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      • SCIESCOPUSKCI등재

        Carrier Tracking Loop using the Adaptive Two-Stage Kalman Filter for High Dynamic Situations

        Kwang-Hoon Kim,Gyu-In Jee,Jong-Hwa Song 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.6

        In high dynamic situations, the GPS carrier tracking loop requires a wide bandwidth to track a carrier signal because the Doppler frequency changes more rapidly with time. However, a wide bandwidth allows noises within the bandwidth of the tracking loop to pass through the loop filter. As these noises are used in the numerical controlled oscillator (NCO), the carrier tracking loop of a GPS receiver shows a degraded performance in' high dynamic situations. To solve this problem, an adaptive two-stage Kalman filter, which offers the NCO a less noisy phase error, can be used. This filter is based on a carrier phase dynamic model and can adapt to an incomplete dynamic model and a quickly changed Doppler frequency. The performance of the proposed tracking loop is verified by several simulations.

      • 차량관제시스템을 위한 Inverted DGPS 시스템

        한승재,홍진석,지규인 건국대학교 1997 學術誌 Vol.41 No.2

        Vehicle Monitoring System which can efficiently control and manage the resources like vehicles, cargos and services is required in many transportation related areas like ITS /IVHS. GPS or DGPS is widely used in determining the vehicle location in service. DGPS can glove more accurate position than GPS, but it needs an additional wireless communication link for DGPS correction reception from the DGPS reference station. But, in some applications lire tall or truck monitoring system, the user doesn't need to know the his accurate position. The DGPS correction can be performed in the monitoring station based on the informations from the GPS receiver in the user vehicle and then the monitor station can locate vehicle position accurately like conventional DGPS. For this case an additional communication link for DGPS RTCM is not necessary. This method is called inverted DGPS. In this paper we develop an IDGPS system algorithm and implement it using wireless data modem network and digital map. Test results show its effectiveness. Key Words : GPS, DGPS, Inverted DGPS, vehicle Monitoring System, RTCM

      • 멀티플렉스방식의 측정장치가 있는 시스템의 예측제어

        지규인 건국대학교 1995 學術誌 Vol.39 No.2

        This paper considers the design of predictive control systems characterized by multiplexed measurement and multirate sampling mechanism. Plants outputs are measured In various sampling rates through a multiplexed measurement system where a single common instrument is shared by several controllers. For each controler the output measurements are only available at infrequent rate less than the rate adopted for input sampling. To resolve the problem of infrequent output measurements, intermediate control inputs between actual output samplings are calculated based on the output prediction. A dynamic polling method for multiplexing is proposed and shows an improved control performance.

      • F-9 : Free Paper Presentation ; Association between the Interleukin-27 Polymorphisms and Pulmonary Tuberculosis in a Korean Population

        ( Jee Youn Oh ),( Jae Kyeom Sim ),( Jong Hyun Choi ),( Sue In Choi ),( Ji Young Park ),( Kyung Hoon Min ),( Eun Joo Lee ),( Young Hur Gyu ),( Sung Yong Lee ),( Sang Yeub Lee ),( Je Hyeoung Kim ),( Cho 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

        Objectives: We investigated the correlation between IL-27 polymorphisms in the promoter region of -964A/G and the exon region of 2095T/G, 4603G/A, and 4730T/C and the development of pulmonary TB, and its radiographic characteristics and severity. Methods: Differences in the allele and genotype distributions of the -964A/G, 2095T/G, 4603G/A, and 4730T/C polymorphisms were analyzed between 224 pulmonary TB patients and 233 healthy controls. Subgroup analysis was done between patients with single- and multi-lobar involvement, and between patients with and without cavitation. Serum IL-27 concentration was measured using an enzyme-linked immunosorbent assay. Results: There were no significant differences in the allele or genotype distributions between patients with pulmonary TB and healthy controls. However, in patients with single-lobar involvement, the -964A/A genotype was more prevalent than the -964 A/G or -964 G/G genotype in patients with multi-lobar involvement (50.0% vs. 31.3%, P=0.01, OR 2.19, 95% CI 1.17∼4.12). There was no difference between patients with and without cavitation (P>0.05). Serum median IL-27 concentration was significantly higher in patients with single-lobar involvement than those with multi-lobar involvement (P=0.03) and with -964A/A genotypes than -964A/G or -964G/G genotypes (P=0.02). Conclusions: The genetic polymorphisms of IL-27 are not associated with the development of TB. However, the -964A/G genetic polymorphism of IL-27 and serum IL-27 concentrations are associated with the severity of pulmonary TB by radiographic characteristics.Objectives: We investigated the correlation between IL-27 polymorphisms in the promoter region of -964A/G and the exon region of 2095T/G, 4603G/A, and 4730T/C and the development of pulmonary TB, and its radiographic characteristics and severity. Methods: Differences in the allele and genotype distributions of the -964A/G, 2095T/G, 4603G/A, and 4730T/C polymorphisms were analyzed between 224 pulmonary TB patients and 233 healthy controls. Subgroup analysis was done between patients with single- and multi-lobar involvement, and between patients with and without cavitation. Serum IL-27 concentration was measured using an enzyme-linked immunosorbent assay. Results: There were no significant differences in the allele or genotype distributions between patients with pulmonary TB and healthy controls. However, in patients with single-lobar involvement, the -964A/A genotype was more prevalent than the -964 A/G or -964 G/G genotype in patients with multi-lobar involvement (50.0% vs. 31.3%, P=0.01, OR 2.19, 95% CI 1.17∼4.12). There was no difference between patients with and without cavitation (P>0.05). Serum median IL-27 concentration was significantly higher in patients with single-lobar involvement than those with multi-lobar involvement (P=0.03) and with -964A/A genotypes than -964A/G or -964G/G genotypes (P=0.02). Conclusions: The genetic polymorphisms of IL-27 are not associated with the development of TB. However, the -964A/G genetic polymorphism of IL-27 and serum IL-27 concentrations are associated with the severity of pulmonary TB by radiographic characteristics.

      • SCIESCOPUSKCI등재

        Stimulatory Effects of Ginsenosides on Bovine Brain Glutamate Decarboxylase

        Baek, Nam In,Choi, Soo Young,Park, Jin Kyu,Cho, Sung Woo,Hong, Joung Woo,Ahn, Jee Yin,Bahn, Jae Hoon,Jeon, Seong Gyu,Chung, Young Mee,Hwang, Eun Joo 생화학분자생물학회 1999 BMB Reports Vol.31 No.3

        A GABA synthesizing enzyme, glutamate decarboxylase, has been purified from bovine brain by several chromatographic procedures. The preparation appeared homogeneous on SDS-PAGE. The enzyme is a homodimeric protein with a molecular mass of 120 kDa. The activation of glutamate decarboxylase by ginesenosides from Panax ginseng C.A. Meyer has been studied. Preincubation of the enzyme with total ginsenoside, Rb₂ and Rc ginsenosides, increased glutamate decarboxylase activities in a dose-dependent manner. There was a reproducible decrease in K_m, in addition to a increase in V_(max), in response to increasing concentrations of the Rc ginsenoside fraction. Upon addition of the ginsenoside to the enzyme, a decrease in flurorescence intensity was discernible, together with an increase in emission anisotropy. Judging from the anisotropy values, the ginsenoside is rapidly trapped by the protein matrix. Total ginsenoside was administered to rats and the rat brains were removed for the measurement of the changes of GABA shunt regulating enzyme activities. Among the GABA shunt regulating enzymes, only the glutamate decarboxylase activities were increased after ginsenoside treatment. Therefore, it is suggested that the ginsenosides may elevate the GABA level in brain by activation of glutamate decarboxylase and the enzymatic activation might be due to the conformational change induced by binding of ginsenoside to the enzyme.

      • KCI등재

        도심에서 수직구조물 랜드마크를 이용한 3D LIDAR 기반 차량정밀측위

        임준혁(Jun-Hyuck Im),임성혁(Sung-Hyuck Im),송종화(Jong-Hwa Song),지규인(Gyu-In Jee) 제어로봇시스템학회 2017 제어·로봇·시스템학회 논문지 Vol.23 No.12

        Tall buildings in urban areas obstruct the GPS satellite signal reception, thus the GPS position accuracy can be very poor. However, buildings in urban areas can be used to generate a landmark map for precise vehicle localization. This map’s information can be represented in various forms. We focused on the outer wall of a building that was erected vertically from the ground and almost flat. Therefore, vertical corners that meet the vertical planes are present everywhere in urban areas. These corners can provide very good landmarks and can be extracted using LIDAR. Additionally, traffic signs can be used for localization. The traffic signs are present in the road and reflect light well. Therefore, traffic signs can be clearly distinguished from other structures using LIDAR reflectivity. In this paper, we used building’s vertical corner and traffic signs for vehicle localization in an urban area. In addition, we proposed a vertical structure map with information for vertical corners and traffic signs. The experiment was carried out in the Gangnam area of Seoul, South Korea. The traveling distance was approximately 4.5 km and the maximum traveling speed was approximately 80 km/h. The lateral and longitudinal RMS position errors were 0.118 m and 0.231 m, respectively.

      • KCI등재

        Precise Vehicle Localization Using 3D LIDAR and GPS/DR in Urban Environment

        Im, Jun-Hyuck,Jee, Gyu-In The Institute of Positioning 2017 Journal of Positioning, Navigation, and Timing Vol.6 No.1

        GPS provides the positioning solution in most areas of the world. However, the position error largely occurs in the urban area due to signal attenuation, signal blockage, and multipath. Although many studies have been carried out to solve this problem, a definite solution has not yet been proposed. Therefore, research is being conducted to solve the vehicle localization problem in the urban environment by converging sensors such as cameras and Light Detection and Ranging (LIDAR). In this paper, the precise vehicle localization using 3D LIDAR (Velodyne HDL-32E) is performed in the urban area. As there are many tall buildings in the urban area and the outer walls of urban buildings consist of planes generally perpendicular to the earth's surface, the outer wall of the building meets at a vertical corner and this vertical corner can be accurately extracted using 3D LIDAR. In this paper, we describe the vertical corner extraction method using 3D LIDAR and perform the precise localization by combining the extracted corner position and GPS/DR information. The driving test was carried out in an about 4.5 km-long section near Teheran-ro, Gangnam. The lateral and longitudinal RMS position errors were 0.146 m and 0.286 m, respectively and showed very accurate localization performance.

      • Serum Procalcitonin for Differential Diagnosis of Acute Exacerbation and Bacterial Pneumonia in Patients With Interstitial Lung Disease

        Sim, Jae Kyeom,Oh, Jee Youn,Lee, Eun Joo,Hur, Gyu Young,Lee, Seung Heon,Lee, Sung Yong,Lee, Sang Yeub,Kim, Je Hyeong,Shin, Chol,Shim, Jae Jeong,In, Kwang Ho,Kang, Kyung Ho,Min, Kyung Hoon Elsevier 2016 The American journal of the medical sciences Vol.351 No.5

        <P>Background: Acute exacerbation and bacterial pneumonia are major life-threatening conditions in patients with interstitial lung disease (ILD). The rapid recognition of these 2 different conditions is important for their proper treatment. An elevated procalcitonin (PCT) level is commonly detected in patients with bacterial infections. This study assessed the usefulness of the serum PCT level as a biomarker for the differential diagnosis of acute exacerbation and bacterial pneumonia in patients with ILD. Materials and Methods: In this prospective observational study, we enrolled patients with ILD who had experienced recently progressive dyspnea and exhibited new infiltrations on chest radiographs. We classified these patients into an acute exacerbation group and a bacterial pneumonia group and compared their baseline characteristics and laboratory parameters, including the PCT level. Results: Of 21 patients with ILD, 9 patients had bacterial pneumonia. Both the groups showed similar baseline characteristics. The bacterial pneumonia group demonstrated a high PCT level. The PCT level in the acute exacerbation group was significantly lower than that in the bacterial pneumonia group (0.05 versus 0.91ng/mL, respectively; P < 0.001). Other parameters, such as the C-reactive protein level, leukocyte count and body temperature, were also lower in the acute exacerbation group. At a cutoff value of 0.1ng/mL, the sensitivity, specificity and negative predictive values of the serum PCT level were 88.9%, 100.0% and 92.3%, respectively. Conclusions: These findings suggest that the serum PCT level is useful in the differential diagnosis of acute exacerbation and bacterial pneumonia in patients with ILD.</P>

      • KCI등재

        자가면역성 뇌척수염 흰쥐의 활성화된 신경아교세포에서 증가된 osteopontin의 발현

        박석재,황인선,김규범,신태균,지영흔,Park, Suk-jae,Hwang, In-sun,Kim, Gyu-beom,Shin, Tae-kyun,Jee, Young-heun 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.3

        Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). Autoimmune inflammation is maintained by secretion of a large number of protein. Previous studies have suggested that transcripts encoding osteopontin (OPN) are frequently detected in the mRNA population of MS plaques. To elucidate the functional role of OPN in initiation and development of EAE, we examined the expression and localization of OPN in the spinal cord during acute EAE. We demonstrated that OPN significantly increased at the early stage of EAE and slightly declined thereafter by western blot analysis. An immunohistochemical study revealed that OPN was constitutively expressed in some glial cells (microglia, astrocytes) of white matter and neurons in the CNS of control rats. OPN expression was shown to be increased in the same cells at the early and peak stage of EAE. To identity cells expressing OPN by double-immunofluorescence labeling, we labeled rat spinal cord sections for OPN with a monoclonal OPN antibody and with mAbs for astrocyte (GFAP), microglia/macrophage (OX42)-specific markers. The major cell types of OPN-expressing cells were activated astrocytes and microglia in the adjacent inflammatory lesions. Interestingly, OPN was mainly expressed in the end feet of astrocytes around vascular cell adhesion molecule-1 (VCAM-1) expressing endothelial cells of CNS blood vessel. These findings suggest that increased levels of OPN in activated glial cell may play an important role in the recruitment of inflammatory cells into the CNS parenchyma during EAE.

      • SCIESCOPUSKCI등재

        한국인에서 만성소화장애증 선별검사인 조직 트랜스글루타미나제 항체 검사의 임상적 가치

        박재명 ( Jae Myung Park ),최명규 ( Myung Gyu Choi ),백창렬 ( Chang Nyol Paik ),오정환 ( Jung Hwan Oh ),조유경 ( Yu Kyung Cho ),이인석 ( In Seok Lee ),김상우 ( Sang Woo Kim ),정인식 ( In Sik Chung ),오은지 ( Eun Jee Oh ),박연준 ( Y 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.1

        목적: 만성소화장애증의 증상은 과민성장증후군과 유사하여, 서양에서는 과민성장증후군 진단과정 중에 만성소화장애증의 배제가 권고되고 있다. 본 연구의 목적은 한국인 기능성 위장관 장애의 진료에서 만성소화장애증 선별검사의 의의를 알아보는 것이다. 대상 및 방법: 소화기내과를 방문한 총 694명의 연속적으로 수집된 환자를 대상으로 하였다. 만성소화장애증 선별검사법은 민감도와 특이도가 높은 조직 트랜스글루타미나제 항체 검사법을 사용하였다. 결과: 환자의 나이는 58세(16세-96세), 남자는 388명이었다. 기능성 위장관 장애는 128명이었고, 기질적 장질환 환자는 모두 566명이었다. 조직 트랜스글루타미나제 항체 양성으로 나온 환자는 총 6명(양성율 0.86%)이었으며, 기능성 소화불량증, 크론병, 식도궤양, 간암, 감염성 대장염, 담낭염 환자였다. 항체 양성 환자들은 만성소화장애증을 의심할 만한 증상, 검사실 및 내시경 소견이 없어서 위양성으로 판독하였다. 만성소화장애증의 진단기준을 충족하는 환자 1예는 조직 트랜스글루타미나제 항체 음성이어서 위음성으로 판독하였다. 조직 트랜스글루타미나제 항체 검사의 특이도는 99.1%로 매우 높았다. 과민상장증후군 환자 49명 모두 조직 트랜스글루타미나제 항체 음성이었다. 결론: 한국에서는 기능성 위장관 장애의 진단적 접근 방식으로 만성소화장애증의 혈청학적 선별 검사법은 의의가 매우 낮을 것으로 생각된다. Background/Aims: Screening for celiac disease is recommended as part of the evaluation for irritable bowel syndrome in the Western countries due to the similarities in symptoms in the two diseases. The aim of this study was to investigate whether screening for celiac disease would be important in patients with functional gastrointestinal (GI) disorders in Korea. Methods: A total of 694 patients, who visited the GI clinic, were enrolled consecutively. Screening was performed by human recombinant anti-tissue transglutaminase (anti-tTG) IgA ELISA assay. Results: 128 patients with functional GI disorders, who met the Rome II criteria, and 566 patients with organic GI disorders were subjected to this evaluation. Anti-tTG was positive in six patients (0.86%). None of the six patients met the diagnostic criteria for celiac disease, and the antibody positive results were regarded as false positive results. The final diagnoses for these six patients were: functional dyspepsia, Crohn`s disease, esophageal ulcer, hepatocellular carcinoma, infectious colitis and cholecystitis One patient fulfilled the diagnostic criteria of celiac disease; however, the antibody test was negative in this patient. The specificity of anti-tTG was 99.1%. The antibody tests for all patients with functional colonic disorders were negative. Conclusions: Screening for celiac disease did not add any benefit to the evaluation of Korean patients with the functional GI disorders. (Kor J Neurogastroenterol Motil 2006;12:35-40)

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