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Hyunah Kim,Hyun Kyung Kim,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
The two spotted mite, Tetranychus urticae Koch, is a global pest, and has developed severe resistance to several types of acaricides. Acequinocyl-resistant strain and bifenazate-resistant strain of T. urticae showed higher relative activity level of glutathion-S-transferases (GSTs) than susceptible strain. Studies of resistance in T. urticae have focused on classical detoxifying enzyme system, such as GSTs. We examined the expression of six GSTs genes in T. urticae belong to five different cytosolic classes, including two in delta, one in omega, one in mu, one in zeta, and one mitochondrial GSTs class, kappa. RT-qPCR results showed that, among these six GSTs genes, the relative expression level of delta 1 was significantly higher in bifenazate-resistant strain than in other strains (susceptible, abamectin, acequinocyl, etoxazole and pyridaben strain). Expression level of the delta 2 was also higher in acequinocyl-resistant strain than in other strains. The elevated GSTs gene transcripts following exposure to acequinocyl, bifenazate might be one of the mechanisms involved in detoxification of these acaricide. These results may be caused by different mechanisms in the resistance development of T. urticae to these two different types of acaricides.
Future Prospects of Health Management Systems Using Cellular Phones
Kim, Hun-Sung,Hwang, Yunji,Lee, Jae-Ho,Oh, Hye Young,Kim, Yi-Jun,Kwon, Hyeon Yoon,Kang, Hyoseung,Kim, Hyunah,Park, Rae Woong,Kim, Ju Han Mary Ann Liebert 2014 TELEMEDICINE JOURNAL AND E HEALTH Vol.20 No.6
<P>Cellular phones enable communication between healthcare providers and patients for prevention, diagnosis, and treatment of diseases. However, few studies have examined the user-friendliness or effectiveness of cellular phone-based medical informatics (CPBMI) for healthcare.</P>
Sung Il Kim,Won Jin Kang,Yeseul Choi,Hyunah Kim,Bueyong Park,Hyun Kyung Kim,Hyun-Ha Koo,Gil-Hah Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
The two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is one of the most important pest species devastating many horticultural and ornamental crops and fruit trees. In the present study, a field strain was collected in January 2001 and has been selected for sixteen years with acequinocyl. The resistance ratio calculated from the LC50 of eggs and adults was 191- and 4,237-fold, respectively. The laboratory-selected acequinocyl resistance (LSAR16) strain was screened with 11 acaricides for cross-resistance. The detoxifying enzyme activities and quantitative real-time PCR analysis were performed in the LSAR16 strain. Crossing experiments revealed that LSAR16 strain was inherited maternally, incompletely dominant and monogenic. Most importantly, we identified two new point-mutations at mitochondrial cytb from acequinocyl resistant T. urticae.
Sung-chan Yang,Byung-Eon Noh,Eun Jung Lee,Bong Gu song,Hyunwoo Kim,Tea-Kyu Kim,Seong Yoon Kim,Won Il Park,Hyung-Woo Lim,Hak Seon Lee,Gi-Hun Kim,Chang won Jang,Jin Hwan Jeon,Se Jin Jeong,Hyunah Kim,Kyu 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04
We performed a survey for flavivirus infection and distribution of Aedes albopictus that known as Zika and Dengue virus vector using black–light trap and BG-sentinel trap around urban area in Korea. Mosquitoes were collected in 27 cities during March to November (twice a month) year 2016. Total numbers of mosquitoes collected 102,102 including 19 species 8 genera during collecting period. Total 21,467 Ae. albopictus was collected that 20,961(24.3%) by BG-sentinel trap and 506 (3.2%) by Black-light trap in urban area. Trap index(trap/night) of Ae. albopictus was showed highest in Hamyang (TI:992.3) and lowest in Taebaek (TI:0.3) there was only collected by Black-light trap. A total of 894 pools from all collecting Ae. albopictus were performed a Flavivirus detection. Flavivirus was not detected during study period. This study may provide basic information for surveillance of imported diseases (include Zika virus) and vectors in Korea.
Kim, Hyunah,Kim, Chayoung The International Promotion Agency of Culture Tech 2021 International Journal of Advanced Culture Technolo Vol.9 No.1
Pervasive enhancement and required enforcement of the Internet of Things (IoTs) in a distributed massively multiplayer online architecture have effected in massive growth of Big-Data in terms of server over-load. There have been some previous works to overcome the overloading of server works. However, there are lack of considered methods, which is commonly applicable. Therefore, we propose a combing Sparse Auto-Encoder and Load-Balancing, which is ProGReGA for Big-Data of server loads. In the process of Sparse Auto-Encoder, when it comes to selection of the feature-pattern, the less relevant feature-pattern could be eliminated from Big-Data. In relation to Load-Balancing, the alleviated degradation of ProGReGA can take advantage of the less redundant feature-pattern. That means the most relevant of Big-Data representation can work. In the performance evaluation, we can find that the proposed method have become more approachable and stable.
Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability
Kim, Hyungmi,Kim, Mi Kyoung,Choo, Hyunah,Chong, Youhoon Elsevier 2016 Bioorganic & medicinal chemistry letters Vol.26 No.14
<P><B>Abstract</B></P> <P>The previously identified Janus kinase 1 (JAK1)-selective inhibitor, 1-(2-aminoethyl)-2-(piperidin-4-yl)-1<I>H</I>-benzo[<I>d</I>]imidazole-5-carboxamide (<B>2</B>), suffered from low cell permeability, which resulted in poor pharmacokinetic properties. In this study, by introducing less polar hydrogen bond donors at <I>N</I> <SUP>1</SUP> (a hydroxyalkyl or a methylaminoalkyl group) and C2 (a cyclohexanol group) positions, a series of novel benzimidazole derivatives were prepared, which exhibited selective JAK1 inhibitory activity (IC<SUB>50</SUB> against JAK1=0.08–0.15μM; JAK1-selectivity=26–40 fold vs JAK2, 12–23 fold vs JAK3, and 38–54 fold vs Tyk2) along with significantly increased lipophilicity (3.3–15.8 times) as well as membrane permeability (6.3–12 times).</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim Hyunah,Jung Da Young,Lee Seung-Hwan,Cho Jae-Hyoung,Yim Hyeon Woo,Kim Hun-Sung 대한의학회 2022 Journal of Korean medical science Vol.37 No.38
Background: We evaluated patients visiting a tertiary university hospital due to a diagnosis of diabetes with a goal of achieving blood glucose control and evaluated blood glucose persistence over 7 years according to the change in blood glucose evident at 3 months after the first visit. Methods: Patients treated from 2009 to 2013 were categorized into four groups according to the change in HbA1c levels during the first 3 months of follow-up (Best_group, ≥ 1.6% decrease; Better_group, 0.5–1.5% decrease; Neutral_group, maintained at −0.4% to +0.4%; Worse_group, ≥ 0.5% increase). Each patient’s blood glucose control status was then monitored for 7 years. The incidence of stroke and acute coronary syndrome during this period was confirmed. Results: Overall, 9,776 patients were included. HbA1c values were lower in the Best_group than in the other groups at all time points (all P < 0.001). The rate of reaching targets of < 6.5% or < 7.0% HbA1c decreased over time; the rate at which the estimated glomerular filtration rate decreased to < 30 or < 60 mL/min/1.73m2 increased over time (all trends, P < 0.01). Conclusion: Blood glucose control status in the first 3 months after initiating hospital care enabled estimation of the patient’s glycemic control status for the next 7 years. In cases with poor initial blood glucose control, a new or more active method of blood glucose control should be sought.
Kim, Kyoungdo,Park, Kwang-su,Kim, Mi Kyoung,Choo, Hyunah,Chong, Youhoon The Royal Society of Chemistry 2015 Organic & Biomolecular Chemistry Vol.13 No.37
<P>A series of novel J147 derivatives were synthesized, and their inhibitory activities against β-amyloid (Aβ) aggregation and toxicity were evaluated by using the oligomer-specific antibody assay, the thioflavin-T fluorescence assay, and a cell viability assay in the transformed SH-SY5Y cell culture. Among the synthesized J147 derivatives, <B>3j</B> with a 2,2-dicyanovinyl substituent showed the most potent inhibitory activity against Aβ<SUB>42</SUB> oligomerization (IC<SUB>50</SUB> = 17.3 μM) and Aβ<SUB>42</SUB> fibrillization (IC<SUB>50</SUB> = 10.5 μM), and disassembled the preformed Aβ<SUB>42</SUB> fibrils with an EC<SUB>50</SUB> of 10.2 μM. Finally, we confirmed that <B>3j</B> is also effective at preventing neurotoxicity induced by Aβ<SUB>42</SUB>-oligomers as well as Aβ<SUB>42</SUB>-fibrils.</P> <P>Graphic Abstract</P><P>AJ147 derivative <B>3j</B> inhibits Aβ<SUB>42</SUB> oligomerization and fibrillization, disassembles the preformed Aβ<SUB>42</SUB> fibrils and prevents Aβ<SUB>42</SUB> induced neurotoxicity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5ob01463h'> </P>