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Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice
Jung, Hwajin,Park, Haram,Choi, Yeonsoo,Kang, Hyojin,Lee, Eunee,Kweon, Hanseul,Roh, Junyeop Daniel,Ellegood, Jacob,Choi, Woochul,Kang, Jaeseung,Rhim, Issac,Choi, Su-Yeon,Bae, Mihyun,Kim, Sun-Gyun,Lee, NATURE AMERICA 2018 NATURE NEUROSCIENCE Vol.21 No.9
Choi, Jin H.,Kim, Hanseul,Lim, Ji-Hun,Kwon, Soon-Jong,Park, Eun Young,Lee, Kyu Tae The Electrochemical Society 2018 Journal of the Electrochemical Society Vol.165 No.16
<P>Ni-rich layered oxide cathode materials have been extensively investigated as a cathode material for lithium-ion batteries because of their higher reversible capacity and lower cost than lithium cobalt oxide. However, most of them have been examined using lab-scale coin cells, and consequently, there is a limit to fully understanding the failure mode of Ni-rich layered oxides in commercial high energy Li-ion batteries. In this paper, the pouch-type 20 Ah-scale Li-ion full cells are fabricated using Ni-rich layered oxides as a cathode and graphite as an anode. Then, the electrochemical performances and thermal behaviors of Ni-rich layered oxides are compared to investigate their failure mode in large-scale Li-ion cells. The cell skin temperature is measured to observe the thermal behavior of Ni-rich layered oxides. A strong correlation between capacity retention, cell temperature variation, and internal cell impedance is observed in Ni-rich layered oxides. Moreover, an increase in the internal cell impedance during cycling is attributed to interfacial degradation of Ni-rich layered oxides rather than their bulk structural deformation. Therefore, we need to focus on the interfacial stability of Ni-rich layered oxide materials to improve their electrochemical performance for large-scale Li-ion batteries.</P>
Kim, Hanseul,Choi, Aram,Doo, Sung Wook,Lim, Jungwoo,Kim, YoungJin,Lee, Kyu Tae The Electrochemical Society 2018 Journal of the Electrochemical Society Vol.165 No.2
<P>LiNiO2 is a promising cathode material for lithium ion batteries because of its high specific capacity (approximately 220 mA h g(-1)). However, there are several challenging issues in the development of LiNiO2, including its poor cycle and rate performance because of its structural deterioration due to thermodynamically unstable Ni3+. This paper demonstrates the role of Na+ in the electrochemical performance and structural stability of [Li1-xNax]NiO2 (x = 0, 0.005, 0.01, 0.025, and 0.05). Charge disproportionation Ni3+. Ni2+ and Ni4+ in LiNiO2 increases the cation mixing of Li+ and Ni2+ during cycling, resulting in the poor cycle performance of LiNiO2. However, Na+ in [Li1-xNax]NiO2 mitigates the charge disproportionation because of the larger size of Na+ than Li+, leading to the improved structural stability of [Li1-xNax]NiO2. Consequently, Na+-doped LiNiO2 alleviates the increase in the cation mixing of Li+ and Ni2+ during cycling compared to bare LiNiO2. This results in the improved cycle performance of [Li1-xNax]NiO2 (x = 0.05), such as approximately 76% of capacity retention after 100 cycles. Moreover, the substitution of Li+ with Na+ in LiNiO2 improves the storage characteristics of [Li1-xNax]NiO2, leading to a negligible capacity loss even after long-term storage. (c) 2018 The Electrochemical Society.</P>
Park, Hanseul,Hwang, Jee-hyun,Han, Ji-Seok,Lee, Byoung-Seok,Kim, Yong-Bum,Joo, Kyung-Mi,Choi, Min-Seok,Cho, Sun-A.,Kim, Bae-Hwan,Lim, Kyung-Min Elsevier 2018 Food and chemical toxicology Vol.121 No.-
<P><B>Abstract</B></P> <P>Permanent oxidative hair dyes are widely used but their toxicity is not well-established. Here we aimed to evaluate the skin sensitization and irritation of nine hair dye substances (MAP, MRP-N, RS, PAOX, 2,4-DAPE, 2,6-PYR, PPD, Grey HED and PM) permitted for use in EU and Korea, using <I>in vitro</I> and <I>in chemico</I> and <I>in silico</I> test methods. Skin sensitization was evaluated by the KeratinoSens™ assay, Direct Peptide Reactivity Assay (DPRA) and DEREK. Six of nine dyes tested were determined as sensitizers in common. However, the decision for MAP, RS or PAOX was diverged across assays showing 2 positives and 1 negative. Skin irritation of hair dye substances was assessed with or without 6% H<SUB>2</SUB>O<SUB>2</SUB> on a reconstructed human epidermis, Epiderm™, which demonstrated that H<SUB>2</SUB>O<SUB>2</SUB> increased the skin irritation potential of some hair dyes. PPD and PM were determined to be irritants with H<SUB>2</SUB>O<SUB>2</SUB>. Epidermal damages by hair dye and H<SUB>2</SUB>O<SUB>2</SUB> could be further confirmed through the histology of tissue remaining after MTT assay. Collectively, our study demonstrated that hair dyes possess potential skin sensitization and irritation issues which could be further aggravated by H<SUB>2</SUB>O<SUB>2</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 9 hair dyes were evaluated for skin sensitization and irritation using <I>in vitro</I>, <I>in silico</I> and in chemico tests. </LI> <LI> Skin sensitization prediction was diverged across test methods for 3 dyes with pre- or pro-haptenic natures. </LI> <LI> Inclusion of H<SUB>2</SUB>O<SUB>2</SUB> increased the skin irritation of hair dyes in Epiderm™ SIT, which was confirmed by histology. </LI> </UL> </P>