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Jeena, M. T.,Lee, Jung-In,Kim, Si Hoon,Kim, Chanhoon,Kim, Ju-Young,Park, Soojin,Ryu, Ja-Hyoung American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.20
<P>This work demonstrates the design, synthesis, characterization, and study of the electrochemical performance of a novel binder for silicon (Si) anodes in lithium-ion batteries (LIBs). Polymeric binders with three different functional groups, namely, carboxylic acid (COOH), carboxylate (COO<SUP>–</SUP>), and hydroxyl (OH), in a single polymer backbone have been synthesized and characterized via <SUP>1</SUP>H NMR and FTIR spectroscopies. A systematic study that involved varying the ratio of the functional groups indicated that a material with an acid-to-alcohol molar ratio of 60:40 showed promise as an efficient binder with an initial columbic efficiency of 89%. This exceptional performance is attributed to the strong adhesion of the binder to the silicon surface and to cross-linking between carboxyl and hydroxyl functional groups, which minimize the disintegration of the Si anode structure during the large volume expansion of the lithiated Si nanoparticle. Polymers with multiple functional groups can serve as practical alternative binders for the Si anodes of LIBs, resulting in higher capacities with less capacity fade.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-20/am504854x/production/images/medium/am-2014-04854x_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am504854x'>ACS Electronic Supporting Info</A></P>
Wnt activation is implicated in glioblastoma radioresistance.
Kim, Yonghyun,Kim, Kang Ho,Lee, Jeena,Lee, Young-Ae,Kim, Misuk,Lee, Se Jeong,Park, Kernyu,Yang, Heekyoung,Jin, Juyoun,Joo, Kyeung Min,Lee, Jeongwu,Nam, Do-Hyun United States and Canadian Academy of Pathology [e 2012 Laboratory investigation Vol.92 No.3
<P>Glioblastoma (GBM) patients have dismal median survival even with the most rigorous treatments currently available. Radiotherapy is the most effective non-surgical therapy for GBM patients; however, patients succumb due to tumor recurrence within a year. To develop a curative therapeutic approach, we need to better understand the underlying molecular mechanism of radiation resistance in GBM. Towards this goal, we developed an in vivo orthotopic GBM model system that mimics the radiation response of human GBM, using both established-GBM cell line and patient-derived freshly dissociated GBM specimen. In-vivo ionizing radiation (IR) treatment prolonged the survival of mice with intracranical tumor derived from U373MG, but failed to prevent tumor recurrence. U373MG and GBM578 cells isolated after in-vivo IR (U373-IR and 578-IR) were more clonogenic and enriched with stem cell-like characteristics, compared with mock-treated control tumor cells. Transcriptomic analyses and quantitative real-time reverse-transcription PCR analyses using these matched GBM cells before and after radiation treatment revealed that Wnt pathways were preferentially activated in post-IR GBM cells. U373-IR cells and 578-IR were enriched with cells positive for both active β-catenin (ABC) and Sox2 population, and this subpopulation was further increased after additional in-vitro radiation treatment, suggesting that radiation resistance of GBM is mediated due, in part, to the activation of stem cell-associated pathways including Wnt. Finally, pharmacological and siRNA inhibition of Wnt pathway significantly decreased the survival and clonogenicity of GBM cells and reduced their ABC(+)/Sox2(+) population. Together, these data suggest that Wnt activation is a molecular mechanism to confer GBM radioresistance and an important therapeutic target.</P>
Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells
Kim, Sangpil,Palanikumar, L.,Choi, Huyeon,Jeena, M. T.,Kim, Chaekyu,Ryu, Ja-Hyoung Royal Society of Chemistry 2018 Chemical Science Vol.9 No.9
<▼1><P>Mitochondria targeting mineralization can form biominerals inside cancerous mitochondria through concentration dependent silicification, resulting in dysfunction of mitochondria leading to apoptosis. These results suggest potential therapeutics for cancer treatment.</P></▼1><▼2><P>The use of biomineralization that regulates cellular functions has emerged as a potential therapeutic tool. However, the lack of selectivity still limits its therapeutic efficacy. Here, we report a subcellular-targeting biomineralization system featuring a triphenylphosphonium cation (TPP) (the mitochondria-targeting moiety) and trialkoxysilane (the biomineralization moiety <I>via</I> silicification). The TPP-containing trialkoxysilane exhibited approximately seven times greater cellular uptake into cancer cells (SCC7) than into normal cells (HEK293T) due to the more negative mitochondrial membrane potentials of the cancer cells. In turn, its accumulation inside mitochondria (pH 8) induces specific silicification, leading to the formation of silica particles in the mitochondrial matrix and further activation of apoptosis. <I>In vivo</I> assessment confirmed that the biomineralization system efficiently inhibits tumor growth in a mouse xenograft cancer model. Exploiting both the subcellular specificity and the targeting strategy provides new insight into the use of intracellular biomineralization for targeted cancer therapy.</P></▼2>
Jeena, M. T.,Bok, Taesoo,Kim, Si Hoon,Park, Sooham,Kim, Ju-Young,Park, Soojin,Ryu, Ja-Hyoung Royal Society of Chemistry 2016 Nanoscale Vol.8 No.17
<P>The electrochemical performance of Li-ion batteries (LIBs) can be highly tuned by various factors including the morphology of the anode material, the nature of the electrolyte, the binding material, and the percentage of conducting materials. Binding materials have been of particular interest to researchers over the decades as a means to further improve the cycle durability and columbic efficiency of LIBs. Such approaches include the introduction of different polymeric binders such as poly(acrylic acid) (PAA), carboxymethyl cellulose (CMC), and alginic acid (Alg) into the Si anode of LIBs. To achieve a better efficiency of LIBs, herein, we introduce a novel copolymer, poly(tert-butyl acrylate-co-triethoxyvinylsilane) (TBA-TEVS), as an efficient binder with stable cycle retention and excellent specific capacity. The binder forms a highly interconnected three-dimensional network upon thermal treatment as a result of de-protection of the tert-butyl group and the consequent inter-intra condensation reaction, which minimizes pulverization of the Si nanoparticles. Moreover, the siloxane group is expected to promote the formation of stable solid-electrolyte-interface (SEI) layers. A series of random copolymers were synthesized by varying the molar ratio of tert-butyl acrylate and triethoxyvinylsilane. Twenty-one percent of TEVS in the TBS-TEVS copolymer gave rise to a superior performance as a binder for Si anodes, where the anodes showed a stable specific capacity of 2551 mA h g(-1) over hundreds of cycles and an initial columbic efficiency (ICE) of 81.8%.</P>
황지나(Jeena Hwang),서주환(Ju Hwan Seo),임정선(Jung-Sun Lim),유형선(Hyoung Sun Yoo),박진한(Jinhan Park),김유일(You-eil Kim),김지희(Ji Hui Kim) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.7
기업 내부 및 외부 환경 요인 분석을 통한 올바른 비즈니스 전략 수립은 기업의 혁신성과 창출로 이어질 수 있다. 때문에 SWOT 분석을 통해 기업 내부의 강점요인과 약점요인을 인지하고, 기업 외부의 기회요인과 위협요인을 정확하게 분석하는 과정은 매우 중요하다. 그러나 많은 기업들이 그들의 상대적인 강점요인과 약점요인, 기회요인과 위협요인에 대해 정확하게 판단하지 못하는 경우가 많다. 본 연구는 기업이 환경분석 과정에서 보편적으로 활용하는 분석모델 중 하나인 SWOT 분석을 지원하는 도구를 설계 및 구현한 것으로, 각 분야의 전문가들이 작성한 SWOT 분석 결과를 바탕으로 SWOT 분석 사례 DB를 만들어 사용자가 데이터베이스에 저장되어있는 각각의 환경요소를 조회하여 기업에 적합한 환경요소들을 선택, 수정, 추가하게 함으로써 SWOT 분석 시에 기업들이 고려해야하는 내부 및 외부 환경 요인에 대한 정보를 제공하고자 한다. 이를 통해 기업들이 자신의 내부 역량에 대해 보다 정확하게 인지하고, 외부 환경 변화에 대한 고찰을 도울 수 있을 것으로 사료된다. The best business strategy leading to innovation and productivity can be achieved by carefully analyzing internal and external environments of a company. Many companies often require, but difficult to find a tool to determine their own internal/external environmental factors including strengths, weaknesses, opportunities and threats(SWOT). SWOT is one analytical base model that is utilized in this research to design semi-automated environmental analysis process. This study investigates on SWOT generation system that is built on existing analysis database created by experts in each field. Companies can search and choose their best expressing environmental elements that are stored in the database. This semi-automated SWOT tool is expected to contribute that companies can recognize their internal capabilities more accurately, and help consider external environment changes around them.