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Hoang, Van-Hai,Tran, Phuong-Thao,Cui, Minghua,Ngo, Van T. H.,Ann, Jihyae,Park, Jongmi,Lee, Jiyoun,Choi, Kwanghyun,Cho, Hanyang,Kim, Hee,Ha, Hee-Jin,Hong, Hyun-Seok,Choi, Sun,Kim, Young-Ho,Lee, Jeewoo American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.6
<P>Glutaminyl cyclase (QC) has been implicated in the formation of toxic amyloid plaques by generating the N-terminal pyroglutamate of beta-amyloid peptides (pGlu-A beta) and thus may participate in the pathogenesis of Alzheimer's disease (AD). We designed a library of glutamyl cyclase (QC) inhibitors based on the proposed binding mode of the preferred substrate, A beta 3E-42. An in vitro structure-activity relationship study identified several excellent QC inhibitors demonstrating 5- to 40-fold increases in potency compared to a known QC inhibitor. When tested in mouse models of AD, compound 212 significantly reduced the brain concentrations of pyroform A beta and total A beta and restored cognitive functions. This potent A beta-lowering effect was achieved by incorporating an additional binding region into our previously established pharmacophoric model, resulting in strong-interactions with the carboxylate group of Glu327 in the QC binding site. Our study offers useful insights in designing novel QC inhibitors as a potential treatment option for AD.</P>
A Study on Bandwidth and Buffer Management Mechanisms of IP Networks
Hai, Hoang Dang,Thuong, Pham Van,Hong, You-Sik The Institute of Internet 2010 한국인터넷방송통신학회 논문지 Vol.10 No.2
대역폭 및 버퍼는 엔드-투-엔드 품질 서비스를 결정하기위한 중요한 네트워크 리소스이다. 본 논문에서는 대역폭과 버퍼 관리에 관한 몇 가지 기법에 대해 조사 및 TCP / IP 네트워크의 처리량을 제어에 사용되는 유형에 따라 분류 하고자 한다. 뿐만 아니라, 본 논문에서는 모델링 활성 대역폭을 위한 새로운 접근법을 제시 및 TCP / IP용 네트워크에 대한 버퍼의 제어 메커니즘에 대한 새로운 접근법을 제시한다. Bandwidth and Buffer are critical network resources to determine the end-to-end quality of service. In this paper, we investigate several techniques on bandwidth and buffer management and classify them according to the types they used for controlling the throughput of a TCP/IP network. Moreover, in this paper, it present a new approach for modeling the active bandwidth and buffer control mechanisms for TCP/IP networks.
Analysis on CO2 reforming of CH4 by corona discharge process for various process variables
Hoang Hai Nguyen,김교선,나소노바안나,나인욱 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-
The CO2 reforming of CH4 to syngas by corona discharge at atmospheric pressure has been investigatedfor various process variables. The experiments were operated systematically in wide regions of processvariables such as CO2/CH4 ratio, total flow rate, pulse frequency and applied peak voltage. Theconversions of methane and carbon dioxide increase with increasing the applied peak voltage or pulsefrequency and decrease with increasing the total flow rate. Selectivities of H2 and CO increase with theincrease of applied peak voltage, while increasing total flow rate and pulsed frequency does not affect H2and CO selectivities significantly
A Study on Bandwidth and Buffer Management Mechanisms of IP Networks
Hoang Dang Hai,Pham Van Thuong,You-Sik Hong 한국인터넷방송통신학회 2010 한국인터넷방송통신학회 논문지 Vol.10 No.2
대역폭 및 버퍼는 엔드-투-엔드 품질 서비스를 결정하기위한 중요한 네트워크 리소스이다. 본 논문에서는 대역폭과 버퍼 관리에 관한 몇 가지 기법에 대해 조사 및 TCP / IP 네트워크의 처리량을 제어에 사용되는 유형에 따라 분류 하고자 한다. 뿐만 아니라, 본 논문에서는 모델링 활성 대역폭을 위한 새로운 접근법을 제시 및 TCP / IP용 네트워크에 대한 버퍼의 제어 메커니즘에 대한 새로운 접근법을 제시한다. Bandwidth and Buffer are critical network resources to determine the end-to-end quality of service. In this paper, we investigate several techniques on bandwidth and buffer management and classify them according to the types they used for controlling the throughput of a TCP/IP network. Moreover, in this paper, it present a new approach for modeling the active bandwidth and buffer control mechanisms for TCP/IP networks.
Hoang, Van Minh,Kim, Bao Giang,Phan, Thi Hai,Trinh, Dinh Hoang,Doan, Thu Huyen,Luong, Ngoc Khue,Nguyen, Thuy Linh,Nguyen, Tuan Lam,Pham, Thi Quynh Nga Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Scientific evidence on all aspects of smoking amongst youth is very important for designing appropriate interventions to reduce smoking among this vulnerable population. This paper describes current access to anti-smoking information among school children aged 13 to 15 years in Vietnam in 2014 and examines its potential impact on preventing smoking initiation. The data used in this paper were obtained from the 2014 Global Youth Tobacco Survey (GYTS) in Vietnam. Students were asked questions about their level of awareness of anti-smoking information from various sources in the past 30 days and about lessons in school regarding the dangers of tobacco use during the last 12 months. Those who have never smoked were asked "whether or not they thought about avoiding cigarettes because of health warnings on cigarette packages" and answers were analyzed in combination with data on access to anti-smoking information from other sources. The prevalence of exposure to antismoking campaigns was high among school children in Viet Nam: 55.3% of current smokers reported thoughts of smoking cessation because of health warnings on cigarette packages; 60.5% of never smokers avoided initiating smoking because of the same health warnings. The potential impact of graphic health warnings to prevent school-aged children from smoking initiation would be stronger if there was concurrent access to anti-smoking programs on the dangers of tobacco use in schools. However, school education for tobacco prevention and control has not been as strong as expected. A more comprehensive school curriculum on tobacco prevention and control is recommended to reinforce antismoking messages among school children.
Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
Hai Hoang,강상모,서용권 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.7
We numerically investigate the effect of the solution-wall (i.e., water-wall and ion-wall) interaction potential on the properties of confined aqueous solution by using molecular dynamics (MD) simulations. The effect is determined by comparing results obtained from the MD simulation using the Lennard-Jones (L-J) potential for the water-wall and ion-wall interactions and those using a purely repulsive potential, i.e., the Weeks-Chandler-Andersen-like potential. In the MD simulations, 680 water molecules and 20 chloride ions are included between uniformly charged plates that are separated by 2.6 nm. The results show that the properties of solution are influenced only in the region close to the wall: The water molecules are more densely packed for the case of the L-J potential. Comparison of the results of the MD simulations in the case of the L-J potential with those provided by solving the Poisson-Boltzmann equation, we found that classical continuum theory fails to predict the ion density and electrostatic potential distributions in the region near to the wall, but far way from the wall, the prediction from the continuum theory is in line with the MD simulation.
Vietnam’s Bilateral Defense Diplomacy with Major Powers
Hoang Hai Ha 한국국방연구원 2018 The Korean Journal of Defense Analysis Vol.30 No.4
The paper explores the development of Vietnam’s bilateral defense diplomacy with world and regional powers including the United States, India, and Japan, with a particular focus on the period from 2009 to 2018. The paper nds that Vietnam’s multidirectional defense diplomacy is fundamentally shaped by its historical experience, the contemporary shift in the balance of power and the strategic challenges caused by China’s emerging power. By pursuing a multi–polar balance among major partners, Vietnam avoids being pulled into their rivalry, and keeps its non-alignment as well as strategic autonomy. The international defense cooperation has become further deepened and more substantive to satisfy Vietnam’s strategic interests including national security, territorial integrity, economic development and regime legitimacy. However, domestic and geo–strategic constraints, and asymmetrical economic interdependence with China lead this paper to suppose further challenges in the future of Vietnam’s defense diplomacy.
Hoang Van HAI,Jong Won PARK,Ping-Chen TSAI,Cheoljun EOM 한국재무학회 2020 한국재무학회 학술대회 Vol.2020 No.08
This study investigates the MAX effect regarding lottery mindset in the Chinese stock market. The MAX effect significantly affects stock returns through quintile portfolio and cross-sectional regression analyses. The most-overpriced stock groups, as categorized by mispricing index, show more support for the MAX effect. However, the idiosyncratic volatility (IVOL) effect continues regardless of consideration for the MAX effect, indicating that the MAX effect is not a source of the IVOL effect. Our results suggest that the MAX effect, which is highly relevant for overpriced stocks, might have information for determining stock price, and appears to be independent from information of the IVOL effect in the Chinese stock market.
Hai Le Xuan,Quoc-Dong Hoang,Soon Geul Lee,Dat Pham Xuan,Hoang Tran Viet,Minh Pham Van,Hung Pham Van,Hung Pham Viet,PHAM DUC TUAN,Duc Anh Nguyen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
Ballbots, which have been studied for over ten years, are under-actuated mobile robots that operate using the inverted pendulum paradigm. Controlling a ballbot poses a number of challenges, including maintaining the stable upright posture from the ground in all directions and making sure it follows the desired trajectory. External factors such as a minor change in contact surface properties or fabrication errors can affect the system's stabilization and transfer capabilities. In this study, an adaptive hierarchical sliding mode control algorithm based on an artificial neural network is developed to make the ballbot robust to external factors. The use of the proposed controller ensures system stability despite uncertainties including friction, accidental centrifugal forces and gravity that occur when the ballbot follows the reference trajectory. The system stability is guaranteed on the basis of Lyapunov theory. Control efficiency and robot stability under system uncertainties are demonstrated by numerical simulation.