jiyeon,You, Jae Bem,Yoo, Youngmin,Kwak, Moo Jin,Oh, Myung Seok,Im, Sung Gap American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.6

        <P>In spite of the huge research interest, ionic polymers could not have been synthesized in the vapor phase because the monomers of ionic polymers contain nonvolatile ionic salts, preventing the monomers from vaporization. Here, we suggest a new, one-step synthetic pathway to form a series of cross-linked ionic polymers (CIPs) in the vapor phase via initiated chemical vapor deposition (iCVD). 2(Dimethylamino) ethyl methacrylate (DMAEMA) and 4-vinylbenzyl chloride (VBC) monomers are introduced into the iCVD reactor in the vapor phase to form a copolymer film. Simultaneously in the course of the deposition process, the tertiary amine in DMAEMA and benzylic chloride in VBC undergo a Menshutkin nucleophilic substitution reaction to form an ionic ammonium chloride,complex, forming a highly cross linked ionic copolymer film of p(DMAEMA-co-VBC). To the best of our knowledge, this is the first report on the synthesis of CIP films in the vapor phase. The newly developed CIP thin film is further applied to the surface modification of the membrane for oil/water separation. With the hydrophilic and underwater oleophobic membrane whose surface is modified with the CIP film, excellent separation efficiency (>99%) and unprecedentedly high permeation flux (average 2.32 X 10(5) L m(-2) h(-1)) are achieved.</P>

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      • KCI등재

        통합모델의 강수물리과정 모수 최적화를 위한 알고리즘 비교 연구

        장지연(Jiyeon Jang),이용희(Yong Hee Lee),주상원(Sangwon Joo) 한국지능시스템학회 2017 한국지능시스템학회논문지 Vol.27 No.1

        기상수치예보모델의 강수물리과정은 강수 발생과 연관된 입자의 낙하속도, 부착 및 자동전환, 입자크기분포 등의 과정을 다룬다. 하지만 수치예보모델의 미세물리과정과 모수에는 상당한 불확실성이 내포되어 있다. 수치예보모델의 불확실성을 줄이기 위하여 일반적으로 모수 추정을 사용한다. 이 연구에서는 모수 추정을 위한 최적화 알고리즘으로 마이크로 유전알고리즘과 하모니탐색 알고리즘을 사용하고 우리나라에서 발생한 강수사례에 대해 통합모델의 강수물리과정에서 사용하는 모수를 최적화하였다. 두 알고리즘의 서로 다른 특성으로 인해 최적화 과정 중의 차이가 보였다. 마이크로 유전알고리즘은 440회 수행 후 약 1.033의 적합도로 수렴하였고 하모니탐색 알고리즘은 60번 수행 후 약 1.031의 적합도로 수렴하였다. 이를 통해 하모니탐색 알고리즘이 마이크로 유전알고리즘보다 더 빨리 최적의 모수를 탐색하는 것을 알 수 있었다. 따라서 계산비용이 방대한 기상수치예보모델의 최적화 문제에서 빠른 시간 내에 최적의 모수를 탐색해야 한다면 하모니 탐색 알고리즘이 더 적합하다는 것을 확인하였다. The microphysical processes of the numerical weather prediction (NWP) model cover the following : fall speed, accretion, autoconversion, droplet size distribution, etc. However, the microphysical processes and parameters have a significant degree of uncertainty. Parameter estimation was generally used to reduce errors in NWP models associated with uncertainty. In this study, the micro- genetic algorithm and harmony search algorithm were used as an optimization algorithm for estimating parameters. And we estimate parameters of microphysics for the Unified model in the case of precipitation in Korea. The differences which occurred during the optimization process were due to different characteristics of the two algorithms. The micro-genetic algorithm converged to about 1.033 after 440 times. The harmony search algorithm converged to about 1.031 after 60 times. It shows that the harmony search algorithm estimated optimal parameters more quickly than the micro-genetic algorithm. Therefore, if you need to search for the optimal parameter within a faster time in the NWP model optimization problem with large calculation cost, the harmony search algorithm is more suitable.

      • KCI등재

        대학의 성인학습자 대상 의사소통교육체제 분석

        주민재(Joo, Minjae),연지연(Yeon, Jiyeon),이현주(Lee, Hyunju) 한국성인교육학회 2021 Andragogy Today : International Journal of Adult & Vol.24 No.3

        본 연구의 목적은 국내 각 대학의 성인학습자 대상 의사소통교육의 현황과 교수자 및 행정 담당자의 인식을 분석하여, 성인학습자에게 적합한 의사소통 교육 방법과 교수학습 전략을 구축하기 위한 자료를 확보하는 데 있다. 이를 위해 <대학의 평생교육체제 지원 사업> 참여 대학이 운영하고 있는 의사소통교육 현황에 대한 기초설문조사와 교수자, 행정 담당자를 대상으로 인터뷰를 실시하여 각 대학의 성인학습자 대상 의사소통교육 운영 현황 및 담당자 인식을 분석하였다. 설문조사결과에 따르면 각 대학의 성인학습자 대상 의사소통교육은 대부분 학령기 학습자 대상으로 운영되는 의사소통교육체제를 준용하고 있었다. 일부 대학에서만 의사소통 교과목을 미래융합대학 상황에 맞춰 유연하게 운용하고 있었다. 각 대학의 의사소통교육 운영 현황에 대한 심층 인터뷰 결과에 따르면, 현재 성인학습자 의사소통교육은 학부 교육과정과의 차별화 미흡과 특성화 부족으로 요약된다. 의사소통 역량 향상을 위한 성인학습자 대상의 별도 지원체계 역시 미흡하였다. 인터뷰 참여자들은 성인학습자들의 특성을 고려하지 않은 학사 운영 등으로 학습자들의 실제 요구에 부합되지 않는 형태로 의사소통교육이 운영되고 있으며 성인학습자 맞춤형 커리큘럼 및 콘텐츠가 시급히 개발되어야 한다고 인식하고 있었다. 따라서 본 연구에서는 성인학습자 대상 의사소통교육의 내실화를 위해 성인학습자 요구 맞춤형 운영이 가능한 트랙제 교육과정과 성인학습자의 수준 및 경험을 고려한 교육 내용과 자료 개발이 필요하며 이를 위해서는 성인학습자의 의사소통교육을 전담하는 전임교원의 확보가 핵심적인 과제라는 것을 제시하였다. The purpose of this study is to analyze the current status of communication education for adult learners at each university in Korea and the perceptions of teachers and administrators, and to secure data for establishing communication education methods and teaching and learning strategies suitable for adult learners.. The researchers conducted a basic survey on the status of communication education operated by universities participating in the <LiFE project> in Korea and conducted interviews with professors and administrators. The current status of communication education for adult learners at each university and the perception of the person in charge were analyzed. According to the survey results, most of the communication education for adult learners of each university applied the communication education system operated for school-age learners mutatis mutandis. According to an in-depth interview on the current status of communication education operation at each university, communication education for adult learners was insufficiently differentiated from the undergraduate curriculum and lacked specialization. In addition, a separate support system for adult learners to improve communication competency is insufficient. Participants recognized that communication education was being operated in a form that did not meet the actual needs of learners due to academic operation that did not take into account the characteristics of adult learners, and that curriculum and contents customized for adult learners should be developed urgently. Therefore, in this study, it is argued that, in order to substantiate communication education for adult learners, it is urgently necessary to develop a track-based curriculum that can be operated tailored to the needs of adult learners, and educational contents and materials that consider the level and experience of adult learners. In addition, for this purpose, each university proposes as a core task to secure a full-time faculty in charge of communication education for adult learners.

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