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Review Article : Low Salt Diet and Insulin Resistance
( Hyunwoo Oh ),( Hyo Young Lee ),( Dae Won Jun ),( Seung Min Lee ) 한국임상영양학회 2016 Clinical Nutrition Research Vol.5 No.1
It is well known that high sodium intake is closely associated with the risk of cardiovascular disease, but the effect of low sodium intake on insulin resistance is not clear. In this article, we summarize findings from previous studies focusing on the association between low sodium intake and insulin resistance. While many investigations on this topic have been conducted actively, their major findings are inconsistent, partly due to different study designs. Thus, additional randomized controlled trials with an adequate study period and reasonable levels of low sodium intake are needed.
A Pilot Project of Systematic Tuberculosis Screening in the Elderly in a South Korean Province
( Hyunwoo Kim ),( Hee-jin Kim ),( Kyung-hyun Oh ),( Hwan-wook Oh ),( Hongjo Choi ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Tuberculosis (TB) is a major infectious disease in South Korea causing substantial disease burden, particularly in the elderly. This study aimed to identify the case detection rate of mobile TB screening for the elderly conducted in the Jeollanam-do region and to analyze risk factors of active TB. Methods: We screened the elderly population (≥65 years old) in Jeollanam-do from August to December 2017. Chest radiography was performed for all participants. Participants with TB presumptive signs were asked to submit sputum specimen(s). Sputum smear, culture, and polymerase chain reaction analyses were performed. Cascade analysis, chisquared tests, and Fisher exact tests were used to evaluate screening performance. Results: In total, 12,402 participants were screened, and 211 (1.7%) were suspected to have active TB; 181 of the suspected patients (85.8%) underwent sputum smear test, and 16 (8.8%) patients were confirmed to have TB. The TB prevalence among the elderly was bacteriologically confirmed to be 129 per 100,000 individuals, which was similar to national TB notification data for the same age groups. The proportion of active TB cases increased with age, and differed based on sex and past TB history. However, TB-related symptoms, comorbidity status, and TB screening history within 12 months were not predictive of active TB. Conclusion: This study identified that the prevalence rate was similar to national TB notification data from the same age groups. Periodic, community-based, systematic TB screening among the elderly population is recommended.
Oh, Hyunwoo,Kim, Jooheon Elsevier Applied Science Publishers 2019 Composites science and technology Vol.172 No.-
<P><B>Abstract</B></P> <P>Heat management is considered to be a critical issue for the efficient integration of electronic devices, and the demand for materials with high thermal conductivity is increasing. Therefore, various thermally conductive fillers have been developed to enhance the heat flow in polymer composites. However, boron nitride (BN), a thermally conductive filler has low compatibility with polymer matrix, which causes interfacial phonon scattering and interferes with the heat transfer performance. In this study, BN/polymethyl methacrylate (PMMA) composites with high thermal conductivity were prepared using a simple in-situ polymerization process and a hot-pressing method. The surface of BN was silanized with vinyltriethoxysilane to introduce double bonds, and it was directly linked with the polymer chains during the polymerization step. As a result, at a BN content of 70 wt%, the composite exhibited an obvious thermal conductivity enhancement, with a value that was 17.8 times higher than that of PMMA. In addition, our composites were also compared to other BN/PMMA composites fabricated with conventional melt-mixing and showed higher thermal conductivities.</P>
Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
( Hyunwoo Oh ),( Dae Won Jun ),( Waqar K Saeed ),( Mindie H Nguyen ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.3
The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be 25-30% of the population, and is the most common cause of elevated liver enzymes in Korea. NAFLD is a “hot potato” for pharmaceutical companies. Many clinical trials are underway to develop a first-in-class drug to treat NAFLD. However, there are several challenging issues regarding the diagnosis of NAFLD. Currently, liver biopsy is the gold standard method for the diagnosis of NAFLD and steatohepatitis. Ideally, globally recognized standards for histological diagnosis and methods to optimize observer agreement on biopsy interpretation should be developed. Liver biopsy is the best method rather than a perfect one. Recently, multi-parametric magnetic resonance imagery can estimate the amount of intrahepatic fat successfully and is widely used in clinical trials. But no diagnostic method can discriminate between steatohepatitis and simple steatosis. The other unresolved issue in regard to NAFLD is the absence of satisfactory treatment options. Vitamin E and obeticholic acid have shown protective effects in randomized controlled trials, but this drug has not been approved for use in Korea. This study will provide a description of diagnostic methods and treatments that are currently recommended for NAFLD. (Clin Mol Hepatol 2016;22:327-335)
The effects of moderate alcohol consumption on non-alcoholic fatty liver disease
Hyunwoo Oh,Won Sohn,Yong Kyun Cho 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.-
Non-alcoholic fatty liver disease (NAFLD) is accepted as a counterpart to alcohol-related liver disease because it is defined as hepatic steatosis without excessive use of alcohol. However, the definition of moderate alcohol consumption, as well as whether moderate alcohol consumption is beneficial or detrimental, remains controversial. In this review, the findings of clinical studies to date with high-quality evidence regarding the effects of moderate alcohol consumption in NAFLD patients were compared and summarized.
A Pilot Project of Systematic Tuberculosis Screening in the Elderly in a South Korean Province
Kim, Hyunwoo,Kim, Hee-Jin,Oh, Kyung-Hyun,Oh, Hwan-Wook,Choi, Hongjo The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Tuberculosis (TB) is a major infectious disease in South Korea causing substantial disease burden, particularly in the elderly. This study aimed to identify the case detection rate of mobile TB screening for the elderly conducted in the Jeollanam-do region and to analyze risk factors of active TB. Methods: We screened the elderly population (${\geq}65$ years old) in Jeollanam-do from August to December 2017. Chest radiography was performed for all participants. Participants with TB presumptive signs were asked to submit sputum specimen(s). Sputum smear, culture, and polymerase chain reaction analyses were performed. Cascade analysis, chi-squared tests, and Fisher exact tests were used to evaluate screening performance. Results: In total, 12,402 participants were screened, and 211 (1.7%) were suspected to have active TB; 181 of the suspected patients (85.8%) underwent sputum smear test, and 16 (8.8%) patients were confirmed to have TB. The TB prevalence among the elderly was bacteriologically confirmed to be 129 per 100,000 individuals, which was similar to national TB notification data for the same age groups. The proportion of active TB cases increased with age, and differed based on sex and past TB history. However, TB-related symptoms, comorbidity status, and TB screening history within 12 months were not predictive of active TB. Conclusion: This study identified that the prevalence rate was similar to national TB notification data from the same age groups. Periodic, community-based, systematic TB screening among the elderly population is recommended.
저탄수화물-고지방 다이어트와 지방간의 관계; 통념과 진실
오현우 ( Hyunwoo Oh ),안재희 ( Jaehee Ahn ),전대원 ( Dae Won Jun ) 대한내과학회 2017 대한내과학회지 Vol.92 No.2
Reducing caloric intake is important for weight loss and obesity; a reduction of ~500-700 kcal/day has been recommended previously. However, only a minority of individuals can successfully sustain such a reduced caloric intake. Therefore, many speci-alized diet programs have been proposed. Until now, many experts have recommended low-fat diets in various countries, but very-low-carbohydrate diets have recently garnered attention in Korea. The various effects of changing the dietary compositions of macro- and micronutrients have been debated. The majority of large-scale studies have demonstrated that total caloric intake, rather than the composition of macronutrients or the consumption of a specialized diet, is important for successful weight loss. While many cross-sectional studies have investigated specialized diet programs for patients with non-alcoholic liver disease, no random-ized controlled studies have been performed, except for some that investigated the effect of high consumption of unsaturated fatty acids as part of the Mediterranean diet. (Korean J Med 2017;92:112-117)