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Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex
Qian, T,Lee, J-Y,Park, J-H,Kim, H-J,Kong, G Macmillan Publishers Limited 2010 Oncogene Vol.29 No.43
The helix–loop–helix inhibitor of differentiation and DNA binding (Id1) is well known as an oncogene in various tumors. Although it has been reported that Id1 promotes several oncogenic processes, it is still unclear whether Id1 functions through epigenetic transcriptional regulation. In this study, we examined the effect of Id1 on polycomb group (PcG) proteins, which are crucial epigenetic gene silencers, and found that Id1 regulated the expression of Mel-18 and Bmi-1, both of which belong to polycomb repressive complex 1. We also confirmed that Id1 induced Mel-18 downregulation, which was mediated by the Akt pathway, and consequently upregulated the transcription of its target gene, c-Myc. Using a promoter–reporter, we demonstrated that Id1 regulated Bmi-1 transcription through c-Myc binding to its E-box in the promoter. Finally, we examined the activity of E3 ligase RING1b, whose catalytic activity is increased by binding with the RING finger protein Bmi-1, and found that Id1 overexpression enhanced RING1b E3 ligase activity leading to accumulation of H2A ubiquitination and ubiquitin/proteasome-mediated degradation of geminin. Taken together, our study provided a novel link between Id1 and PcG proteins and suggested that Id1 may contribute to tumor development through PcG-mediated epigenetic regulation.
The extraction of φ–N total cross section from d(γ,p<sup>K+</sup><sup>K−</sup>)n
Qian, X.,Chen, W.,Gao, H.,Hicks, K.,Kramer, K.,Laget, J.M.,Mibe, T.,Stepanyan, S.,Tedeschi, D.J.,Xu, W.,Adhikari, K.P.,Amaryan, M.,Anghinolfi, M.,Baghdasaryan, H.,Ball, J.,Battaglieri, M.,Batourine, V Elsevier 2009 Physics letters: B Vol.680 No.5
<P><B>Abstract</B></P><P>We report on the first measurement of the differential cross section of <I>φ</I>-meson photoproduction for the d(γ,p<SUP>K+</SUP><SUP>K−</SUP>)n exclusive reaction channel. The experiment was performed using a tagged-photon beam and the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. A combined analysis using data from the d(γ,p<SUP>K+</SUP><SUP>K−</SUP>)n channel and those from a previous publication on coherent <I>φ</I> production on the deuteron has been carried out to extract the φ−N total cross section, <SUB>σφN</SUB>. The extracted φ−N total cross section favors a value above 20 mb. This value is larger than the value extracted using vector-meson dominance models for <I>φ</I> photoproduction on the proton.</P>
Qian, A.,Zhuo, K.,Choi, B.N.,Lee, S.J.,Bae, J.W.,Yoo, P.J.,Chung, C.H. Elsevier Sequoia 2016 JOURNAL OF ALLOYS AND COMPOUNDS Vol.688 No.2
The oriented synthesis of high-performance nanobelt/graphene hybrids remains a challenge by one-step environmentally friendly process for supercapacitors. Here, PEG-6000 manipulation was employed to facilitate ultra-long V<SUB>2</SUB>O<SUB>5</SUB>.0.5H<SUB>2</SUB>O nanobelts on surface of reduced graphene oxide (rGO). As a result, due to faster and efficient electron transfer and collection, V<SUB>2</SUB>O<SUB>5</SUB>.0.5H<SUB>2</SUB>O/rGO hybrid (rGO: 5 wt%-50 wt%) significantly enhances electrochemical capacitance for supercapacitors. Especially, introduction of 50 wt% rGO in the hybrid (denoted as 50 wt% rGO-V) exhibits a high capacitance of 649 F g<SUP>-1</SUP> at a scan rate of 5 mV s<SUP>-1</SUP> in a neutral KCl electrolyte. On the other hand, the hybrid material shows a high-rate capacitance of 160 F g<SUP>-1</SUP> at a current density of 1 A g<SUP>-1</SUP>. Additionally, capacitance retention of 93% was obtained after 600 cycles, implying excellent cycling stability in the 50 wt% rGO-V hybrid. This study is beneficial to understand synergetic effects in V<SUB>2</SUB>O<SUB>5</SUB>.0.5H<SUB>2</SUB>O/rGO hybrid materials and even useful for oriented synthesis of hybrid materials in other energy storage devices.
Katich, J.,Qian, X.,Zhao, Y. X.,Allada, K.,Aniol, K.,Annand, J. R. M.,Averett, T.,Benmokhtar, F.,Bertozzi, W.,Bradshaw, P. C.,Bosted, P.,Camsonne, A.,Canan, M.,Cates, G. D.,Chen, C.,Chen, J.-P.,Chen, American Physical Society 2014 Physical Review Letters Vol.113 No.2
<P>We report the first measurement of the target-normal single-spin asymmetry in deep-inelastic scattering from the inclusive reaction 3)He()(e,e')X on a polarized (3)He gas target. Assuming time-reversal invariance, this asymmetry is strictly zero in the Born approximation but can be nonzero if two-photon-exchange contributions are included. The experiment, conducted at Jefferson Lab using a 5.89 GeV electron beam, covers a range of 1.7<W<2.9??GeV, 1.0<Q(2)<4.0??GeV(2) and 0.16<x<0.65. Neutron asymmetries were extracted using the effective nucleon polarization and measured proton-to-(3)He cross-section ratios. The measured neutron asymmetries are negative with an average value of (-1.090.38)10(-2) for invariant mass W>2??GeV, which is nonzero at the 2.89σ level. Our measured asymmetry agrees both in sign and magnitude with a two-photon-exchange model prediction that uses input from the Sivers transverse momentum distribution obtained from semi-inclusive deep-inelastic scattering.</P>
A numerical and theoretical investigation on composite pipe-in-pipe structure under impact
Xudong Qian,Yu Wang,J.Y. Richard Liew,Min-Hong Zhang 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.5
This paper investigates the transverse impact response for ultra lightweight cement composite (ULCC) filled pipe-in-pipe structures through a parametric study using both a validated finite element procedure and a validated theoretical model. The parametric study explores the effect of the impact loading conditions (including the impact velocity and the indenter shape), the geometric properties (including the pipe length and the dimensions of the three material layers) as well as the material properties (including the material properties of the steel pipes and the filler materials) on the impact response of the pipe-in-pipe composite structures. The global impact responses predicted by the FE procedure and by the theoretical model agree with each other closely. The parametric study using the theoretical approach indicates the close relationships among the global impact responses (including the maximum impact force and the maximum global displacement) in specimens with the equivalent thicknesses, proposed in the theoretical model, for the pipe-in-pipe composite structures. In the pipe-in-pipe composite structure, the inner steel pipe, together with the outer steel pipe, imposes a strong confinement on the infilled cement composite and enhances significantly the composite action, leading to improved impact resistance, small global and local deformations.
Du, J.,Zhao, G.,Pang, H.,Qian, Y.,Liu, H.,Kang, D.J. North-Holland 2013 Materials letters Vol.93 No.-
Porous Sn-doped TiO<SUB>2</SUB> monoliths were fabricated with polystyrene spheres as a template using a sol-gel method, and followed by calcination at high temperature. Sn doping can suppress the electron/hole recombination through facilitating charge rectification. And its porous structure can provide large surface areas, leading to more adsorption and fast transfer of pollutants. The Sn-doped TiO<SUB>2</SUB> monoliths were characterized by XRD, SEM and BET measurements. In order to evaluate the photocatalytic activity of porous Sn-doped TiO<SUB>2</SUB> monoliths, the photodegradation for methyl orange was performed under UV-vis irradiation. At the same conditions, porous Sn-doped TiO<SUB>2</SUB> monoliths showed the better behavior of photodecomposition for organic compounds than Degussa P25.