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Hyesoo Jeon,Shin-Hyeok Park,Sohae Cho,Sol Jeong,Nam Geun Cho 대한침구의학회 2023 대한침구의학회지 Vol.40 No.2
Herein, we report the effectiveness of Korean medicine for the treatment of postherpetic upper limb weakness and pain. The patient received a combination of Korean medicine treatment modalities, including electroacupuncture, pharmacopuncture, and herbal medicine. Muscle strength and pain were evaluated using a manual muscle test (MMT) and a Numerical Rating Scale (NRS), respectively. The overall MMT score improved after hospitalization, and elbow extension improved from 3+ at admission to 5 at discharge. The NRS score improved to 2 at discharge. This study suggests the effectiveness of a combination of Korean medicine modalities in treating postherpetic motor nerve paralysis.
Eunbyul Cho,Shin-Hyeok Park,Hyesoo Jeon,Nam Geun Cho 대한침구의학회 2023 대한침구의학회지 Vol.40 No.1
Very few studies have been reported on upper extremity replantation following traumatic amputation. This case study aimed to report the progress of a patient treated with complex Korean medicine for 1 year after elbow replantation. The patient mainly complained of forearm sensory loss, muscle weakness, and hand pain after undergoing upper limb amputation and emergency replantation. He was hospitalized for approximately 50 days and then received outpatient treatment for approximately 10 months, followed by electroacupuncture, moxibustion, Chuna, herbal medicine, and transcutaneous electrical nerve stimulation. The muscle strength of the wrist joint improved to good (flexion) and fair (extension), and the forearm sensation was partially recovered approximately 10 months after the onset. To our knowledge, this is the first case report on replantation rehabilitation in Korean medicine, and it suggests that complex Korean medicine treatment might be beneficial for patients undergoing replantation after upper extremity amputation.
Lee, Sangwoo,Kim, Cheolmin,Shin, Hyesoo,Kho, Younglim,Choi, Kyungho Elsevier 2019 CHEMOSPHERE - Vol.221 No.-
<P><B>Abstract</B></P> <P>Several structural analogues of bisphenol A (BPA), e.g., bisphenol F (BPF), bisphenol S (BPS), and bisphenol Z (BPZ), have been used as its substitutes in many applications and consequently detected in the environment, and human specimen such as urine and serum. While BPA has been frequently reported for thyroid hormone disruption in both experimental and epidemiological studies, less is known for the BPA analogues. In the present study, thyroid hormone disrupting effects of BPF, BPS and BPZ, were investigated, and compared with those of BPA, using embryo-larval zebrafish (<I>Danio rerio</I>). At 120 hpf, significant increases in T3 and/or T4 were observed in the larval fish following exposure to BPA, BPF, or BPS. Moreover, transcriptional changes of the genes related to thyroid development (<I>hhex</I> and <I>tg</I>), thyroid hormone transport (<I>ttr</I>) and metabolism (<I>ugt1ab</I>) were observed as well. Thyroid hormone (T4) disruption by BPF was observed even at the concentration (2.0 mg/L) lower than the effective concentration determined for BPA (>2.0 mg/L). Delayed hatching was observed by all tested bisphenols. Our results clearly show that these BPA analogues can disrupt thyroid function of the larval fish, and their thyroid hormone disruption potencies could be even greater than that of BPA. The concentrations which disrupt thyroid function of the larval fish were orders of magnitude higher than those occurring in the ambient environment. However, thyroid hormone disruption by longer term exposure and its consequences in the fish population, deserve further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thyroid disruption of three BPA substitutes was studied. </LI> <LI> BPA, BPF, and BPS significantly increased T3 and/or T4 levels in larval zebrafish. </LI> <LI> The genes related to TH synthesis were also up-regulated. </LI> <LI> Hatching delay was also observed in larval fish after exposure. </LI> <LI> Similar to BPA, several BPA analogues are thyroid disruptors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>