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Heajin Park,Hye Seong Hwang,Jihye Kim,Haesung Kim,Hyun Il Oh,Jai Yeon Choi,Hahn-Sun Jung,Song-Jae Lee,Sang-Min Lim,Dong-Il Kim,Dae Kyong Kim,Ha Hyung Kim 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.01
Human cytotoxic T-lymphocyte antigen 4-immunoglobulin (hCTLA4Ig) is an immunosuppressive therapeutic, and recently produced rice cell-derived hCTLA4Ig (hCTLA4IgP)reportedly exhibits in vitro immunosuppressive activities equivalent to those of Chinese hamster ovary cell-derived hCTLA4Ig (hCTLA4IgM). However, limitations of hCTLA4IgP include shortened in vivo half-life as well as the presence of nonhuman N-glycans containing b1,2-xylose and a1,3-fucose, which cause immunogenic reactions in humans. In the present study, human β1,4-galactose-extended hCTLA4IgP (hCTLA4IgP-Gal)was expressed through the coexpression of human β 1,4-galactosyltransferase (hGalT)and hCTLA4Ig in an attempt to overcome these unfavorable effects. The results indicated that both encoding hGalT and hCTLA4Ig were successfully coexpressed, and the analysis of N-glycan and its relative abundance in purified hCTLA4IgP-Galindicated that not only were the two glycans containing β1,4-galactose newly extended, but also glycans containing both b1,2-xylose and a1,3-fucose were markedly reduced and high-mannose-type glycans were increased compared to those of hCTLA4IgP,respectively. Unlike hCTLA4IgP, hCTLA4IgP-Gal was effective as an acceptor via β1,4-galactose for in vitro sialylation. Additionally, the serum half-life of intravenously injected hCTLA4IgP-Gal in Sprague-Dawley rats was 1.9 times longer than that of hCTLA4IgP, and the clearance pattern of hCTLA4IgP-Gal was close to that for hCTLA4IgM.These results indicate that the coexpression with hGalT and hCTLA4IgP is useful for both reducing glycan immunogens and increasing in vivo stability. This is the first report of hCTLA4Ig as an effective therapeutics candidate in glycoengineered rice cells.
Feasibility of Spin-Echo Echo-Planar Imaging MR Elastography in Livers of Children and Young Adults
Kim, Jin Kyem,Yoon, Haesung,Lee, Mi-Jung,Kim, Myung-Joon,Han, Kyunghwa,Koh, Hong,Kim, Seung,Han, Seok Joo,Shin, Hyun Joo Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.3
Purpose: To assess the feasibility of the use of spin-echo echo-planar imaging (SE-EPI) magnetic resonance elastography (MRE) in livers of children and young adults. Materials and Methods: Patients (${\leq}20$ years old) who underwent 3T SE-EPI MRE were included retrospectively. Subjects were divided into three groups according to the purpose of the liver MRI: suspicion of fatty liver or focal fat deposition in the liver (FAT group), liver fibrosis after receiving a Kasai operation from biliary atresia (BA group), and hepatic iron deposition after receiving chemotherapy or transfusions (IRON group). Technical failure of MRE was defined when a stiffness map showed no pixel value with a confidence index higher than 95%, and the patients were divided as success and failure groups accordingly. Clinical findings including age, gender, weight, height, and body mass index and magnetic resonance imaging results including proton density fat fraction (PDFF), $T2^*$, and MRE values were assessed. Factors affecting failure of MRE were evaluated and the image quality in wave propagation image and stiffness map was evaluated using the appropriate scores. Results: Among total 240 patients (median 15 years, 211 patients in the FAT, 21 patients in the BA, and 8 patients in the IRON groups), technical failure was noted in six patients in the IRON group (6/8 patients, 75%), while there were no failures noted in the FAT and BA groups. These six patients had $T2^*$ values ranging from 0.9 to 3.8 ms. The image quality scores were not significantly different between the FAT and BA groups (P > 0.999), while the scores were significantly lower in the IRON group (P < 0.001). Conclusion: The 3T SE-EPI MRE in children and young adults had a high technical success rate. The technical failure was occurred in children with decreased $T2^*$ value (${\leq}3.8ms$) from iron deposition.
Kim Jisoo,Shin Hyun Joo,Yoon Haesung,Han Seok Joo,Koh Hong,Kim Myung-Joon,Lee Mi-Jung 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.2
Objective: To determine whether the values of hepatic apparent diffusion coefficient (ADC) can differentiate biliary atresia (BA) from non-BA or be correlated with the grade of hepatic fibrosis in infants with cholestasis. Materials and Methods: This retrospective cohort study included infants who received liver MRI examinations to evaluate cholestasis from July 2009 to October 2017. Liver ADC, ADC ratio of liver/spleen, aspartate aminotransferase to platelet ratio index (APRI), and spleen size were compared between the BA and non-BA groups. The diagnostic performances of all parameters for significant fibrosis (F3–4) were obtained by receiver-operating characteristics (ROCs) curve analysis. Results: Altogether, 227 infants (98 males and 129 females, mean age = 57.2 ± 36.3 days) including 125 BA patients were analyzed. The absolute ADC difference between two reviewers was 0.10 mm2/s for both liver and spleen. Liver ADC value was specific (80.4%) and ADC ratio was sensitive (88.0%) for the diagnosis of BA with comparable performance. There were 33 patients with F0, 15 with F1, 71 with F2, 35 with F3, and 11 with F4. All four parameters of APRI (τ = 0.296), spleen size (τ = 0.312), liver ADC (τ = -0.206), and ADC ratio (τ = -0.288) showed significant correlation with fibrosis grade (all, p < 0.001). The cutoff values for significant fibrosis (F3–4) were 0.783 for APRI (area under the ROC curve [AUC], 0.721), 5.9 cm for spleen size (AUC, 0.719), 1.044 x 10-3 mm2/s for liver ADC (AUC, 0.673), and 1.22 for ADC ratio (AUC, 0.651). Conclusion: Liver ADC values and ADC ratio of liver/spleen showed limited additional diagnostic performance for differentiating BA from non-BA and predicting significant hepatic fibrosis in infants with cholestasis.
Decrease of Muscle Mass in Young Patients With Neuromuscular Disease: Assessment of Sarcopenia
Kim Jisoo,Yoon Haesung,Lim Hyun Ji,Kim Hyun Woo,Suk Yong June,Park Kun-Bo,Lee Mi-Jung 대한의학회 2023 Journal of Korean medical science Vol.38 No.21
Background: Sarcopenia can be associated with the disease etiologies other than degenerative processes, such as neurologic disease including cerebral palsy, myelomeningocele, or Duchenne muscular dystrophy, even in children. Although the relationship between neurologic disease and scoliosis or ambulatory function is known, the mediators affecting scoliosis or gait function in these patients are unclear, an example might be sarcopenia. This study aimed to assess the degree of sarcopenia in young patients with neurologic diseases using computed tomography (CT), and analyze the correlation between sarcopenia and scoliosis or ambulatory function. Methods: Pediatric and young adult patients (≤ 25 years old) who underwent whole-spine or lower-extremity CT were retrospectively included. From bilateral psoas muscle areas (PMAs) at the L3 level, the psoas muscle z-score (PMz) and psoas muscle index [PMI = PMA/(L3 height)2 ] were calculated. The t-test, Fisher’s exact test, and logistic regression analyses were performed. Results: A total of 121 patients (56 men, mean age 12.2 ± 3.7 years) were included with 79 neurologic and 42 non-neurologic diseases. Patients with neurologic diseases had lower PMz (P = 0.013) and PMI (P = 0.026) than patients without. In neurologic disease patients, severe scoliosis patients showed lower PMz (P < 0.001) and PMI (P = 0.001). Non-ambulatory patients (n = 42) showed lower BMI (β = 0.727, P < 0.001) and PMz (β = 0.547, P = 0.025). In non-ambulatory patients, patients with severe scoliosis also showed lower PMz (P < 0.001) and PMI (P = 0.004). Conclusion: Patients with neurologic diseases could have sarcopenia even in young age. Psoas muscle volume was also associated with ambulatory function in these patients. Sarcopenia was more severe in severe scoliosis patients in the non-ambulatory subgroup.
Kim Jisoo,Albakheet Salman S.,Han Kyung Hwa,Yoon Haesung,Lee Mi-Jung,Koh Hong,Kim Seung,Suh Junghwan,Han Seok Joo,Ihn Kyong,Shin Hyun Joo 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.11
Objective: To assess the feasibility of quantitatively assessing pancreatic steatosis using magnetic resonance imaging (MRI) and its correlation with obesity and metabolic risk factors in pediatric patients. Materials and Methods: Pediatric patients (≤ 18 years) who underwent liver fat quantification MRI between January 2016 and June 2019 were retrospectively included and divided into the obesity and control groups. Pancreatic proton density fat fraction (P-PDFF) was measured as the average value for three circular regions of interest (ROIs) drawn in the pancreatic head, body, and tail. Age, weight, laboratory results, and mean liver MRI values including liver PDFF (L-PDFF), stiffness on MR elastography, and T2* values were assessed for their correlation with P-PDFF using linear regression analysis. The associations between P-PDFF and metabolic risk factors, including obesity, hypertension, diabetes mellitus (DM), and dyslipidemia, were assessed using logistic regression analysis. Results: A total of 172 patients (male:female = 125:47; mean ± standard deviation [SD], 13.2 ± 3.1 years) were included. The mean P-PDFF was significantly higher in the obesity group than in the control group (mean ± SD, 4.2 ± 2.5% vs. 3.4 ± 2.4%; p = 0.037). L-PDFF and liver stiffness values showed no significant correlation with P-PDFF (p = 0.235 and p = 0.567, respectively). P-PDFF was significantly associated with obesity (odds ratio 1.146, 95% confidence interval 1.006–1.307, p = 0.041), but there was no significant association with hypertension, DM, and dyslipidemia. Conclusion: MRI can be used to quantitatively measure pancreatic steatosis in children. P-PDFF is significantly associated with obesity in pediatric patients.
Robust optical measurement of water vapor in steel-making process
Haesung Park,Youngjean Jung,Kyoungsik Kim,Jinsu Bae,Jonghak Lee,Kyoungsik Kim 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
Based on tunable diode laser spectroscopy (TDLS), we develop a simple and efficient humidity monitoring scheme to improve reliability of measurement under randomly changing transmission condition. This measurement scheme can detect the humidity of a monitored system in either high or low scattering condition such as powder coal fired furnace in steel-making process. Distributed feed-back (DFB) diode laser is used to evaluate the relative and absolute humidity by making direct absorption measurement near 938nm region where 2ν1 + ν3 water vapor transition band exists. This system gives reliable measurement results under either high or low scattering condition.
안해성(Haesung Ahn),차은영(Eunyoung Cha),이종현(Jonghyun Lee),장주환(Juhwan Jang),김형석(Hyeongseok Kim),김정창(Jeongchang Kim) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
본 논문에서는 해양도시 영도 맞춤형 스마트타운 구축사업 추진방안을 제시한다. 영도구의 지역특성 및 현황을 바탕으로 SWOT 분석을 통해 스마트타운 구축의 적합성을 판단한다. 또한, 영도구 5 대 전략과제별 추진 계획 중 스마트타운 구축의 기반을 마련할 수 있는 항목을 분석하고 스마트타운 구축을 위한 진단을 내린다. 영도구의 스마트타운 구축을 위한 추진방안은 영도구청 관계자와 여러 차례 회의를 통해 의견을 수렴하고 방향성을 도출하였다. 도출된 결과로서 영도구의 주차 개선방안과 전통시장의 현대화를 위한 방안을 제시한다.