Hybrid Patterns Recognition of Control Chart Based on WA-PCA-PSO-SVM

Liu Yan-zhong,Zhang Hong-lie,Liu Yan-ju,Jiang Jin-gang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10

Based on the analysis of the defect of traditional model, this paper proposes a new control chart pattern recognition model, which includes Wavelet Analysis (WA), Principal Component Analysis (PCA), Particle Swarm Optimization (PSO) and Support Vector Machine (SVM). WA is good to eliminate noise control chart anomaly pattern recognition of the adverse effect. PCA eliminates the redundant information of data between SVM and reduces the input dimension and computational complexity. PSO algorithm optimizes the parameters of SVM and the establishment of the optimal control chart anomaly pattern classifier can solve the problem optimal parameters of SVM. The simulation results show that the model is feasible, the results are reliable. This algorithm improves the control chart abnormal state average recognition accuracy and be used in the machining process real-time monitoring.

FRACTAL ANALYSIS FOR FRACTURE PROCESS OF ROLYMER MATERIALS

Liu, Liu, Xiaobo,Gu, Gu, Yi,Jiang, Jiang, Luxia,Cai, Cai, Xingxian 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.3

This work focuses on fractal analysis for fracture process of polymer materials in theoric model and experimental ditermination. A series of theoric fractal model based on fracutred surface for fracutre process of polymer materials are founded, and the fractal dimension of fractured surface wa obtained under various break mechanism including crack in shear bands, crack development in stonely wave, crack cross, break in brittle, fractured pocess for the rigid filtered polymers and self-reinforced liquid crystal thermotes. These results retlected that the bigger the fractal dimensiion of the fractured surface, the higher the toughenss of polymer materials. According to Griffith strength, the mechanical properties of polymers increased lindarly with the rise of fractal dimension value.

Senescence as A Consequence of Ginsenoside Rg₁ Response on K562 Human Leukemia Cell Line

Liu, Jun,Cai, Shi-Zhong,Zhou, Yue,Zhang, Xian-Ping,Liu, Dian-Feng,Jiang, Rong,Wang, Ya-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Aims and Background: Traditional chemotherapy strategies for human leukemia commonly use drugs based on cytotoxicity to eradicate cancer cells. One predicament is that substantial damage to normal tissues is likely to occur in the course of standard treatments. Obviously, it is urgent to explore therapies that can effectively eliminate malignant cells without affecting normal cells. Our previous studies indicated that ginsenoside $Rg_1$ ($Rg_1$), a major active pharmacological ingredient of ginseng, could delay normal hematopoietic stem cell senescence. However, whether $Rg_1$ can induce cancer cell senescence is still unclear. Methods: In the current study, human leukemia K562 cells were subjected to $Rg_1$ exposure. The optimal drug concentration and duration with K562 cells was obtained by MTT colorimetric test. Effects of $Rg_1$ on cell cycle were analyzed using flow cytometry and by SA-${\beta}$-Gal staining. Colony-forming ability was measured by colony-assay. Telomere lengths were assessed by Southern blotting and expression of senescence-associated proteins P21, P16 and RB by Western blotting. Ultrastructural morphology changes were observed by transmission electron microscopy. Results: K562 cells demonstrated a maximum proliferation inhibition rate with an $Rg_1$ concentration of $20{\mu}\;mol{\cdot}L^{-1}$ for 48h, the cells exhibiting dramatic morphological alterations including an enlarged and flat cellular morphology, larger mitochondria and increased number of lysosomes. Senescence associated-${\beta}$-galactosidase (SA-${\beta}$-Gal) activity was increased. K562 cells also had decreased ability for colony formation, and shortened telomere length as well as reduction of proliferating potential and arrestin $G_2$/M phase after $Rg_1$ interaction. The senescence associated proteins P21, P16 and RB were significantly up-regulated. Conclusion: Ginsenoside $Rg_1$ can induce a state of senescence in human leukemia K562 cells, which is associated with p21-Rb and p16-Rb pathways.

Esomeprazole magnesium enteric-coated pellet-based tablets with high acid tolerance and good compressibility

Jiang‑Yan Liu,Xiao‑Xue Zhang,Hao‑Yan Huang,이범진,Jing‑Hao Cui,Qing‑Ri Cao 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3

The aim of this study was to develop esomeprazole magnesium (EMZ-Mg) enteric-coated pellets and pellet-based tablets, as well as to investigate the effects of pellet size and compression method on acid tolerance, content uniformity, compressibility, and stability of preparations. This study used two types of pellet cores, namely, microcrystalline cellulose (MCC) core with a particle size of 150–300 μm and sucrose core with a particle size of 600–700 μm. Enteric-coated pellets, which consisted of a drug-free core, a drug layer, a sub-coating layer (hydroxypropyl methylcellulose, 6 cps), and an enteric-coating layer ( Eudragit®L30D-55), were prepared by using a bottomspray fluidized bed-coating technique. Pellet-based tablets were prepared by using a direct compression method or a wet granulation method. The acid tolerances of the two types of enteric-coated pellets (MCC and sucrose cores) reached up to 98% in simulated gastric fluid (pH 1.0) within 2 h, and the dissolution rates in simulated intestinal fluid (pH 6.8) reached up to 85% of the labeled amount within 15 min. When compressed into tablets, the pellets based on MCC core (smaller particle size) displayed a significantly higher acid tolerance (up to 92%) compared with the pellets based on sucrose core (larger particle size). In addition, the MCC core-based tablets (F8), especially those prepared by using a granulation method, showed higher drug content uniformity and compressibility than the sucrose core-based tablets (F10), and no lamination phenomenon was observed during compression. The crystallinity of EMZ-Mg was altered during drug layering process, and some physicochemical interactions were observed between the drug and excipients. Moreover, the two types of enteric-coated pellets showed a relatively high stability after storage under high temperature and strong light. However, they showed poor stability under high humidity, resulting in remarkable degradation of active compound. The EMZ-Mg entericcoated pellets and pellet-based tablets were successfully developed, and reduction in pellet size and wet granulation reduced the differences in content uniformity and better protected the pellet coating from damages during compression.

Plasmonic Nanoantennae Fabricated by Focused Ion Beam Milling

Jiang-Tao Lv,Yuan Yan,Wei-Kang Zhang,Yun-Hui Liu,Zi-Yu Jiang,Guang-Yuan Si 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

We show a novel approach to fabricate plasmonic nanoantennae based on a maskless focused ion beam nanoring patterning process. Antenna nanoarrays with desired outlines are achieved by precisely controlling the geometric parameters during the milling process. Various nanoantenna designs of bow-tie, nanoclusters (pentamers), and ellipsoid shaped satellites surrounded particle lattices arerealized. The whole fabrication method is programmable and monolithic since only a one-step milling process is involved. The opticalproperties are experimentally characterized. Such nanoantennae may find extensive applications in chemical/bio-sensing due toremarkably enhanced near field intensity at the plasmon resonance.

Systematic influence of different building spacing, height and layout on mean wind and turbulent characteristics within and over urban building arrays

Jiang, Dehai,Jiang, Weimei,Liu, Hongnian,Sun, Jianning Techno-Press 2008 Wind and Structures, An International Journal (WAS Vol.11 No.4

Large eddy simulations have been performed within and over different types of urban building arrays. This paper adopted three dimensionless parameters, building frontal area density (${\lambda}_f$) the variation degree of building height (${\sigma}_h$), and the staggered degree of building range ($r_s$), to study the systematic influence of building spacing, height and layout on wind and turbulent characteristics. The following results have been achieved: (1) As ${\lambda}_f$ decrease from 0.25 to 0.18, the mean flow patterns transfer from "skimming" flow to "wake interference" flow, and as ${\lambda}_f$ decrease from 0.06 to 0.04, the mean flow patterns transfer from "wake interference" flow to "isolated roughness" flow. With increasing ${\lambda}_f$, wind velocity within arrays increases, and the vortexes in front of low buildings would break, even disappear, whereas the vortexes in front of tall buildings would strengthen and expand. Tall buildings have greater disturbance on wind than low buildings do. (2) All the wind velocity profiles and the upstream profile converge at the height of 2.5H approximately. The decay of wind velocity within the building canopy was in positive correlation with ${\lambda}_f$ and $r_s$. If the height of building arrays is variable, Macdonald's wind velocity model should be modified through introducing ${\sigma}_h$, because wind velocity decreases at the upper layers of the canopy and increases at the lower layers of the canopy. (3) The maximum of turbulence kinetic energy (TKE) always locates at 1.2 times as high as the buildings. TKE within the canopy decreases with increasing ${\lambda}_f$ and $r_s$ but the maximum of TKE are very close though ${\sigma}_h$ varies. (4) Wind velocity profile follows the logarithmic law approximately above the building canopy. The Zero-plane displacement $z_d$ heighten with increasing ${\lambda}_f$, whereas the maximum of and Roughness length $z_0$ occurs when ${\lambda}_f$ is about 0.14. $z_d$ and $z_0$ heighten linearly with ${\sigma}_h$ and $r_s$, If ${\sigma}_h$ is large enough, $z_d$ may become higher than the average height of buildings.

Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer

Jiang Liu,Rong Xu,Xiaolei He,Reyina Wufuli,Ying Su,Lili Ma,Ru Chen,Zhongcheng Han,Fang Wang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.4

Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. Materials and Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed. Results: There were no significant differences in the objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control rate (72.73% vs. 73.81%, P>0.05), progression-free survival (hazard ratio [HR], 1.119; 95% confidence interval [CI], 0.739–1.741; P=0.586), and overall survival (OS; HR, 0.855; 95% CI, 0.481–1.511; P=0.588) between CAPOX and SOX. A higher number of stage IV patients showed TP positivity, while DPD-positive patients predominantly showed intestinal type of gastric cancer. In TP-positive patients, the ORRs associated with CAPOX and SOX treatments were 57.14% and 38.10%, respectively; OS was better with CAPOX than with SOX (HR, 0.447; 95% CI, 0.179–0.978; P=0.046). Among DPD-positive patients, the SOX treatment-associated ORR (60.87%) was significantly higher than the CAPOX treatment-associated ORR (43.48%). Furthermore, SOX treatment resulted in better OS than did CAPOX treatment (HR, 2.020; 95% CI, 1.019–4.837; P=0.049). Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer.

A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb

Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.

Phase Only Pupil Filter Design Using Zernike Polynomials

Jiang Liu,Erlong Miao,Yongxin Sui,Huaijiang Yang 한국광학회 2016 Current Optics and Photonics Vol.20 No.1

A pupil filter is a useful technique for modifying the light intensity distribution near the focus of anoptical system to realize depth of field (DOF) extension and superresolution. In this paper, we proposeda new design of the phase only pupil filter by using Zernike polynomials. The effect of design parametersof the new filters on DOF extension and superresolution are discussed, such as defocus Strehl ratio (S.R.),superresolution factor (G) and relative first side lobe intensity (M). In comparison with the other two typesof pupil filters, the proposed filter presents its advantages on controlling both the axial and radial lightintensity distribution. Finally, defocused imaging simulations are carried out to further demonstrate theeffectiveness and superiority of the proposed pupil filter on DOF extension and superresolution in an opticalimaging system.

A Novel Self-Organized Fuzzy Neural Network Surface Reconstruction Algorithm for Point Clouds Without Normal

Liu Yan-ju,Liu Yan-zhong,Tao Bai-rui,Jiang Jin-gang,Zhang Hong-lie 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.4