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- 저자 : Henry Ong (검색결과 2 건)
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A Systematic Review of the Extrahepatic Manifestations of Hepatitis C Infection in East Asia
( Zobair M. Younossi ),( Linda Henry ),( Janus Ong ),( Atsushi Tanaka ),( Yuichiro Eguchi ),( Masashi Mizokami ),( Young-suk Lim ),( Yock Young Dan ),( Ming-lung Yu ),( Maria Stepanova ),( Sooji Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Chronic hepatitis C (CHC) infection causes a systemic infection with hepatic and extrahepatic manifestation (EHMs). Although the prevalence of EHMs in Western countries is well described, the same is not well known in East Asian countries. We performed a systematic review to quantify the prevalence of selected EHMs among CHC patients in East Asia. Methods: PubMed, Medline, and Japan databases searched (1990-Dec 2016) with “hepatitis c virus” “chronic hepatitis C”, “extrahepatic manifestations”, and respective EHM’s. Data were collected and reviewed by two per PRISMA guidelines. EHMs were by ICD-9 codes or clinically: depression:BDI-2 score>19, chronic kidney disease (CKD): eGFR of < 60 mL/ min/1.73 m2 per MDRD, diabetes (DM):fasting blood glucose level > 126 mg/dL. Pooled prevalence determined by random effects models. Results: 75 articles were identified. After applying inclusion and exclusion criteria, 23 articles remained (Japan=6; China=3, Korea= 4, Taiwan=9, Asia=1) with a total of 468,656 subjects (n= 51,160 CHC and n= 417,496 non-HCV controls). HCV patient age ranged from 44-70 (mean age 55), 50% were male (range 0%-67%), and over 80% of diagnosis was established through positive HCV anti-body. CHC subjects had higher risk of lymphoma (n=2) 4.6% vs. 2.3%, OR=1.79 (1.47-2.19), P<0.0001; DM (n=11) 16.7% vs. 9.4%, OR=1.84 (1.52-2.21), P<0.0001; SS (n=2) 9.6% vs. 3.5%, OR=9.80 (1.25-76.56), P=0.0295; LP (n=5) 8.2% vs. 4.2%, OR=2.45 (1.36-4.41), P=0.0027; depression (n=1) 51.6% vs. 27.7%, OR=2.77 (1.25-6.15), P=0.0121; CKD (n=5) 3.8% vs. 1.7%, OR=2.00 (1.09-3.70), P=0.026; RA (n=2) 0.9% vs. 0.3%, OR=2.41 (1.54-3.76), P=0.0001; CVA (n=2) 25.3% vs. 19.3%, hazard ratio 1.38 (1.24-1.53), P<0.05; IHD (n=1) 25.3% vs 11.6%, OR=1.76 (1.04-2.96), P=0. 0.034. Additionally, the prevalence of MC (symptomatic and asymptomatic; n=1) in CHC was 46.9% in CHC vs. 1.9% in general population with a risk ratio of 24.7 (17.2-32.2). Conclusions: Our review found that CHC in East Asia is associated with increased risk for EHMs.
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Status of PEM-based Polarimetric MSE Development at KSTAR
고진석,정진일,Seung Tae Oh,고원하,Maarten de Bock,Henry Ong,Guido Lange 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8
A multi-chord PEM (photo elastic modulator)-based polarimetric motional Stark effect (MSE)system is under development for the KSTAR tokamak. The conceptual design for the front opticswas optimized to preserve not only the polarization state of the input light for the MSE measurementsbut also the signal intensity of the existing charge exchange spectroscopy (CES) system thatwill share the front optics with the MSE. The optics design incorporates how to determine thenumber of channels and the number of fibers for each channel. A dielectric coating will be appliedon the mirror to minimize the relative reflectivity and the phase shift between the two orthogonalpolarization components of the incident light. Lenses with low stress-birefringence constants will beadopted to minimize non-linear and random changes in the polarization through the lenses, whichis a trade-off with the rather high Faraday rotation in the lenses because the latter effect is linearand can be relatively easily calibrated out. Intensive spectrum measurements and their comparisonswith the simulated spectra are done to assist the design of the bandpass filter system that will alsouse tilting stages to remotely control the passband. Following the system installation in 2014, theMSE measurements are expected to be performed during the 2015 KSTAR campaign.
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