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Yoo, Heejung,Kim, Dong-Seok,Shin, Hee-Young,Lai, Jin-Shei,Cella, David,Park, Hyeon-Jin,Ra, Young-Shin,Kim, Woo-Chul,Shin, Yong-Soon Elsevier 2010 Journal of pain and symptom management Vol.40 No.4
<P><B>Abstract</B></P><P>We evaluated the reliability and validity of the Pediatric Functional Assessment of Cancer Therapy-Childhood Brain Tumor Survivor Questionnaire (pedsFACT-BrS, Version 2). This was specifically directed to patients aged 13 years and older (adolescents). The pedsFACT-BrS was translated and cross-culturally adapted into Korean, following standard Functional Assessment of Chronic Illness Therapy methodology. The psychometric properties of the pedsFACT-BrS in adolescents were evaluated in 161 brain tumor (BT) patients (mean age=15.53 years). Pretesting was performed in 30 patients, and the results indicated good symptom coverage and overall comprehensibility. In validating the pedsFACT-BrS for adolescents, we found high internal consistency, with Cronbach's α coefficients ranging from 0.76 to 0.91. The pedsFACT-BrS for adolescents also demonstrated good convergent and divergent validities when correlated with the Revised Children's Manifest Anxiety Scale and the Kovacs' Children's Depression Inventory. The pedsFACT-BrS for adolescents showed good clinical validity and effectively differentiated between clinically distinct patient groups according to Karnofsky score, type of treatment, and treatment on/off status. This reliable and valid instrument can now be used to properly evaluate the quality of life of Korean adolescent BT patients.</P>
A Study on the Improvement Repeatability and Accuracy of the Analysis Method for SF6 of Trace Level
Heejung Yoo,Hongwoo Choe,Sepyo Lee,Jongho Kim,Sangok Han,Sangboom Ryoo 한국도시환경학회 2018 한국도시환경학회지 Vol.18 No.4
Kyoto Protocol, adopted in 1997, set the obligation to reduce CO2, CH4, N2O, HFCs, PFCs, and SF6 in developed countries during 1st promised period. SF6 has been drawing a lot of attention since the Kyoto Protocol because once it is released into the atmosphere, it not only stays in the atmosphere for more than 3,200 years but also emits 22,800 times stronger global warming potential at the same concentrations as CO2 if remains in the atmosphere for 100 years. This study introduces 12 methods for SF6 of measuring trace. SF6 of trace level in the atmosphere correctly, the measurement method was changed and as a result, when the back flush method was applied to the pre-concentration system that used low-temperature concentration and high-temperature desorption system, which used Carboxen-1000 adsorption trap, the effect was the best.
Yang, Heejung,Yoo, Guijae,Kim, Hye Seong,Kim, Jeom Yong,Kim, Sun Ok,Yoo, Young Hyo,Sung, Sang Hyun American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.47
<P>Two ginsenoside derivatives (<B>9</B>, <B>10</B>) along with 10 known ginsenosides (<B>1</B>–<B>8</B>, <B>11</B>, and <B>12</B>) were isolated from BST204, which is a crude ginseng extract fermented by enzyme and acid hydrolysis. The two ginsenosides were determined as 12β,20(<I>S</I>),25-trihydroxydammara-3-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>9</B>) and 12β,20(<I>R</I>),25-trihydroxydammara-3-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>10</B>). Compounds <B>1</B>–<B>12</B> were categorized into stereoisomeric pairs differentiated by <I>R</I>- or <I>S</I>-configuration at C-20, the number or position of sugar residues at C-3 or C-6, and the type of derivative at C-21. Their structure–activity relationship was evaluated by the cell viability assay using HSC-T6 cells. Results showed that 20(<I>S</I>) (<B>3</B> > <B>4</B>, <B>7</B> > <B>8</B>, and <B>9</B> > <B>10</B>), a 2-hydroxy-2-methylbutyl moiety at C-21 (<B>3</B>, <B>7</B> > <B>9</B>), and the number of sugar residues at C-3 (<B>3</B> > <B>7</B>) significantly affected the antiproliferative activity on HSC-T6 cells. The inhibition of the cell proliferation of compound <B>3</B> was assessed by annexin-V/PI staining analysis using flow cytometry.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2012/jafcau.2012.60.issue-47/jf303714c/production/images/medium/jf-2012-03714c_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf303714c'>ACS Electronic Supporting Info</A></P>
Two New Phenolic Glycosides from the Aerial Part of <i>Dryopteris erythrosora</i>
Yoo, Guijae,Park, SeonJu,Yang, Heejung,Nguyen, Xuan Nhiem,Kim, Nanyoung,Park, Jun Hyung,Kim, Seung Hyun Medknow PublicationsMedia Pvt Ltd 2017 Pharmacognosy magazine Vol.13 No.52
<P><B>Background:</B></P><P><I>Dryopteris erythrosora</I> (D.C. Eaton) Kuntze is a species of fern in the family of <I>Dryopteridaceae</I>, which is distributed throughout East Asia. The genus <I>Dryopteris</I> has been used as traditional medicine, especially to treat hepatitis and protect liver. However, only few studies of chemical constituents of <I>D. erythrosora</I> have been conducted so far.</P><P><B>Objective:</B></P><P>In this study, we investigated the phytochemical constituents of <I>D. erythrosora</I>.</P><P><B>Materials and Methods:</B></P><P>The 80% methanol extract of the aerial part of <I>D. erythrosora</I> was used for the isolation of phenolic compounds. The isolated compounds were elucidated by various spectroscopic methods including nuclear magnetic resonance and mass spectrometry.</P><P><B>Results:</B></P><P>The present phytochemical investigation on the aerial part of <I>D. erythrosora</I> led to the isolation of two new phenolic glycosides, 1 and 2, as well as nine known flavonoids including two flavones (3 and 4) and seven flavonols (5-11).</P><P><B>Conclusion:</B></P><P>In this study, two new phenolic glycosides together with nine known flavonoids were isolated from the aerial part of <I>D. erythrosora</I>. Among them, compounds 4, 8, and 11 were isolated for the first time in <I>Dryopteridaceae</I> family from the present investigation. These results helped us to enrich our understanding of the chemical constituents of <I>D. erythrosora</I> and to identify compounds 1 and 2 which could be potential chemotaxonomic markers for the species.</P><P><B>SUMMARY</B></P><P><P>The genus <I>Dryopteris</I> has been used as traditional medicine, especially to treat hepatitis and protect liver</P><P>Two new phenolic glycosides were isolated from <I>D. erythrosora</I></P><P>Nine known flavonoids (3-11) were isolated from <I>D. erythrosora</I></P><P>Compounds 4, 8, and 11 were isolated for the first time in <I>Dryopteridaceae</I> family.</P></P><P>[GRAPHIC OMISSION]</P><P><B>Abbreviations used:</B> HPLC: High-performance liquid chromatography; Q-TOF LC/MS: Quadrupole-time-of-flight liquid chromatography/mass spectrometry; NMR: Nuclear magnetic resonance; TMS: Tetramethylsilane</P>
Heejung Yang,Jeom Yong Kim,Sun Ok Kim,Young Hyo Yoo,Sang Hyun Sung 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: Ginsenosides, the major ingredients of Panax ginseng, have been studied for many decades in Asian countries as a result of their wide range of pharmacological properties. The less polar ginsenosides, with one or two sugar residues, are not present in nature and are produced during manufacturing processes by methods such as heating, steaming, acid hydrolysis, and enzyme reactions. ¹H-NMR and <SUP>13</SUP>C-NMR spectroscopic data for the identification of the less polar ginsenosides are often unavailable or incomplete. Methods: We isolated 21 compounds, including 10 pairs of 20(S) and 20(R) less polar ginsenosides (1-20), and an oleanane-type triterpene (21) from a processed ginseng preparation and obtained complete ¹H-NMR and <SUP>13</SUP>C-NMR spectroscopic data for the following compounds, referred to as compounds 1-21 for rapid identification: 20(S)-ginsenosides Rh2 (1), 20(R)-Rh2 (2), 20(S)-Rg3 (3), 20(R)-Rg3 (4), 6´-O-acetyl-20(S)-Rh2 [20(S)-AcetylRh2] (5), 20(R)-AcetylRh2 (6), 25-hydroxy-20(S)-Rh2 (7), 25-hydroxy-20(S)-Rh2 (8), 20(S)-Rh1 (9), 20(R)-Rh1 (10), 20(S)-Rg2 (11), 20(R)-Rg2 (12), 25-hydroxy-20(S)-Rh1 (13), 25-hydroxy-20(R)-Rh1 (14), 20(S)-AcetylRg2 (15), 20(R)-AcetylRg2 (16), Rh4 (17), Rg5 (18), Rk1 (19), 25-hydroxy-Rh4 (20), and oleanolic acid 28-O-β-D-glucopyranoside (21).