Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

( Yichuan Xiao ),( Jin Jin ),( Mikyoung Chang ),( Jae Hoon Chang ),( Hongbo Hu ),( Xiaofei Zhou ),( George C Brittain ),( Christine Stansberg ),( Qivind Torkildsen ),( Xiaodong Wang ),( Robert Brink ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

Microglia are crucial for the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Here we show that the E3 ubiquitin ligase Peli1 is abundantly expressed in microglia and promotes microglial activation during the course of EAE induction. Peli1mediates the induction of chemokines and proinflammatory cytokines in microglia and therebypromotes recruitment of T cells into the central nervous system. The severity of EAE is reduced inPeli1-deficient mice despite their competent induction of inflammatory T cells in the peripheral lymphoid organs. Notably, Peli1 regulates Toll-like receptor (TLR) pathway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhibitor of mitogen-activated protein kinase (MAPK) activation and gene induction. Ablation of Traf3 restores microglial activation and CNS inflammation after the induction of EAE in Peli1-deficient mice. These findings establish Peli1 as a microglia-specific mediator of autoimmune neuroinflammation and suggest a previously unknown signaling mechanism of Peli1 function.

Blind signal separation for coprime planar arrays: An improved coupled trilinear decomposition method

Zhongyuan Que,Xiaofei Zhang,Benzhou Jin Electronics and Telecommunications Research Instit 2023 ETRI Journal Vol.45 No.1

In this study, the problem of blind signal separation for coprime planar arrays is investigated. For coprime planar arrays comprising two uniform rectangular subarrays, we link the signal separation to the tensor-based model called coupled canonical polyadic decomposition (CPD) and propose an improved coupled trilinear decomposition approach. The output data of coprime planar arrays are modeled as a coupled tensor set that can be further interpreted as a coupled CPD model, allowing a signal separation to be achieved using coupled trilinear alternating least squares (TALS). Furthermore, in the procedure of the coupled TALS, a Vandermonde structure enforcing approach is explicitly applied, which is shown to ensure fast convergence. The results of Monto Carlo simulations show that our proposed algorithm has the same separation accuracy as the basic coupled TALS but with a faster convergence speed.

A Multicast Based Bandwidth Saving Approach for Wireless Live Streaming System

Wenbin Jiang,Hai Jin,Xiaofei Liao,Zhi Yuan 보안공학연구지원센터 2008 International Journal of Smart Home Vol.2 No.1

P2P based live streaming applications are growing up rapidly. However, when extending them to WLANs, the bandwidth bottleneck and the high rate of packet loss are usually the major stumbling blocks. To overcome this issue, a new wireless multicast agent mechanism (WiMA) based on the IP multicast scheme for buffer management and scheduling is proposed. First of all, a wireless agent selection method is presented to choose an appropriate agent for WiMA. Then this agent gains media data by interacting with wired neighbor peers as a common P2P node, and transmits these data to other wireless peers in the WLAN by means of multicast pushing and multicast patching. A normal wireless peer requests data according to the strategy of "emergent ones first". Experimental results show that the approach proposed can significantly save bandwidth in WLANs with acceptable start delay and satisfied playing continuity.

Prognostic Evaluation of Nasopharyngeal Carcinoma with Bone-Only Metastasis after Therapy

Jianji Pan,Tianzhu Lu,Qiaojuan Guo,Xiaofei Cui,Zhuhong Chen,Shaojun Lin,Luying Xu,Jin Lin,Jingfeng Zong 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4

Purpose: To evaluate the prognosis of nasopharyngeal carcinoma (NPC) patients who developed bone-only metastasis after primarytreatment and the stratification of these patients into different risk groups based on independent prognostic factors. Materials and Methods: Eighty NPC patients who developed bone-only metastasis after definitive radiotherapy from October 2005to December 2010 were enrolled. All these patients received palliative treatment for bone metastasis, including chemotherapyand/or radiotherapy. Clinical features, treatment modality, and laboratory parameters were examined with univariate and multivariateanalyses. Results: The median follow-up time was 15.5 months (range, 2–67 months) for the whole cohort. The median overall metastaticsurvival (OMS) time and the 2-year estimate OMS rate were 26.5 months and 52%, respectively. Multivariate analysis indicated thatpatients with short metastases-free interval, multiple bone metastases sites, high serum lactic dehydrogenase levels, and treatedwith radiotherapy or chemotherapy alone had significantly worse outcomes. Patients were stratified into three different risk groupsbased on the number of adverse factors present. The OMS curves of the three groups were all significantly different (p<0.001). Conclusion: Severl prognostic factors were found to be associated with worse outcomes. According to the number of adverse factorspresent, bone-only metastasis patients can be stratified into three risk groups with significantly different prognoses. Suchgrouping may help in improving the design of clinical trials and in guiding individualized treatment for NPC patients with boneonlymetastasis.

Exploiting Anti-T-shaped Graphene Architecture to Form Low Tortuosity, Sieve-like Interfaces for High-Performance Anodes for Li-Based Cells

Wang, Dong,Zhang, Wei,Drewett, Nicholas E.,Liu, Xiaofei,Yoo, Seung Jo,Lee, Sang-Gil,Kim, Jin-Gyu,Deng, Ting,Zhang, Xiaoyu,Shi, Xiaoyuan,Zheng, Weitao American Chemical Society 2018 ACS central science Vol.4 No.1

<▼1><P/><P>Graphitic carbon anodes have long been used in Li ion batteries due to their combination of attractive properties, such as low cost, high gravimetric energy density, and good rate capability. However, one significant challenge is controlling, and optimizing, the nature and formation of the solid electrolyte interphase (SEI). Here it is demonstrated that carbon coating via chemical vapor deposition (CVD) facilitates high electrochemical performance of carbon anodes. We examine and characterize the substrate/vertical graphene interface (multilayer graphene nanowalls coated onto carbon paper via plasma enhanced CVD), revealing that these low-tortuosity and high-selection graphene nanowalls act as fast Li ion transport channels. Moreover, we determine that the hitherto neglected parallel layer acts as a protective surface at the interface, enhancing the anode performance. In summary, these findings not only clarify the synergistic role of the parallel functional interface when combined with vertical graphene nanowalls but also have facilitated the development of design principles for future high rate, high performance batteries.</P></▼1><▼2><P>We explored an anti-T-shaped graphene surface-coating concept which offers a low-tortuosity, sieve-like interface that may be exploited for optimized Li-based anodes.</P></▼2>

Static and Seismic Experimental Study of Novel Prefabricated Beam-Column Joints with Elongated-Hole Brackets

Zhang Zhiwei,Li Dong,Wang Huajie,Li Songling,Qian Hongliang,Bi Yanhua,Wang Guoxing,Jin Xiaofei,Fan Feng 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.1

To enhance the structural connectivity of prefabricated steel frame systems and augment their construction effi ciency, this study introduces an innovative prefabricated joint design tailored for square steel columns and H-beams characterized by varying beam heights. This study includes both static loading tests and seismic tests performed on full-scale joints featuring two diff erent beam heights. This investigation involved a comprehensive analysis of the static and seismic performance of the joints, employing various performance metrics such as ultimate load capacities, ultimate rotation angles, hysteresis curves, skeleton curves, stiff ness degradation curves, and ductility coeffi cients, in alignment with established structural codes and standards. The results indicate that the plasticity of the H-beam is fully developed, exhibiting a relative slip phenomenon. Additionally, the joints demonstrate commendable rotational capacity, with hysteresis curves consistently manifesting an inverse S-shape and exhibiting noteworthy stiff ness degradation. Furthermore, the comparison with the unimproved joint shows that the novel joint, in addition to being easy to construct, has better ductility and energy dissipation capacity. The results of the study will provide a technical reference for further optimization and application of prefabricated beam-column joints.