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청갓과 적갓에 함유된 Glucosinolates의 항암 활성 및 정량 분석
김활 ( Hwal Kim ),김준열 ( Jun Yeol Kim ),김효진 ( Hyo Jin Kim ),김도경 ( Do Kyung Kim ),조혜진 ( Hye Jin Jo ),한병수 ( Byoung Su Han ),김헌웅 ( Heon Woong Kim ),김정봉 ( Jung Bong Kim ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.3
The objective of this study was to compare the anticancer activity of glucosinolates against four different cancer cells; SNU-251, SNU-354, SNU-C4, MCF-7 and to determine the amounts of glucosinolates in mustard leaves. Green and red mustard leaves were cultivated on the field of Rural Development Administration from May to July, 2010. After the leaves were harvest and lypophilized, the fine powder was extracted with boiling 70% methanol(v/v) for the measurement of anticancer activity and then applied to the cancer cells obtained from Korean Cell Line Bank(KCLB). The anticancer activity of red leaf mustard was higher than that of green mustard leaf, particularly in SNU-251 for 24 hr and in SNU-C4 for 48 hr. In both green and red mustard leaf, sinigrin was the most abundant glucosinolte and was determined as 4.71 and 3.06 ㎎/g dry wt., respectively, but glucoiberin only presented 0.14 ㎎/g dry wt. with minor amounts.
Kim, Han Young,Kumar, Hemant,Jo, Min-Jae,Kim, Jonghoon,Yoon, Jeong-Kee,Lee, Ju-Ro,Kang, Mikyung,Choo, Yeon Woong,Song, Seuk Young,Kwon, Sung Pil,Hyeon, Taeghwan,Han, In-Bo,Kim, Byung-Soo American Chemical Society 2018 NANO LETTERS Vol.18 No.8
<P>Human mesenchymal stem cell (hMSC)-derived exosomes have been spotlighted as a promising therapeutic agent for cell-free regenerative medicine. However, poor organ-targeting ability and insufficient therapeutic efficacy of systemically injected hMSC-exosomes were identified as critical limitations for their further applications. Therefore, in this study we fabricated iron oxide nanoparticle (IONP)-incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs and evaluated their therapeutic efficacy in a clinically relevant model for spinal cord injury. Compared to exosome-mimetic nanovesicles (NV) prepared from untreated hMSCs, NV-IONP not only contained IONPs which act as a magnet-guided navigation tool but also carried greater amounts of therapeutic growth factors that can be delivered to the target cells. The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs. In vivo systemic injection of NV-IONP with magnetic guidance significantly increased the amount of NV-IONP accumulating in the injured spinal cord. Accumulated NV-IONP enhanced blood vessel formation, attenuated inflammation and apoptosis in the injured spinal cord, and consequently improved spinal cord function. Taken together, these findings highlight the development of therapeutic efficacy-potentiated extracellular nanovesicles and demonstrate their feasibility for repairing injured spinal cord.</P> [FIG OMISSION]</BR>
Acid-Assisted Ligand Exchange Enhances Coupling in Colloidal Quantum Dot Solids
Jo, Jea Woong,Choi, Jongmin,Garcí,a de Arquer, F. Pelayo,Seifitokaldani, Ali,Sun, Bin,Kim, Younghoon,Ahn, Hyungju,Fan, James,Quintero-Bermudez, Rafael,Kim, Junghwan,Choi, Min-Jae,Baek, Se-Woong American Chemical Society 2018 NANO LETTERS Vol.18 No.7
<P>Colloidal quantum dots (CQDs) are promising solution-processed infrared-absorbing materials for optoelectronics. In these applications, it is crucial to replace the electrically insulating ligands used in synthesis to form strongly coupled quantum dot solids. Recently, solution-phase ligand-exchange strategies have been reported that minimize the density of defects and the polydispersity of CQDs; however, we find herein that the new ligands exhibit insufficient chemical reactivity to remove original oleic acid ligands completely. This leads to low CQD packing and correspondingly low electronic performance. Here we report an acid-assisted solution-phase ligand-exchange strategy that, by enabling efficient removal of the original ligands, enables the synthesis of densified CQD arrays. Our use of hydroiodic acid simultaneously facilitates high CQD packing via proton donation and CQD passivation through iodine. We demonstrate highly packed CQD films with a 2.5 times increased carrier mobility compared with prior exchanges. The resulting devices achieve the highest infrared photon-to-electron conversion efficiencies (>50%) reported in the spectral range of 0.8 to 1.1 eV.</P> [FIG OMISSION]</BR>
Sinterability of Low-Cost 3Y-ZrO<sub>2</sub> Powder and Mechanical Properties of the Sintered Body
Kim, Min-Sung,Go, Shin-Il,Kim, Jin-Myung,Park, Young-Jo,Kim, Ha-Neul,Ko, Jae-Woong,Jung, Seung-Hwa,Kim, Jae-Yuk,Yun, Jon-Do The Korean Ceramic Society 2017 한국세라믹학회지 Vol.54 No.4
This study investigated the effects of grain size and phase constitution on the mechanical properties of $3Y-ZrO_2$ by varying the sintering conditions. The raw powder prepared by a low-cost wet milling using the coarse solid oxide powders was sintered by both pressureless sintering and hot-pressing, respectively. As increasing holding time at $1450^{\circ}C$ for pressureless sintering, it promoted the microstructural coarsening of matrix grains and the phase transformation to tetragonal phase, whereas the bimodal microstructure embedded with abnormal $cubic-ZrO_2$ grains was observed regardless of sintering time. On the other hand, the specimens hot-pressed at $1300^{\circ}C$ for 2 h reached ~ 97% of relative density with homogeneous fine microstructure and mixed phase constitution. It was found that the proportion of untransformed monoclinic zirconia had the most adverse effect on the biaxial strength compared to the impacts of grain size and density. The pressureless sintering of the low-cost powder for prolonged sintering time to 8 h led to a decent combination of mechanical properties ($H_V=13.2GPa$, $K_{IC}=8.16MPa{\cdot}m^{1/2}$, ${\sigma}=981MPa$).
Fretting-Wear Characteristics of Steam Generator Tubes by Foreign Object
Jo Jong Chull,Jhung Myung Jo,Kim Woong Sik,Choi Young Hwan,Kim Hho Jung,Kim Tae Hyung Korean Nuclear Society 2003 Nuclear Engineering and Technology Vol.35 No.5
This study investigates the safety assessment of the potential for fretting-wear damages on steam generator (SG) U-tubes caused by foreign object in operating nuclear power plants. The operating SG shell-side flow field conditions are obtained from three-dimensional SG flow calculation using the ATHOS3 code. Modal analyses are performed for the finite element modelings of U-tubes to get the natural frequency, corresponding mode shape and participation factor. The wear rate of U-tube caused by foreign object is calculated using the Archard formula and the remaining life of the tube is predicted. Also, discussed in this study is the effect of the flow velocity and vibration of the tube on the remaining life of the tube.
Woong Rae Jo,Chang Young Lee,Sae Min Kwon,Chang Hyun Kim,Min Yong Kwon,Jae Hyun Kim,Young San Ko 대한신경손상학회 2023 Korean Journal of Neurotrauma Vol.19 No.4
Objective: Odontoid fractures are treated surgically through the anterior or posterior approach. Each surgical approach has its advantages and disadvantages, so the preferred approach remains debatable. There are few meta-analyses or systemic reviews on the mechanical complications of surgical treatment for odontoid fractures. This meta-analysis aimed to compare the operation-related morbidity, including mechanical complications, and mortality of patients with odontoid fractures, treated via the anterior or posterior approach. Methods: A systematic search was performed on PubMed/Medline, Embase, and the Cochrane Library for the studies up to October 2023 on the complication rate of the surgical treatment of odontoid fractures, related to the surgical approach. The risk ratios (RR) with the 95% confidence intervals (CIs) were pooled to assess the mechanical complication rates, other complications, revision surgery, and mortality, depending on the surgical approach. Results: A total of 1,519 studies were retrieved using the search strategy, and 782 patients from 15 articles were included in this meta-analysis. Mechanical complications were significantly more frequent in the anterior surgical group with low heterogeneity. The incidences of fracture nonunion and revision surgery were also higher in the anterior surgery group. However, there was no significant difference in systemic complications and mortality rates between the two groups. Conclusion: The posterior approach was more advantageous than the anterior approach in terms of mechanical complications, fusion rates, and incidence of revision surgery. However, further studies, should be performed to strengthen these results.
Kim, Su Jin,Kim, Kyeong Heon,Chung, Ho Young,Shin, Hee Woong,Lee, Byeong Ryong,Jeong, Tak,Park, Hyung Jo,Kim, Tae Geun Optical Society of America 2014 Optics letters Vol.39 No.12
<P>We investigated GaN-based vertical light-emitting diodes (VLEDs) with periodic and conical nanopillar arrays (CNAs) to improve the light-output efficiency. We found that a 470?nm diameter and 0.8-0.9?μm height increased the light output, and the devices suffered no significant electrical property degradations. The light-output power was 272% and 5.1% greater than flat- and rough-surface VLEDs at 350?mA, respectively. These improved optical properties are attributed to the optimized CNAs, which increase the effective photon escape cone and reduce the total internal reflection at the n-GaN-air interface. We also investigated the emission characteristics and mechanisms with finite-difference time-domain simulations.</P>
Effects of microstructure and intergranular glassy phases on thermal conductivity of silicon nitride
Kim, Jin-Myung,Ko, Sin-Il,Kim, Ha-Neul,Ko, Jae-Woong,Lee, Jae-Wook,Kim, Hai-Doo,Park, Young-Jo Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.7
<P><B>Abstract</B></P> <P>In this study, the binary sintering additives Y<SUB>2</SUB>O<SUB>3</SUB>-Sc<SUB>2</SUB>O<SUB>3</SUB>, were first applied to the Si<SUB>3</SUB>N<SUB>4</SUB> system to investigate their effects on microstructure and thermal conductivity. The microstructure and thermal conductivity of both sintered silicon nitride (SSN) and sintered reaction-bonded silicon nitride (SRBSN) were found to be significantly dependent on the additive composition. Among various combinations of Y<SUB>2</SUB>O<SUB>3</SUB> and Sc<SUB>2</SUB>O<SUB>3</SUB>, 1mol% Y<SUB>2</SUB>O<SUB>3</SUB>−3mol% Sc<SUB>2</SUB>O<SUB>3</SUB> prominently enhanced thermal conductivity, and the enhancement could not be attributed to any difference in microstructure or lattice defects. TEM observation revealed that this composition was more liable to devitrify the glassy phase with a lower degree of stress accumulation, and to possibly produce a grain boundary that was cleaner or with a higher order of atomic arrangement. A microstructure model for thermal conductivity was proposed which took the thermal resistance of the grain boundaries into account. The grain boundary state exerted a remarkable influence on the thermal conductivity of fine microstructures, and the experimentally measured thermal conductivity values were consistent with those given by the proposed model.</P>