Adenosine triphosphate-based chemotherapy response assay-guided chemotherapy in unresectable colorectal liver metastasis

Hur, H,Kim, N K,Kim, H G,Min, B S,Lee, K Y,Shin, S J,Cheon, J H,Choi, S H Nature Publishing Group 2012 The British journal of cancer Vol.106 No.1

<P><B>Background:</B></P><P>This study aims to evaluate the effectiveness of adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided neoadjuvant chemotherapy for increasing resectability in patients with unresectable colorectal liver metastasis.</P><P><B>Patients and methods:</B></P><P>Patients were randomised into two groups: Group A was treated by conventional chemotherapy regimen and Group B was treated by chemotherapy regimen according to the ATP-CRA. Three chemotherapeutic agents (5-fluorouracil, oxaliplatin and irinotecan) were tested by ATP-CRA and more sensitive agents were selected. Either FOLFOX or FOLFIRI was administered. Between Group A and B, treatment response and resectability were compared.</P><P><B>Results:</B></P><P>Between November 2008 and October 2010, a total 63 patients were randomised to Group A (<I>N</I>=32) or Group B (<I>N</I>=31). FOLFOX was more preferred in Group A than in Group B (26 out of 32 (81.3%) <I>vs</I> 20 out of 31 (64.5%)). Group B showed better treatment response than Group A (48.4% <I>vs</I> 21.9%, <I>P</I>=0.027). The resectability of hepatic lesion was higher in Group B (35.5% <I>vs</I> 12.5%, <I>P</I>=0.032). Mean duration from chemotherapy onset to the time of liver resection was 11 cycles (range 4–12) in Group A and 8 cycles (range 8–16) in Group B.</P><P><B>Conclusion:</B></P><P>This study showed that tailored-chemotherapy based on ATP-CRA could improve the treatment response and resectability in initially unresectable colorectal liver metastasis.</P>

Analysis of HOX Gene Expression Patterns in Human Breast Cancer

Hur, H.,Lee, J. Y.,Yun, H. J.,Park, B. W.,Kim, M. H. HUMANA PRESS 2014 Molecular biotechnology Vol.56 No.1

HOX genes are highly conserved transcription factors that determine the identity of cells and tissues along the anterior-posterior body axis in developing embryos. Aberrations in HOX gene expression have been shown in various tumors. However, the correlation of HOX gene expression patterns with tumorigenesis and cancer progression has not been fully characterized. Here, to analyze putative candidate HOX genes involved in breast cancer tumorigenesis and progression, the expression patterns of 39 HOX genes were analyzed using breast cancer cell lines and patient-derived breast tissues. In vitro analysis revealed that HOXA and HOXB gene expression occurred in a subtype-specific manner in breast cancer cell lines, whereas most HOXC genes were strongly expressed in most cell lines. Among the 39 HOX genes analyzed, 25 were chosen for further analysis in malignant and non-malignant tissues. Fourteen genes, encoding HOXA6, A13, B2, B4, B5, B6, B7, B8, B9, C5, C9, C13, D1, and D8, out of 25 showed statistically significant differential expression patterns between non-malignant and malignant breast tissues and are putative candidates associated with the development and malignant progression of breast cancer. Our data provide a valuable resource for furthering our understanding of HOX gene expression in breast cancer and the possible involvement of HOX genes in tumor progression.

Molecular Mechanism of Dioxin-induced Endocrine Disruption through Induction of Oxidative Estrogen Metabolism

Hurh Yeon-Jin,Cho Myung-Haing,Surh Young-Joon 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

Optical gain and penalty characteristics of a fiber-Bragg-grating based active optical-add-drop multiplexer

Hurh, Yoon-Suk,Seo, Kyung-Hee,Lee, Jae-Seung The Optical Society 2009 Optics express Vol.17 No.24

<P>We investigate optical gain and penalty characteristics of a fiber-Bragg-grating based active optical-add-drop multiplexer (OADM). The active OADM has a two-stage structure and can amplify all the add/drop/thru channels simultaneously. The drop-channel penalty is a key parameter for the reliable operation of the active OADM. This penalty, caused mainly by multiple reflections within the active OADM, can be minimized adjusting pump powers. At the minimum drop-channel penalty, our active OADM shows fairly high optical gains as 15.5, 21, and 19.4 dB for the add, drop, and thru channels, respectively. Nevertheless, the penalties of these channels are comparable to the passive OADM.</P>

Using Minute Papers to Improve Lecture Demonstrations

Hurh, Eunyoung,Soman, Sherril A.,Robinson, William R. 한국과학교육학회 2005 한국과학교육학회지 Vol.25 No.1

Minute papers are brief papers written at the end of a lecture in response to one or two questions posed by the instructor. The answers are discussed briefly at the beginning of the next lecture. We used minute papers to follow students' understanding and response to lecture demonstrations in an introductory general chemistry course. An analysis of these minute papers suggest that the following characteristics are important, when using demonstrations as teaching aids. 1) The purpose of a demonstration should be stated as explicitly as possible. 2) Instructors should be explicit about what is happening and what students should be looking for .3) Demonstrations should be kept as simple as possible, perhaps illustrating one concept. Finally, we note that students believe that the visual component of demonstrations enhances their comprehension of chemistry concepts.

Weather-insensitive optical free-space communication using gain-saturated optical fiber amplifiers

Hurh, Yoon-Suk,Shin, Kyung-Woon,Lee, Sang-Hoon,Lee, Jae-Seung IEEE 2005 Journal of Lightwave Technology Vol.23 No.12

This paper presents a weather-insensitive optical free-space communication (OFSC) method supporting optical packet channels. It operates optical fiber amplifiers (OFAs) used as boosters in gain-saturation regions. When the propagation loss gets too high, it decreases the average packet rate, or the average packet length, or both, to increase the optical power level launched into the free space. As a demonstration, 8 × 10 Gigabit-Ethernet (GbE) channels were transmitted over a terrestrial distance of 2.4 km. One gain-saturated free-space optical repeater is used at the halfway.

Facile reduction and stabilization of ginsenoside-functionalized gold nanoparticles: optimization, characterization, and in vitro cytotoxicity studies

Hurh, Joon,Markus, Josua,Kim, Yeon-Ju,Ahn, Sungeun,Castro-Aceituno, Veronica,Mathiyalagan, Ramya,Kim, Yu Jin,Yang, Deok Chun KLUWER 2017 JOURNAL OF NANOPARTICLE RESEARCH Vol. No.

<P>Gold nanoparticles (GNPs) are forecasted to provide an attractive platform in biomedicine and catalysis with their potentials of combining a variety of biophysicochemical properties into an integrated nanodevice with great therapeutic and optical functions. There are several reports of crude plant extracts mediating the conversion of metal ions into nanoparticles. However, we aimed to investigate the capability of single bioactive compounds, namely ginsenosides compound K (C-K) and Rh2, to accommodate a synergistic chemical reduction of gold salts by one-pot green chemistry. Ginsenosides C-K and Rh2 are unique triterpenoid saponins present in Panax ginseng Meyer, a perennial plant traditionally used as an oriental medicinal herbal with long history. C-K and Rh2 have demonstrated diverse pharmacological properties such as anticancer, anti-inflammation, anti-aging, and neuroprotective properties. The reduction of gold ions by these ginsenosides led to the production of nontoxic GNPs as tested in mousemacrophage (J774A. 1) and human kidney epithelial (HEK-293) in vitro. The kinetics of the bioreduction and the influence of pH were examined by an ultraviolet-visible (UV-Vis) spectrophotometer. GNPs were characterized by field emission transmission electron microscopy (FE-TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and Fourier transform infrared (FTIR) spectroscopy. Ginsenoside loading efficiency of C-K-GNPs and Rh2-GNPs was determined to be approximately 62.83% and 54.91%, respectively, by thermogravimetric analysis (TGA). These results suggest that onepot synthesis by ginsenosides C-K and Rh2may be useful for producing ginsenoside-loaded gold nanocarriers.</P>

Collagens and collagen peptides as modulators of immune responses and cellular signalings

HURH, BYUNG SERK 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.4

Associations of Handgrip Strength and Handgrip Strength Asymmetry With Depression in the Elderly in Korea: A Cross-sectional Study

Hurh, Kyungduk,Park, Yoonsik,Kim, Gyu Ri,Jang, Sung-In,Park, Eun-Cheol The Korean Society for Preventive Medicine 2021 Journal of Preventive Medicine and Public Health Vol.54 No.1

Objectives: Recent studies have suggested that assessing handgrip strength (HGS) asymmetry together with HGS may be helpful for evaluating problems in geriatric patients. This study aimed to identify whether HGS asymmetry, weakness, or both were associated with depression in Korean older adults. Methods: This study included 4274 subjects from the sixth and seventh Korea National Health and Nutrition Examination Survey. Depression was measured using the Patient Health Questionnaire-9. The maximum HGS of the dominant hand was used as a representative value. HGS symmetry was categorized by the ratio of the HGS of the dominant hand to that of non-dominant hand. The odds ratio (OR) for depression was calculated according to the HGS and its symmetry. Results: In total, 240 (12.5%) men and 534 (22.7%) women had depression. HGS or HGS asymmetry showed no statistically significant associations with depression in elderly men. Elevated odds of depression were observed in elderly women with low HGS (OR, 1.93; 95% confidence interval [CI], 1.33 to 2.81) or prominent HGS asymmetry (OR, 1.46; 95% CI, 1.02 to 2.08). There was a positive additive interaction between asymmetric HGS and weakness, as women with low and prominently asymmetric HGS showed higher odds of depression (OR, 3.77; 95% CI, 2.16 to 6.59) than women with high and symmetric HGS. Conclusions: Depression in elderly Korean women was associated with both low and asymmetric HGS. Our findings support the potential value of HGS asymmetry as an indicator of HGS.

어린이집 초임교사의 직업능력발달 특성 연구

허정무(Hurh, Jeong-Moo) 한국영유아보육학회 2012 한국영유아보육학 Vol.0 No.73

이 연구에서는 어린이집 초임교사들의 직업능력발달 수준을 분석하였다. 또한, 어린이집 초임교사들의 교사로서의 입문당시와 현재의 직업능력발달 수준을 비교함으로써 변화 정도를 분석하였다. 분석 결과, 초임교사의 직업능력발달 전체점수 및 하위영역점수 모두에서 변화?발달한 것으로 나타났다. 민간 어린이집에서 근무하는 교사들일수록 국공립 어린이집에서 근무하는 교사들보다 상대적으로 높은 변화?발달경향을 나타냈다. 4년제 대학 출신 교사들 보다 전문대학 출신 교사들일수록 상대적으로 높은 변화?발달경향을 나타냈다. 어린이집 초임교사의 직업능력발달에 관한 연구는 예비교사를 위한 직전교육 프로그램 및 현직교사를 위한 직무능력기반 연수프로그램 개발에 중요한 기초자료가 될 수 있을 것이다. This study analyzed the levels of professional development of childcare teachers hired for the first time. And it analyzed the range of change of job performance by comparing the current level of job performance with the level acquired when they started the first job as a childcare teacher. As a result there was a change and development of total score associated with job performance and sub total. The study showed that job performance by teachers of private childcare center was more developed than by that of public. It showed that job performance by teachers from four year universities was more developed by teachers from community colleges. The study of job performance abilities of childcare teachers hired for the first time is able to provide professors and the candidates of childcare position with important information on childcare process. And the study may provide basic data of training teachers and information on the practice of childcare. Furthermore the study will be able to assist maintaining and developing the quality of childcare education by attracting staff members who are more professional.