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Inkyung Park,Seong Min Oh,Kyung Hwa Lee,Soohyun Kim,Jeong Eun Jeon,Ha Young Lee,Sehyun Jeon,Seog Ju Kim,Yu Jin Lee 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.3
Objective: This study was performed to investigate the associations of life event stress with impulsivity, anxiety, and depressed mood as a function of the presence of a sleep disturbance. Methods: In total, 214 participants (age 38.96±10.53 years; 111 females) completed self-report questionnaires, including the Life Experience Survey (LES), Pittsburgh Sleep Quality Index (PSQI), Barratt’s Impulsivity Scale (BIS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). The presence of a sleep disturbance was defined as a PSQI score >5. Results: In total, 127 participants presented with a sleep disturbance (age 39.33±10.92 years; 64 females), whereas the remaining 87 did not (age 38.43±9.97 years; 47 females). Negative LES scores were significantly correlated with BIS (r=0.22, p=0.001), BAI (r=0.46, p< 0.001), and BDI (r=0.51, p<0.001) scores, and PSQI scores were significantly correlated with BAI (r=0.49, p<0.001) and BDI (r=0.60, p< 0.001) scores. Moderation analysis revealed statistically significant interactions between negative LES scores and the presence of a sleep disturbance on BIS (p=0.044) and BDI (p=0.014) but not on BAI (p=0.194) scores. Conclusion: The findings of the present study suggest that life event stress has varying degrees of influence on mental health, especially impulsivity and depressed mood, depending on the presence or absence of a sleep disturbance.
Determinants of nuclear power expansion in Indonesia
Cho, Inkyung,Oh, Surim,Kim, Soohyeon,Ardin, Fadolly,Heo, Eunnyeong Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1
As Indonesia is rich in natural resources, nuclear power remains a low priority among energy alternatives. However, Indonesia needs to introduce nuclear power to improve the atmospheric environment and to support sustainable economic growth. This study conducted a two-stage survey of logit-probit and analytic hierarchy process to analyze the perception of Indonesian energy policymakers regarding the introduction of nuclear power, the potential for change, and key decision factors. The analysis confirms that the perception of nuclear power is positive and that the willingness to expand nuclear power can improve if negative conditions, such as underdeveloped technology level, foreign aid and assistance, and safety issues are addressed. In addition, it is confirmed that the policy makers consider political/social and environmental factors to be more important for decision-making. The results of this study can give inplications and be used as a key reference for Indonesia's nuclear power policy
Song, Inkyung,Oh, Dong-Hwa,Shin, Ha-Chul,Ahn, Sung-Joon,Moon, Youngkwon,Woo, Sun-Hee,Choi, Hyoung Joon,Park, Chong-Yun,Ahn, Joung Real American Chemical Society 2015 NANO LETTERS Vol.15 No.1
<P>Cutting-edge research in the band engineering of nanowires at the ultimate fine scale is related to the minimum scale of nanowire-based devices. The fundamental issue at the subnanometer scale is whether angle-resolved photoemission spectroscopy (ARPES) can be used to directly measure the momentum-resolved electronic structure of a single wire because of the difficulty associated with assembling single wire into an ordered array for such measurements. Here, we demonstrated that the one-dimensional (1D) confinement of electrons, which are transferred from external dopants, within a single subnanometer-scale wire (subnanowire) could be directly measured using ARPES. Convincing evidence of 1D electron confinement was obtained using two different gold subnanowires with characteristic single metallic bands that were alternately and spontaneously ordered on a stepped silicon template, Si(553). Noble metal atoms were adsorbed at room temperature onto the gold subnanowires while the overall structure of the wires was maintained. Only one type of gold subnanowire could be controlled using external noble metal dopants without transforming the metallic band of the other type of gold subnanowires. This result was confirmed by scanning tunnelling microscopy experiments and first-principles calculations. The selective control clearly showed that externally doped electrons could be confined within a single gold subnanowire. This experimental evidence was used to further investigate the effects of the disorder induced by external dopants on a single subnanowire using ARPES.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-1/nl503558g/production/images/medium/nl-2014-03558g_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl503558g'>ACS Electronic Supporting Info</A></P>
Characterization of sphere-forming HCT116 clones by whole RNA sequencing
Eunkyung Chung,Inkyung Oh,Kil Yeon Lee 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.4
Purpose: To determine CD133<SUP>+</SUP> cells defined as cancer stem cells (CSCs) in colon cancer, we examined whether CD133<SUP>+</SUP> clones in HCT116 demonstrate known features of CSCs like sphere-forming ability, chemodrug-resistance, and metastatic potential. Methods: Magnetic cell isolation and cell separation demonstrated that <1% of HCT116 cells expressed CD133, with the remaining cells being CD133<SUP>-</SUP> clones. In colon cancer cells, radioresistance is also considered a CSC characteristic. We performed clonogenic assay using 0–4 Gy g-irradiation. Results: Interestingly, there were no differences between HCT116 parental and HCT116 CD133<SUP>+</SUP> clones when the cells comprised 0.5% of the total cells, and CD133<SUP>-</SUP> clone demonstrated radiosensitive changes compared with parental and CD133<SUP>+</SUP> clones. Comparing gene expression profiles between sphere-forming and nonforming culture conditions of HCT116 subclones by whole RNA sequencing failed to obtain specific genes expressed in CD133<SUP>+</SUP> clones. Conclusion: Despite no differences of gene expression profiles in monolayer attached culture conditions of each clone, sphere-forming conditions of whole HCT116 subclones, parental, CD133<SUP>+</SUP>, and CD133<SUP>-</SUP> increased 1,761 coding genes and downregulated 1,384 genes related to CSCs self-renewal and survival. Thus, spheroid cultures of HCT116 cells could be useful to expand colorectal CSCs rather than clonal expansion depending on CD133 expressions.
An analysis of Cambodia’s policy-maker’s acceptance of renewable and nuclear energy
Kim Soohyeon,Cho Inkyung,Oh Surim,Heo Eunnyeong 한국자원공학회 2022 Geosystem engineering Vol.25 No.1
In recent years, the Cambodian government has been promoting clean energy sources, making it essential to understand better the entry/barrier conditions for greater utilisation of renewable and nuclear power. Accordingly, this study aims to analyse the potential for expanding renewable and nuclear energy use in Cambodia. To derive practical recommendations for the political sector, we surveyed officials from the government and various institutions. Specifically, we measured Cambodia’s acceptance of renewable and nuclear energy, derived entry/barrier conditions, and identified the decision-making priorities of the government in introducing and expanding each energy source. The analysis employed the ordered logit-probit analysis and analytic hierarchy process (AHP). This study provides a practical guide for the Cambodian government, and investors and partners who intend to contribute to the renewable and nuclear systems of the country: renewable energy requires strategies maximising the economic benefits of its rich potential; while nuclear generation needs broad economic and technological cooperation with foreign governments and companies, and preparation for socio-political instability.
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis
Kim, Kiyoon,Yu, Miran,Han, Seulhee,Oh, Inkyung,Choi, Young-Jun,Kim, Sungsoo,Yoon, Kyungsik,Jung, Minhyung,Choe, Wonchae Spandidos Publications 2009 ONCOLOGY REPORTS Vol.21 No.6
<P>Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer. We found strong pattern of increased Prx II and III immunostaining with increasing severity of the lesion. No difference in staining intensity by grade of lesion was observed for Prx I, and IV. Therefore, we conclude that Prx II and III are upregulated in response to the development of cervical cancer.</P>