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한국과 일본 대학생의 스포츠상황에 대한 도덕적 가치판단수준 비교
함정혜(Chung Hae Hahm) 한국여성체육학회 2013 한국여성체육학회지 Vol.27 No.1
The purpose of this study was to compare the differences of moral reasoning among general students, sports related majors students, and student athletes in Korea and Japan University. We collected total 612 out of 700 (315 from Korea, 297 from Japan) and 88 questionnaires were excluded questionnaire due to incompleteness and unreliable data. For this study, Hahm-Bellar Values Choice Inventory-16(HBVCI-16), which is a Moral Reasoning Questionnaire on Sports Activities, was used. The collected data was analyzed by t-test, one way ANOVA and two way ANOVA with using SPSS Var. 17.0 statistical package program and result were as follow. First, the Japan student`s overall score of moral reasoning were lower compare to Korean university students. Second, there were 1 % higher score of moral reasoning in woman against man and in younger subjects. Sports majored university students presented 1% higher score against other related students and higher grade students presented 5% higher score against lower grade students. Third, among student athletes of Korea and Japan, although there were no significant differences, it was 0.1% higher among those who engaged in individual sports and 5% higher score in those who have less sports career.
A Model for Computer-Aided Process Planning System in Flexible Manufacturing Systems
Kang, Young-Sig,Hahm, Hyo-Joon,Rim, Suk-Chul,Kim, Seung-Baum The Korean Society for Quality Management 1994 품질경영학회지 Vol.22 No.1
Most of computer-aided process planning(CAPP) systems have been developed to automate the process planning function. In this paper, we describe an analytical model for a CAPP system in order to improve the performance of production system in flexible manufacturing systems(FMSs) for computer intergrated manufacturing(CIM) architecture. This paper proposes an optimal process planning that minimizes the load time by minimizing the cycle time and the number of workstations using Kang and Hahm's heuristic approach so as to improve the performance of production system under the batch production of discrete products. We also perform simulation using SIMAN language to campare the line utilization of each for various product types. The proposed algorithm can be implemented in existing FMSs for on-line control of product quantity using programmable logic controllers(PLC) and communication devices.
Hahm, Young Hye,Hahm, Sung Ho,Jo, Hyoun Young,Ahn, Yeong Hee Hindawi 2018 International journal of analytical chemistry Vol.2018 No.-
<P>Glycosylation is one of the most important posttranslational modifications for proteins, including therapeutic antibodies, and greatly influences protein physiochemical properties. In this study, glycopeptide mapping of a reference and biosimilar recombinant antibodies (rAbs) was performed using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and an automated Glycoproteome Analyzer (GPA) algorithm. The tandem mass analyses for the reference and biosimilar samples indicate that this approach proves to be highly efficient in reproducing consistent analytical results and discovering the implications of different rAb production methods on glycosylation patterns. Furthermore, the comparative analysis of a mutagenized rAb glycoprotein proved that a single amino acid mutation in the Fc portion of the antibody molecule caused increased variations in glycosylation patterns. These variations were also detected by the mass spectrometry method efficiently. This mapping method, focusing on precise glycopeptide identification and comparison for the identified glycoforms, can be useful in differentiating aberrant glycosylation in biosimilar rAb products.</P>
HAHM, MOON SUN,CHUNG, BONG HYUN 한국미생물 · 생명공학회 2001 Journal of microbiology and biotechnology Vol.11 No.5
The gene encoding yeast pro-carboxypeptidase Y (pro-CPY) has been cloned and expressed in Escherichia coli. Most of the expressed pro-CPY was accumulated as cytoplasmic insoluble aggregates. In our previous study [3], active CPY was obtained by renaturation of entirely denatured pro-CPY followed by in vitro proteolytic processing with proteinase K along with the activation process. The same refolding process was performed to produce an active CPY from pro-CPY inclusion bodies with renaturation buffers containing proteinase K at different concentrations. The refolding efficiency decreased from 25% to 2% in the renaturation buffers containing proteinase K at concentrations of 60㎍/ml and 0.6㎍/ml, respectively. In an attempt to increase the refolding efficiency with a lesser amount of proteinase K, a novel fed-batch refolding process was developed. In a fed-batch refolding, 99 ml of the renaturation buffer containing pro-CPY was gradually added into I ml of the renaturation buffer containing 60 ㎍/ml of proteinase K to give a final proteinase K concentration of 0.6 ㎍/ml. The fed-batch refolding process resulted in a refolding efficiency of 18%, which corresponded to a 9-fold increase over that (2%) in the batch process.
Hahm, Ki-Baik,Song, Young-Joon,Oh, Tae-Young,Lee, Jeong-Sang,Surh, Young-Joon,Kim, Young-Bae,Yoo, Byung-Moo,Kim, Jin-Hong,Ha, Sang-Uk,Nahm, Ki-Taik,Kim, Myung-Wook,Kim, Dae-Yong,Cho, Sung-Won Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.1
Although debates still exist whether Helicobacter pylori infection is really class I carcinogen or not, H. pylori has been known to provoke precancerous lesions like gastric adenoma and chronic atrophic gastritis with intestinal metaplasia as well as gastric cancer. Chronic persistent, uncontrolled gastric inflammations are possible basis for ensuing gastric carcinogenesis and H. pylori infection increased COX-2 expressions, which might be the one of the mechanisms leading to gastric cancer. To know the implication of long-term treatment of antiinflammatory drugs, rebamipide or nimesulide, on H. pylori-associated gastric carcinogenesis, we infected C57BL/6 mice with H. pylori, especially after MNU administration to promote carcinogenesis and the effects of the long-term administration of rebamipide or nimesulide were evaluated. C57BL/6 mice were sacrificed 50 weeks after H. pylori infection. Colonization rates of H. pylori, degree of gastric inflammation and other pathological changes including atrophic gastritis and metaplasia, serum levels and mRNA transcripts of various mouse cytokines and chemokines, and NF-${\kappa}B$ binding activities, and finally the presence of gastric adenocarcinoma were compared between H. pylori infected group (HP), and H. pylori infected group administered with long-term rebamipide containing pellet diets (HPR) or nimesulide mixed pellets (HPN). Gastric mucosal expressions of ICAM-1, HCAM, MMP, and transcriptional regulations of NF-${\kappa}B$ binding were all significantly decreased in HPR group than in HP group. Multi-probe RNase protection assay showed the significantly decreased mRNA levels of apoptosis related genes and various cytokines genes like IFN-$\gamma$, RANTES, TNF-$\alpha$, TNFR p75, IL-$1{\beta}$ in HPR group. In the experiment designed to provoke gastric cancer through MNU treatment with H. pylori infection, the incidence of gastric carcinoma was not changed between HP and HPR group, but significantly decreased in HPN group, suggesting the chemoprevention of H. pylori-associated gastric carcinogenesis by COX-2 inhibition. Long-term administration of antiinflammatory drugs should be considered in the treatment of H. pylori since they showed the molecular and biologic advantages with possible chemopreventive effect against H. pylori-associated gastric carcinogenesis. If the final concrete proof showing the causal relationship between H. pylori infection and gastric carcinogenesis could be obtained, that will shed new light on chemoprevention of gastric cancer, that is, that gastric/cancer could be prevented through either the eradication of H. pylori or lessening the inflammation provoked by H. pylori infection in high risk group.
Hahm, Dae Hyun,Yeom, Mi Jung,Ko, Whae Min,Lee, Eunjoo H.,Lee, Hye Jung,Shim, In Sop,Kim, Hong Yeoul 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.1
A 1,989-bp genomic region encoding nickel resistance genes was isolated from Legionella pneumophila, a pathogen for legionellosis. From a sequencing and computer analysis, the region was found to harbor two structural genes, a nreB-like protein gene (1,149 bp) and a nreA-like protein gene (270 bp), in a row. Both genes exhibited a significant degree of similarity to the corresponding genes from Synechocystis sp. PCC6803 (54% amino acid sequence identity) and Achromobacter xylosoxidans 31A (76%). The gene was successfully expressed in E. coli MG1655 and conferred a nickel resistance of up to 5mM in an LB medium and 3 mM in a TMS medium including gluconate as the sole carbon source. E. coli harboring the nickel resistance gene also exhibited a substantial resistance to cobalt, yet no resistance to cadmium or zinc. Since the extracellular concentration of nickel remained constant during the whole period of cultivation, it was confirmed that the nickel resistance was provided by an efflux system like the Ni^2+ permease (nrsD) of Synechocystis sp. strain PCC6803. Since polyphosphate (poly-P) is known as a global regulator for gene expression as well as a potential virulence factor in E. coli, the nickel resistance of a ppk mutant of E. coli MG1655 harboring the nickel resistance gene from L. pneumophila was compared with that of its parental strain. The nickel resistance was significantly attenuated by ppk inactivation, which was more pronounced in an LB medium than in a TMS medium.
THE INSTITUTIONAL DEVELOPMENT OF BLUE HOUSE IN THE PARK CHUNG HEE PRESIDENCY
Hahm, Sung Deuk 경남대학교 극동문제연구소 2002 ASIAN PERSPECTIVE Vol.26 No.2
The presidential staff system in Korea is now a well-developed and necessary resource for the occupant of the Office of the President, which has become known as Blue House, and it is difficult to imagine how presidents could have responded to the pressures and demands without such staff assistance. But it is also true that the development of the presidential staff system has become problematic and the size of the staff is only one part of that problem. This article examines the structure of Blue House, focusing on its organizational changes. The modern presidential staff system in Korea evolved greatly during the Park Chung Hee presidency. His era marked the transformation of the presidency from a small, personalized office to a collection of specialized bureaucracies with hundreds of professional staffers.