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Jianming Xu,Mingxuan Sun,Li Yu 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.2
This paper addresses the synthesis of an iterative learning controller for a class of linear systems with norm-bounded parameter uncertainties. We take into account an iterative learning algorithm with current cycle feedback in order to achieve both robust convergence and robust stability. The synthesis problem of the developed iterative learning control (ILC) system is reformulated as the γ-suboptimal H∞ control problem via the linear fractional transformation (LFT). A sufficient convergence condition of the ILC system is presented in terms of linear matrix inequalities (LMIs). Furthermore, the ILC system with fast convergence rate is constructed using a convex optimization technique with LMI constraints. The simulation results demonstrate the effectiveness of the proposed method.
Jianming Hua,Ning Shen,Jingkai Wang,Yiqing Tao,Fangcai Li,Qixin Chen,Xiaopeng Zhou 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.9
Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of the small molecule SAG. The NP-specific differentiation and extracellular matrix (ECM) synthesis of ADSCs were measured in vitro, and the regenerative effects of SAG pretreated ADSCs in degenerated IVDs were verified in vivo. The results showed that the combination of SAG and transforming growth factor-β3 (TGF-β3) is able to increase the ECM synthesis of ADSCs. In addition, the gene and protein expression levels of NP-specific markers were increased by treatment with SAG and TGF-β3. Furthermore, SAG pretreated ADSCs can also improve the disc height, water content, ECM content, and structure of degenerated IVDs in vivo. Our new differentiation scheme has high efficiency in inducing NP-specific differentiation of ADSCs and is promising for stem cell-based treatment of degenerated IVDs.
H<SUB>∞</SUB> Control of 2-D Discrete State Delay Systems
Jianming Xu,Li Yu 대한전기학회 2006 International Journal of Control, Automation, and Vol.4 No.4
This paper is concerned with the H∞ control problem of 2-D discrete state delay systems described by the Roesser model. The condition for the system to have a specified H∞ performance is derived via the linear matrix inequality (LMI) approach. Furthermore, a design procedure for H∞ state feedback controllers is given by solving a certain LMI. The design problem of optimal H∞ controllers is formulated as a convex optimization problem, which can be solved by existing convex optimization techniques. Simulation results are presented to illustrate the effectiveness of the proposed results.
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
Zhang, Jianming,Adriá,n, Francisco J.,Jahnke, Wolfgang,Cowan-Jacob, Sandra W.,Li, Allen G.,Iacob, Roxana E.,Sim, Taebo,Powers, John,Dierks, Christine,Sun, Fangxian,Guo, Gui-Rong,Ding, Qiang,Okra Macmillan Publishers Limited. All rights reserved 2010 Nature Vol.463 No.7280
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr–Abl, we recently reported the discovery of GNF-2, a selective allosteric Bcr–Abl inhibitor. Here, using solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange mass spectrometry, we show that GNF-2 binds to the myristate-binding site of Abl, leading to changes in the structural dynamics of the ATP-binding site. GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, when used in combination with the ATP-competitive inhibitors imatinib or nilotinib, suppressed the emergence of resistance mutations in vitro, displayed additive inhibitory activity in biochemical and cellular assays against T315I mutant human Bcr–Abl and displayed in vivo efficacy against this recalcitrant mutant in a murine bone-marrow transplantation model. These results show that therapeutically relevant inhibition of Bcr–Abl activity can be achieved with inhibitors that bind to the myristate-binding site and that combining allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.
Jiayang Li,Lewei Tong,Jianming Wu,Yeming Pan 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.8
The wind pressure distribution on the photovoltaic (PV) array is of great importance to the wind resistance design. The flow field related to the pressure can be influenced significantly by the turbulence induced by the building roof edge (Kopp et al., 2012) and it is essential to consider the building effect during the investigation. However, most CFD (computational fluid dynamics) investigations of wind pressure distribution on the PV array are limited to ground mounted PV array without the building. There is a necessity to extend the application of CFD method to flows around roof-mounted PV array. This study investigated the wind pressure distributions on PV arrays mounted on building roofs by means of Reynolds-averaged Navier–Stokes (RANS) approach using the FLUENT software. Since RANS models are sensitive to the flow condition, several RANS models are adopted and the most accurate RANS model for predicting this type of flow is identified based on a comparison with the wind tunnel experimental results. The SST k-ω model can predict the highest net mean wind uplift located at panels upstream accurately and is further applied for the parameter analysis to facilitate the installation of roof-mounted PV array. Numerical simulations of the wind flow field for wind angles between 0° to 180° were carried out at intervals of 20°, and the resulted net pressure distributions were presented. The influences of tilt angles of the PV array were investigated and the pressure distributions of PV panels were related to the flow field. Moreover, the effects of clearance between the PV array and building roof on the flow fields and pressure distributions of the PV array related to PV array tilt angle are studied.
Hua, Jianming,Shen, Ning,Wang, Jingkai,Tao, Yiqing,Li, Fangcai,Chen, Qixin,Zhou, Xiaopeng Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.9
Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising for regenerating degenerated intervertebral discs (IVDs), but the low efficiency of nucleus pulposus (NP)-specific differentiation limits their clinical applications. The Sonic hedgehog (Shh) signaling pathway is important in NP-specific differentiation of ADSCs, and Smoothened Agonist (SAG) is a highly specific and effective agonist of Shh signaling. In this study, we proposed a new differentiation strategy with the use of the small molecule SAG. The NP-specific differentiation and extracellular matrix (ECM) synthesis of ADSCs were measured in vitro, and the regenerative effects of SAG pretreated ADSCs in degenerated IVDs were verified in vivo. The results showed that the combination of SAG and transforming growth factor-${\beta}3$ ($TGF-{\beta}3$) is able to increase the ECM synthesis of ADSCs. In addition, the gene and protein expression levels of NP-specific markers were increased by treatment with SAG and $TGF-{\beta}3$. Furthermore, SAG pretreated ADSCs can also improve the disc height, water content, ECM content, and structure of degenerated IVDs in vivo. Our new differentiation scheme has high efficiency in inducing NP-specific differentiation of ADSCs and is promising for stem cell-based treatment of degenerated IVDs.
Gao, Wen,Li, Jianming,Cirillo, John,Borgens, Richard,Cho, Youngnam American Chemical Society 2014 Langmuir Vol.30 No.26
<P/><P>In this work, we introduce a free-standing, vertically aligned conductive polypyrrole (Ppy) architecture that can serve as a high-capacity drug reservoir. This novel geometric organization of Ppy provides a new platform for improving the drug-loading efficiency. Most importantly, we present the first formal evidence that an impregnated drug (dexamethasone, DEX) can be released on demand by a focal, pulsatile electromagnetic field (EMF). This remotely controlled, on–off switchable polymer system provides a framework for implantable constructs that can be placed in critical areas of the body without any physical contact (such as percutaneous electrodes) with the Ppy, contributing to a low “foreign body” footprint. We demonstrate this possibility by using a BV-2 microglia culture model in which reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) expression was attenuated in response to DEX released from EMF-stimulated Ppy.</P>
Monoecism Algorithm in the Application of E-commerce Information Security
Qingjie Zhang,Jianming Zhu,Xiaoxu Wang,Yapan Li 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.3
With the development of e-commerce industry, the security of business information has attracted a lot of attention. The paper [1] puts forward the monoecism watermarking algorithm. The algorithm divides image into two parts: ROI (Region of interest) and RONI (Region Of Non Interest), and respectively deal with the two parts. Female watermark and male watermark are embedded into the RONI at the same time, and generate embedding watermark of the image. As is known to all, the integrity of ROI is also very important in e-commerce. This paper tries to apply the monoecism watermarking algorithm to e-commerce information security. The author gives six applications of the algorithm in electronic commerce that is graphical physical paper, electronic paper anti-counterfeiting, electronic seal, copyright protection, digital fingerprint generation, secure communication protection. This author introduced the embedding watermark and extracting watermark process and detection process of monoecism watermark algorithm. Through the analysis of simulation experiment of six application fields of monoecism watermark algorithm in the e-commerce information security, the simulation experiment has verified the validity of the algorithm. In a word, this paper has discussed the general rules of selecting ROI and the specific rules of selecting ROI in e-commerce applications. The simulation results are given, and the satisfactory results have been achieved.