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Jeong, Young-IL,Cha, Byungyoul,Lee, Hye Lim,Song, Yeon Hui,Jung, Yun Hye,Kwak, Tae Won,Choi, Changyong,Jeong, Gyeong-Won,Nah, Jae Woon,Kang, Dae Hwan Elsevier/North Holland 2017 International journal of pharmaceutics Vol.532 No.1
<P><B>Abstract</B></P> <P>The polysaccharide chitosan has abundant cationic amine groups, and can form ion-complexes with anionic molecules such as the strong photosensitizer chlorin e6 (Ce6). In this study, water-soluble chitosan (WSC) was used to fabricate Ce6-incorporated nanophotosensitizers (Abbreviated as ChitoCe6 nanophotosensitizer) via a self-assembling process. This was accomplished by dissolving WSC in pure water and then directly mixing the solution with solid Ce6 causing ion complex formation between WSC and Ce6. The resulting nanophotosensitizer was spherical in shape and had a particle size of less than 300nm. The photodynamic effect of ChitoCe6 nanophotosensitizer was evaluated using gastrointestinal (GI) cancer cells. At <I>in vitro</I> study using SNU478 cholangiocarcinoma cells, ChitoCe6 nanophotosensitizer showed improved Ce6 uptake by tumor cells, reactive oxygen species production, and cellular phototoxicity. An <I>in vivo</I> study using SNU478-bearing nude mice showed that the ChitoCe6 nanophotosensitizer efficiently accumulated in the tumor tissue and inhibited tumor growth more than treatment with Ce6 alone. Furthermore, ChitoCe6 nanophotosensitizer was also efficiently absorbed through tissue layers in an <I>ex vivo</I> study using porcine bile duct explants. ChitoCe6 nanophotosensitizer showed enhanced photosensitivity and photodynamic effects against cancer cells <I>in vitro</I> and <I>in vivo</I>. We present ChitoCe6 nanophotosensitizer as a promising candidate for photodynamic therapy of GI cancer.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Won Sung Kim ),( Gyeong Jo Byeon ),( Bong Jae Song ),( Hyeon Jeong Lee ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.58 No.4
Background: The current study evaluated whether the level of preoperative anxiety assessed by the state-trait anxiety inventory (STAI) affects cardiovascular response during anesthetic induction. Furthermore, we evaluated the utility of the preoperative anxiety scale as a predictive factor for hemodynamic changes. Methods: One hundred twenty patients who were scheduled to undergo elective surgery under general anesthesia were enrolled in this prospective study. The patients were asked to fill out STAI questionnaires the night before the day of surgery. For 5 minutes after tracheal intubation, changes in vital signs were recorded. The correlation between STAI scores and the percent changes in vital signs during the induction of anesthesia for each subgroup was assessed. In addition, the predictability of the 20% change in vital signs by STAI scores was analyzed using receiver operating characteristics curves. Results: The state anxiety scores of patients 45 years of age or older showed a significant correlation with percent changes in mean blood pressure and heart rate, whereas the state anxiety scores in other subgroups showed no significant correlation with changes in vital signs during the induction of anesthesia. Furthermore, the state anxiety scores in patients 45 years of age or older were shown to be useful in predicting a 20% change in vital signs during anesthetic induction. Conclusions: The state anxiety scores of patients 45 years of age or above could be a useful tool for predicting changes in vital signs during anesthetic induction. Thus, physician should be mindful of preoperative anxiety. (Korean J Anesthesiol 2010; 58: 328-333)
Jeong, Rak-Hun,Lee, Dae-Young,Cho, Jin-Gyeong,Lee, Sang-Min,Kang, Hee-Cheol,Seo, Woo-Duck,Kang, Hwang-Won,Kim, Ji-Young,Baek, Nam-In The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.6
Fresh and chopped aerial parts of $Oryza$ $sativa$ were extracted in 80% aqueous mehthanol, and the concentrated extract was successively partitioned using $n$-hexane, ethyl acetate (EtOAc), $n$-butanol, and $H_2O$. From the EtOAc fraction, a new flavonolignan (2) and a known flavonolignan, salcolin B (1), were isolated through repeated $SiO_2$ and octadecyl silica gel column chromatography. Based on NMR, mass spectrometer, and IR spectroscopic data, the chemical structure of compound (2) was determined to be tricin-4'-$O$-[erythro-${\beta}$-guaiacyl-(7"-$O$-methyl)-glyceryl] ether, which has thus far never been reported and was named salcolin C (2). Salcolin B (1) and salcolin C (2) dose-dependently inhibited nitric oxide production in RAW 264.7 cells with $IC_{50}$ values of $29.8{\pm}0.6$ and $10.8{\pm}1.0{\mu}m$, respectively, without visible toxic effect.
The introduction of a perovskite seed layer for high performance perovskite solar cells
Jeong, Jaeki,Kim, Hak-Beom,Yoon, Yung Jin,An, Na Gyeong,Song, Seyeong,Kim, Jae Won,Kim, Minjin,Jang, Hyungsu,Kim, Dong Suk,Kim, Gi-Hwan,Kim, Jin Young The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.41
<P>Processing for obtaining compact and uniform perovskite photoactive layers has been intensively studied over the last few years to achieve high power conversion efficiencies (PCEs) in solar cells. Particularly, high quality crystal growth of perovskite layers is critical to enhance device performance. We demonstrate an easy and effective new process for high efficiency p-i-n planar heterojunction structures of perovskite solar cells (PeSCs) by using a compact seed perovskite layer (CSPL). The CSPL assists vertical growth of perovskite crystals and obtains the highly crystalline perovskite photoactive layer, which leads to the reduction in the charge transfer resistance and a longer photoluminescence lifetime. The PeSC device with a CSPL shows a remarkably improved PCE, from 15.07% to 19.25%, with a record open circuit voltage (<I>V</I>OC) of 1.16 V in the p-i-n structure with pure crystal perovskite and negligible current density-voltage hysteresis. Additionally, a PCE of 20.37% was achieved in CSPL assisted n-i-p structure PeSCs.</P>