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A giant solitary vellus hair cyst on the nasal root
Choi, Jong Yun,Cha, Won Jin,Kwon, Hyo Jeong,Seo, Bommie Florence,Kwon, Ho,Jung, Sung-No Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.5
Eruptive vellus hair cyst is a rare lesion of the vellus hair follicles as a result of developmental abnormality. This cyst is usually found in children, adolescents, and young adults most commonly involving the chest, upper and lower extremities, and abdomen. Herein, we introduce a 22-year-old male patient with a mass of nasal root, growing since childhood. The mass has grown over the years, causing the protruding of the nasal root contours, leading to decline in the patient's aesthetic and mental quality of life. In response, we performed complete resection of the mass, which pathologically was a vellus hair cyst. The patient is now satisfied with his appearance and there was no local recurrence during follow up.
Won-Bin Lee,Hyun-Jun Choi,Young-Pyo Cho,Myung-Hyo Ryu,Jee-Hoon Jung 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2
The practical design methodology of a three-phase dual active bridge (3ph-DAB) converter applied to low voltage direct current (LVDC) applications is proposed by using a mathematical model based on the steady-state operation. An analysis of the small-signal model (SSM) is important for the design of a proper controller to improve the stability and dynamics of the converter. The proposed lead-lag controller for the 3ph-DAB converter is designed with a simplified SSM analysis including an equivalent series resistor (ESR) for the output capacitor. The proposed controller can compensate the effects of the ESR zero of the output capacitor in the control-to-output voltage transfer function that can cause high-frequency noises. In addition, the performance of the power converter can be improved by using a controller designed by a SSM analysis without additional cost. The accuracy of the simplified SSM including the ESR zero of the output capacitor is verified by simulation software (PSIM). The design methodology of the 3ph-DAB converter and the performance of the proposed controller are verified by experimental results obtained with a 5-kW prototype 3ph-DAB converter.
Hyo-Rim Lee,Sung-Chan Lee,Dong Ha Lee,Won-Sil Choi,Chan-Sik Jung,Jae-Ho Jeon,Jeong-Eun Kim,Il-Kwon Park 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10
In this study, we isolated and identified an aggregation-sex pheromone from Monochamus saltuarius, the major insectvector of the pine wood nematode in Korea. Adult male of M. saltuarius produces 2-undecyloxy-1-ethanol, which is knownto be an aggregation-sex pheromone in other Monochamus species. We performed field experiments to determine the attractivenessof the pheromone and other synergists. More M. saltuarius adult beetles were attracted to traps baited with the pheromonethan to unbaited traps. Ethanol and (-)-α-pinene interacted synergistically with the pheromone. Traps baited with pheromone+(-)-α-pinene+ethanol were more attractive to M. saltuarius adults than traps baited with pheromone, (-)-α-pinene, or ethanol alone.Ipsenol, ipsdienol, and limonene were also identified as synergists of the aggregation-sex pheromone for M. saltuarius adults.
Hyo-Jin Choi,Kwang-Won Seo,Kye-Hwan Gil,Seung-Hwan Kim,Heung-Sik Kang 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.6
The Pohang Accelerator Laboratory’s X-ray free-electron laser (PAL-XFEL), a 4th generation light source, is currently being installed and will be completed by December 2015 so that users can be supported beginning in 2016. The PAL-XFEL equipment must continuously maintain the bunch-tobunch beam parameters (60 Hz, Energy: 10 GeV, Charge: 200 pC, Bunch Length: 60 fs, Emittance X/Y: 0.481/0.256 mm rad) in order to supply stable photons with the energy and flux appropriate for tests by beamline users. To this end, the PAL-XFEL equipment has to be kept precisely aligned (Linear Accelerator: +/− 100 μm, Undulator: +/− 50 μm). As a part of the process for installing the PAL-XFEL, a GPS-using surface geodetic network is being constructed for precise equipment measurement and alignment, and the installation of a tunnel measurement network inside the buildings is in the preparation stage; additionally, the fiducialization of major equipment is underway. After the PAL-XFEL equipment is optimized and aligned, if the ground and the buildings go through vertical changes during operation, misalignment (and tilt) of the equipment, including various magnets and RF structures, will cause errors in the electron beam’s trajectory, which will lead to changes to the beam parameters. For continuous and systemic measurement of vertical changes in the buildings and monitoring of ground sinking and uplifting, the Budker Institute of Nuclear Physics (BINP) Ultrasonic-type Hydrostatic Levelling System (HLS) is to be installed and operated in all sections of the PAL-XFEL for the linear accelerator, the insertion device (undulator) and the beamline. This study will introduce the operation principle, design concept, and advantages (self-calibration) of the HLS and will outline its installation plan and operation plan.
Inhibition of Tyrosinase Activity by Polyphenols of Chestnut Leaf
Choi, Sang-Won,Kim, Hyo-Jin 대구효성가톨릭대학교 응용과학연구소 1998 응용과학연구논문집 Vol.6 No.2
밤잎으로부터 분리된 7가지 polyphenol 화합물의 tyrosinase 저해효과를 mushroom tyrosinase를 사용한 in vitro assay을 이용하여 측정하였다. 먼저 밤잎의 아세톤추출물을 에테르, 에틸아세테이트 및 부탄올 순서대로 용매 분획하여 에틸아세테이트 분획을 얻었다. 다음 이 분획을 Sep-pak C_18 cartridge, HPLC 및 TLC를 이용하여 7가지 페놀화합물, gallic acid(GA), methyl gallate(MG), (+)-catechin(C), (-)-epicatechin(EC), (-)-epicatechin gallate(ECg), (-)-epigallocatechin(EGC) 및 (-)-epigallocatechin gallate(EGCg)을 각각 분리하였다. GA 및 EC는 그들의 gallate 화합물, MG, ECg 및 EGCg 보다 효소 저해활성이 훨씬 낮았다. 그리고 비록 3개의 gallate 화합물에서 서로 유의적인 효소 저해활성의 차이는 보이지 않았지만, MG가 모든 화합물 중 가장 높은 저해활성을 나타내었다. 이러한 결과를 미루어 볼 때 밤잎추출물의 tyrosinase에 대한 강한 저해작용은 잎에 존재하는 3가지 gallate 화합물에 의해 기인된 것으로 생각된다. Tyrosinase inhibitory effect of seven different polyphenols isolated from chestnut(Castanea crenata) leaf was determined using commercially available mushroom tyrosinase in an in vitro assay. The acetone extract of chestnut leaf was partitioned with ethyl ether, ethyl acetate, and n-butanol, stepwisely. The EtOAc fraction was further fractionated and isolated by Sep-Pak c_18 cartridges, HPLC and TLC to give seven different polyphenols, such as gallic acid(GA), methyl gallate(MG), (+)-catechin(C), (-)-epicatechin(EC), (-)-epicatechin gallate(ECg), (-)-epigaalocatechin(EGC) and (-) -epigallocatechin gallate(EGCg). CA, C, and EC are much less tyrosinase inhibitory activity than their gallates, MG, ECg, and EGcg. Especially, methyl gallate showed the strongest inhibitory activity against mushroom tyrosinase, although there were no significant differences of inhibition among three gallate compounds. These results suggest that three gallates, such as methyl gallate, ECg, and EGCg may be mainly responsible for strong tyrosinase inhibitory action of chestnut leaf extract.
Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders
( Hyo Jeong Lee ),( Jong Kyoung Choi ),( Han Seung Ryu ),( Chang Hwan Choi ),( Eun Hee Kang ),( Kyung Sik Park ),( Yang Won Min ),( Kyoung Sup Hong ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.1
Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation. (J Neurogastroenterol Motil 2017;23:9-19)
( Hyo Sang Jo ),( Duk-soo Kim ),( Eun Hee Ahn ),( Dae Won Kim ),( Min Jea Shin ),( Su Bin Cho ),( Jung Hwan Park ),( Chi Hern Lee ),( Eun Ji Yeo ),( Yeon Joo Choi ),( Hyeon Ji Yeo ),( Christine Seok Y 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.11
Oxidative stress is closely associated with various diseases and is considered to be a major factor in ischemia. NAD(P)H: quinone oxidoreductase 1 (NQO1) protein is a known antioxidant protein that plays a protective role in various cells against oxidative stress. We therefore investigated the effects of cell permeable Tat-NQO1 protein on hippocampal HT-22 cells, and in an animal ischemia model. The Tat-NQO1 protein transduced into HT-22 cells, and significantly inhibited against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced cell death and cellular toxicities. Tat-NQO1 protein inhibited the Akt and mitogen activated protein kinases (MAPK) activation as well as caspase-3 expression levels, in H<sub>2</sub>O<sub>2</sub> exposed HT-22 cells. Moreover, Tat-NQO1 protein transduced into the CA1 region of the hippocampus of the animal brain and drastically protected against ischemic injury. Our results indicate that Tat-NQO1 protein exerts protection against neuronal cell death induced by oxidative stress, suggesting that Tat-NQO1 protein may potentially provide a therapeutic agent for neuronal diseases. [BMB Reports 2016; 49(11): 617-622]
( Hyo Bin Lee ),( Ho Suk Choi ),( Won Seob Shin ) 대한물리치료학회 2018 대한물리치료학회지 Vol.30 No.5
Purpose: The aims of this study were to determine if game-based training with constraint-induced movement therapy (CIMT) is effective in improving the balance ability in female patients with a total knee replacement, and to provide clinical knowledge of CIMT game-based training that allows the application of total knee replacement. Methods: Thirty-six patients who had undergone a total knee replacement were assigned randomly to CIMT game training (n=12), general game training (n=12), and self-exercise (n=12) groups. All interventions were conducted 3 times a week for 4 weeks. All patients used a continuous passive motion machine 5 times a week and 2 times a day for 4 weeks. The visual analog scale (VAS), muscle strength of knee flexion and extension, and range of motion (ROM) of knee flexion and extension were assessed, and the functional reach test (FRT), and timed up and go (TUG) test were performed to evaluate the balance ability. Results: All 3 groups showed significant improvement in the VAS, knee flexion and extension muscle strength, FRT, and TUG test after the intervention (p<0.05). Post hoc analysis revealed significant differences in FRT, and TUG of the CIMT game training group compared to the other group (p<0.05). Conclusion: Although the general game training and CIMT game training improved both the knee extension muscle strength and dynamic balance ability, CIMT game training had a larger effect on dynamic balance control.
( Hyo Won Kim ),( Seung Hyun Shin ),( Hae Kyung Woo ),( Eui Kyung Choi ),( In Gu Song ),( Young Hwa Jung ),( Seung Han Shin ),( Eu-kyung Kim ),( Han-suk Kim ) 대한주산의학회 2016 大韓周産醫學會雜誌 Vol.27 No.3
Purpose: The objective of this study was to determine factors associated with respiratory insufficiency and long term ventilator-support in newborn with omphalocele. Methods: Medical records of neonates with omphalocele in the neonatal intensive care unit (NICU) in Seoul National University Children’s Hospital between April 2000 and March 2016 were reviewed retrospectively. Results: A total of 44 neonates were enrolled. Infants intubated within 24 hours after birth (early intubated group, n=21) and not intubated within 24 hours after birth (late intubated group n=23) were compared. Duration of ventilator care, duration of total parenteral nutrition administration, duration of NICU stay and mortality rate were higher in the early intubated group. The early intubated group had lower gestational age, lower birth weight, lower 1min and 5min Apgar score and higher mortality rate with longer duration of mechanical ventilator support than late intubated group. Persistent pulmonary hypertension and small for gestational age were related to the duration of ventilator support. Conclusion: It is important to predict and prevent of respiratory insufficiency and prolongation of invasive mechanical ventilation in neonates with omphalocele. It is needed to diagnose pulmonary hypertension and respiratory failure after birth in early stages. Further prospective large cohort studies are needed to determine the pathophysiology of respiratory insufficiency and ventilator dependency of neonates with omphalocele reducing morbidity.