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      • KCI등재

        Understanding the attitudes toward sunless tanning product use: implication of tanning product consumption

        JeongJu Yoo,Hyeon Jeong Cho 한국의류학회 2018 Fashion and Textiles Vol.5 No.1

        The goal of this study is to test the antecedents of overall attitudes toward sunless tanning product use. The data collected from 302 US female college students with an average age of 20.11 were included in the analysis. A structural equation modeling was performed to test the hypothesized relationships. The results revealed that body surveillance and social ostracism influenced the individuals’ cutaneous body image dissatisfaction, which also influenced perceived attractiveness and fitness of tanned appearance. Perceived tanning attractiveness and perceived tanning physical fitness positively influences attitudes toward tanning product use. It is evident that seeing one’s own body through the lens of others is at the root of positive attitudes toward sunless tanning products. Positive attitudinal changes toward sunless tanning products can be successfully established emphasizing sunless tanning products as fashion consumption. The findings in this study have important relevance, in that tanning products can be marketed as cosmetic appearance-enhancement products for people to look attractive, toned, and fit.

      • 신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석

        송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

        In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).

      • 국내 상급종합병원과 종합병원 간호사의 정맥주입간호실무지침의 확산정도

        은영(Young Eun),구미옥(Mee Ok Gu),조용애(Young Ae Cho),정재심(Jae Shim Jeong),권정순(Jeong Soon Kwon),유정숙(Cheong Suk Yoo5),정영선(Young Sun Jeong),정인숙(In Sook Jung),김경숙(Kyeong Sug Kim),이선희(Seon Heui Lee),서현주(Hyun Ju S 한국근거기반간호학회 2015 근거와 간호 Vol.3 No.1

        Purpose: This study was conducted to investigate the extent of diffusion of Intravenous infusion nursing practice guideline among nurses in advanced general hospitals and general hospitals in Korea. Methods: The subjects were 234 nurses who practice the intravenous infusion in 24 advanced general hospitals and general hospitals. Data were collected between October 5 and November 2, 2015 by mail (return rates: 97.5 %). Data were analyzed using descriptive statistics, t-test, and ANOVA with SPSS/ WIN 21. Results: The average guideline diffusion score and levels of diffusion was 3.39±0.58 (level of “use sometimes”). 44 recommendations (46%) were in level of “use always” and 50 recommendations (53%) were in “use sometimes”. Extent of diffusion were significantly different according to present status (F=2.81, p=.040) and education (F=4.35, p=.014). The facilitating factors to use the guideline were education by department of nursing service, convenient composition of guideline and barrier factors were “no time to use the guideline”, “don’t know the guideline” and “there is no guideline at ward”. Conclusion: Extent of diffusion of Intravenous infusion nursing practice guideline among nurses was moderate level. The strategies for promoting the implementation of guideline in clinical practice is needed. Further study of outcome evaluation of guideline implementation will be needed.

      • Optimal Selection of Sedative Drug during Gastroduodenoscopy in Cirrhotic Patients to Avoid Minimal Encephalopathy: Interim-Analysis of Randomized Controlled Trial

        ( Jeong-ju Yoo ),( Hyeon Jeong Goong ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: The indiscriminate use of sedative drug during endoscopy can pose a risk of minimal hepatic encephalopathy (MHE) in patient with liver cirrhosis, . However, it has not been studied yet which drugs are safest and most inviting on these patients. The aim of this study is to evaluate which one among midazolam, propofol, or combination therapy, was the least likely to cause complications including MHE by using Stroop application in cirrhotic patients. Methods: This randomized prospective study included consecutive 32 patients who underwent upper GI endoscopy at tertiary hospitals in Korea. Patients were randomly assigned to one of three groups, midazolam, propofol, or combination group, and underwent Stroop test before endoscopy, and 2 hours after the completion of endoscopy. The vital signs was checked before and after the drug administration and the patient / physician / nurse satisfaction was scored after endoscopy. Results: Mean age of the patients was 54.0 ± 9.30 years and 81.3% were male. Fifteen patients (46.9%) were child-pugh class A, and 17 (53.1%) were child-pugh class B or C. Alcohol was the most common etiology (21, 65.6%). Patients did not show significant changes in Ontime, Offtime on Stroop test before and after drug administration, and there was no significant difference between the three treatment groups. Also, there was no significant vital sign changes after drug use in all groups. However, with respect to subjective indicators, the satisfaction scores of patient and nursing staff was higher in the combined group than in the other two groups, and time to recovery was shorter in propofol than other groups. Conclusions: In patients with cirrhosis, sedative endoscopy using midazolam, propofol, or combination therapy is relatively safe, and was not associated with increased risk of MHE. However, since there is subjective satisfaction or recovery time difference among sedative agents, it should be considered according to each individual patient.

      • SCOPUSKCI등재

        Applicability and Safety of in Vitro Skin Expansion Using a Skin Bioreactor: A Clinical Trial

        Jeong, Cheol,Chung, Ho Yun,Lim, Hyun Ju,Lee, Jeong Woo,Choi, Kang Young,Yang, Jung Dug,Cho, Byung Chae,Lim, Jeong Ok,Yoo, James J.,Lee, Sang Jin,Atala, Anthony J. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6

        Background Tissue expansion is an effective and valuable technique for the reconstruction of large skin lesions and scars. This study aimed to evaluate the applicability and safety of a newly designed skin expanding bioreactor system for maximizing the graft area and minimizing the donor site area. Methods A computer-controlled biaxial skin bioreactor system was used to expand skin in two directions while the culture media was changed daily. The aim was to achieve an expansion speed that enabled the skin to reach twice its original area in two weeks or less. Skin expansion and subsequent grafting were performed for 10 patients, and each patient was followed for 6 months postoperatively for clinical evaluation. Scar evaluation was performed through visual assessment and by using photos. Results The average skin expansion rate was $10.54%{\pm}6.25%$; take rate, $88.89%{\pm}11.39%$; and contraction rate, $4.2%{\pm}2.28%$ after 6 months. Evaluation of the donor and recipient sites by medical specialists resulted in an average score of 3.5 (out of a potential maximum of 5) at 3 months, and 3.9 at 6 months. The average score for patient satisfaction of the donor site was 6.2 (out of a potential maximum of 10), and an average score of 5.2 was noted for the recipient site. Histological examination performed before and after the skin expansion revealed an increase in porosity of the dermal layer. Conclusions This study confirmed the safety and applicability of the in vitro skin bioreactor, and further studies are needed to develop methods for increasing the skin expansion rate.

      • Relationship between Timing of Endoscopy and Mortality in Cirrhotic Patient with Variceal Bleeding

        ( Jeong-ju Yoo ),( Young Chang ),( Eun Ju Cho ),( Sang Gyune Kim ),( Young Seok Kim ),( Yun Bin Lee ),( Jeong-hoon Lee ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: The optimal timing of emergency endoscopy in patients with variceal bleeding is remains unclear. Most guidelines recommend performing endoscopic evaluation and treatment within 12 hours after patient’s arrival, but there are few related studies. The aim of this study was to examine the association between timing of endoscopy and mortality of esophageal variceal bleeding in cirrhotic patients. Methods: This retrospective study included 274 of consecutive patients admitted to two tertiary hospitals in Korea due to esophageal variceal bleeding. Using descriptive statistics and Kaplan-Meier survival analyses, we analyzed the association between the timing of endoscopy and patients’ mortality. We adjusted confounding factors and balanced the baseline characteristics of the subjected patients using Cox proportional hazards model and inverse probability weighting (IPW) method. Results: A total of 173 patients received endoscopy within 12 hours after admission and 101 patients, after 12 hours. Endoscopy was performed after a median of 7.6 hours (interquartile range [IQR], 2.9-16.5) after admission. The median overall survival (OS) was 8.2 months (IQR, 1.4-25.9) months, and in-hospital mortality was 8.0%. Performing endoscopy within 12 hours was associated with longer OS than performing after 12 hours (33.2 vs. 23.5 months, log-rank P=0.01). Early endoscopy was independently associated with longer OS after adjusting presence of hepatocellular carcinoma, MELD score, and Glasgow-Blatchford score (adjusted hazard ratio [aHR] 1.61, 95% confidence interval [CI]=1.05-2.46, P=0.03). Also, after balancing baseline characteristics using IPW, endoscopy within 12 hours group consistently showed longer OS than endoscopy after 12 hours group (aHR 2.17, 95% CI=1.56-3.03; P=0.03). However, outcomes were not significantly different between the urgent (within 6 hours) and early endoscopy groups. Conclusions: Timing of endoscopy is associated with mortality in patients with esophageal variceal bleeding. It is important to perform emergency endoscopy within 12 hours, especially for high-risk patients.

      • Blocking Energy Metabolism by Hexokinase II Inhibitor Overcomes Sorafenib Resistance via Augmenting Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

        ( Jeong-ju Yoo ),( Su Jong Yu ),( Juri Na ),( Kyungmin Kim ),( Young Youn Cho ),( Hyeki Cho ),( Dong Hyeon Lee ),( Eun Ju Cho ),( Jeong-hoon Lee ),( Yoon Jun Kim ),( Chung Yong Kim ),( Hyewon Youn ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

        Aims: Enhancing sorafenib sensitivity is essential for achieving efficient control of intractable hepatocellular carcinoma (HCC). Considering that sorafenib exerts its effect by endoplasmic reticulum (ER) stress due to hypoxia and energy depletion through anti-angiogenic aspect, hexokinase (HK) II which is an important rate-limiting glycolytic enzyme can be a key player in countervailing the effect of sorafenib. Pyruvate analog 3-bromopyruvate (3-BP), a HK II inhibitor, can promote tumor cell death by augmenting endoplasmic reticulum (ER) stress in human HCC cell lines. We evaluated inhibition of HK II potentiated sorafenib-induced ER stress in HCC cells. We also postulated that simultaneous treatment with sorafenib and 3-BP might synergistically enhance their anti-tumor efficacies against HCCs in vivo models. Methods: HCC apoptotic cell death was assessed by DAPI staining and apoptotic signaling pathways were explored by immunoblot analysis. Energy depletion was assessed by lactate assay. In vivo ectopic model of HCC was established in BALB-c nu/nu mice intradermally implanted with SNU-761 cells. Moreover, orthotopic model of HCC was established by subcapsular injection of SNU-761 cells via mini-laparotomy in BALB-c nu/nu mice. Sorafenib with/without 3-BP was subsequently administered. The anti-tumor efficacies were

      • KCI등재

        Long-term prognosis and the need for histologic assessment of chronic hepatitis B in the serological immune-tolerant phase

        Jeong-Ju Yoo,Soo Young Park,Ji Eun Moon,Yu Rim Lee,Han Ah Lee,Jieun Lee,Young Seok Kim,Yeon Seok Seo,Sang Gyune Kim 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.2

        Background/Aims: The histologic status of the immune-tolerant (IT) phase of chronic hepatitis B relative to long-term outcomes is unclear. This study aimed to discover how the serological criteria currently in use correspond to histologic criteria in determining the IT phase and indication for liver biopsy. Methods: Patients in the serological IT phase determined by positive hepatitis B e antigen, hepatitis B virus (HBV) DNA ≥106 IU/mL, and normal or minimally elevated alanine aminotransferase (ALT) ≤60 IU/L, who underwent liver biopsy at three different hospitals were included. The distribution of the histologic IT phase, defined as fibrosis of stage 1 or less and inflammation of grade 1 or less, was compared with that of the serological IT phase. The risk factors for the incidence of liver-related events, such as hepatocellular carcinoma, liver cirrhosis, liver transplantation, and death, were also analyzed. Results: Eighty-two (31.7%) out of 259 clinically suspected IT phase patients belonged to the histologic IT phase. Age over 35, high AST, and low albumin were useful for ruling out the histologic IT phase. Risk factors predicting liver-related events were age and significant fibrosis stage. There was no significant difference in the proportion of histologic IT phase and clinical prognosis between normal ALT and mildly elevated ALT groups. However, even in patients with normal ALT, age was an important factor in predicting the presence of the histologic IT phase. Conclusions: A significant number of patients who belonged to the serological IT phase were not in the histologic IT phase. Patients over 35 years and those with high AST, low albumin, and low HBV DNA levels were more likely to experience poor long-term clinical outcomes. Therefore, additional histologic assessment should be considered.

      • Clinical Significance of Relative Adrenal Insufficiency on the Development of Complications and Mortality in Patients with Liver Cirrhosis

        ( Jeong-ju Yoo ),( Sang Gyune Kim ),( Seong Joon Chun ),( Young Seok Kim ),( Young Chang ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

        Aims: It is not yet known how much relative adrenal insufficiency (RAI) affects the prognosis of patients with liver cirrhosis. We evaluated the prevalence of RAI in hospitalized patients with liver cirrhosis, and examined their association with prognosis. Methods: This study included 297 consecutive cirrhosis patients who underwent rapid ACTH stimulation test. RAI was defined by a delta cortisol lower than 9 g/dL and/or a peak cortisol lower than 18 g/dL. Results: RAI was diagnosed in 183 patients (61.6%) of the 297 patients. The group in RAI (+) had older age, a higher rate with infection, and a deteriorated liver function than the group in RAI (-). In addition, the cause of death from infection was higher in RAI (+) group than RAI (-) group (26.8% vs. 11.8%). The presence of RAI increased significantly the risk of hepatic encephalopathy, acute kidney injury and 3-month mortality. The clinical effect of RAI was further enhanced in the subgroup with relatively higher muscle mass (> ~~)and lower white blood cell count group (< 10,000 μL). Conclusions: The presence of RAI is relatively frequent in cirrhotic patients with older age, poor liver function and infection In addition, RAI significantly affects the development of complications and the prognosis of liver cirrhosis.

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