Heat Wave and Mortality: A Multicountry, Multicommunity Study

Guo, Yuming,Gasparrini, Antonio,Armstrong, Ben G.,Tawatsupa, Benjawan,Tobias, Aurelio,Lavigne, Eric,Coelho, Micheline de Sousa Zanotti Stagliorio,Pan, Xiaochuan,Kim, Ho,Hashizume, Masahiro,Honda, Yasu Environmental Health Perspectives 2017 Environmental health perspectives Vol.125 No.8

<P><B>Background:</B></P><P>Few studies have examined variation in the associations between heat waves and mortality in an international context.</P><P><B>Objectives:</B></P><P>We aimed to systematically examine the impacts of heat waves on mortality with lag effects internationally.</P><P><B>Methods:</B></P><P>We collected daily data of temperature and mortality from 400 communities in 18 countries/regions and defined 12 types of heat waves by combining community-specific daily mean temperature [FORMULA OMISSION], 92.5th, 95th, and 97.5th percentiles of temperature with duration [FORMULA OMISSION], 3, and 4 d. We used time-series analyses to estimate the community-specific heat wave–mortality relation over lags of 0–10 d. Then, we applied meta-analysis to pool heat wave effects at the country level for cumulative and lag effects for each type of heat wave definition.</P><P><B>Results:</B></P><P>Heat waves of all definitions had significant cumulative associations with mortality in all countries, but varied by community. The higher the temperature threshold used to define heat waves, the higher heat wave associations on mortality. However, heat wave duration did not modify the impacts. The association between heat waves and mortality appeared acutely and lasted for 3 and 4 d. Heat waves had higher associations with mortality in moderate cold and moderate hot areas than cold and hot areas. There were no added effects of heat waves on mortality in all countries/regions, except for Brazil, Moldova, and Taiwan. Heat waves defined by daily mean and maximum temperatures produced similar heat wave–mortality associations, but not daily minimum temperature.</P><P><B>Conclusions:</B></P><P>Results indicate that high temperatures create a substantial health burden, and effects of high temperatures over consecutive days are similar to what would be experienced if high temperature days occurred independently. People living in moderate cold and moderate hot areas are more sensitive to heat waves than those living in cold and hot areas. Daily mean and maximum temperatures had similar ability to define heat waves rather than minimum temperature. https://doi.org/10.1289/EHP1026</P>

Finite Time State Estimation of Complex-valued BAM Neutral-type Neural Networks with Time-varying Delays

Runan Guo,Ziye Zhang,Chong Lin,Yuming Chu,Yongmin Li 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.3

This paper considers the finite time state estimation problem of complex-valued bidirectional associativememory (BAM) neutral-type neural networks with time-varying delays. By resorting to the Lyapunov functionapproach, the Wirtinger inequality and the reciprocally convex approach, a delay-dependent criterion in terms ofLMIs is established to guarantee the finite-time boundedness of the error-state system for the addressed system. Meanwhile, an effective state estimator is designed to estimate the network states through the available outputmeasurements. Finally, a numerical example is presented to demonstrate the effectiveness of the proposed results.

Effect of Dietary β-1,3/1,6-glucan Supplementation on Growth Performance, Immune Response and Plasma Prostaglandin E₂, Growth Hormone and Ghrelin in Weanling Piglets

Wang, Zhong,Guo, Yuming,Yuan, Jianmin,Zhang, Bingkun Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.5

The experiment was conducted to evaluate the effect of ${\beta}$-1,3/1,6-glucan on growth performance, immunity and endocrine responses of weanling piglets. One hundred and eighty weanling piglets (Landrace$\times$Large White, $7.20{\pm}0.25kg$ BW and $28{\pm}2$ d of age) were randomly fed 1 of 5 treatment diets containing dietary ${\beta}$-1,3/1,6-glucan supplemented at 0, 25, 50, 100 and 200 mg/kg for 4 wks. Each treatment was replicated in 6 pens containing 6 pigs per pen. On d 14 and 28, body weight gain, feed consumption and feed efficiency were recorded as measures of growth performance. Peripheral blood lymphocyte proliferation and serum immunoglobulin G (IgG) were measured to study the effect of dietary ${\beta}$-1,3/1,6-glucan supplementation on immune function. Plasma prostaglandin E2 (PGE2), growth hormone (GH) and ghrelin were measured to investigate endocrine response to ${\beta}$-1,3/1,6-glucan supplementation. Our results suggest that average daily gain (ADG) and feed efficiency had a quadratic increase trend with dietary ${\beta}$-1,3/1,6-glucan supplementation from d 14 to 28, whereas it had no significant effect on average daily feed intake (ADFI). The treatment group fed with 50 mg/kg dietary ${\beta}$-1,3/1,6-glucan supplementation showed a numerical increase in ghrelin, a similar change trend with ADG and no significant effect on GH. Lymphocyte proliferation indices, serum IgG and plasma PGE2 concentrations varied linearly with dietary supplementation levels of ${\beta}$-1,3/1,6-glucan on d 14. Higher levels of ${\beta}$-1,3/1,6-glucan may have a transient immuno-enhancing effect on the cellular and humoral immune function of weanling piglets via decreased PGE2. Taking into account both immune response and growth performance, the most suitable dietary supplementation level of ${\beta}$-1,3/1,6-glucan is 50 mg/kg for weanling piglets.

Effects of Dietary Iodine and Selenium on the Activities of Blood Lymphocytes in Laying Hens

Song, Zhigang,Guo, Yuming,Yuan, Jianmin Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.5

The effect of dietary iodine and selenium supplementation, alone or in combination, on peripheral blood lymphocyte function was determined in laying hens. Eight-hundred-and-sixty-four New-Loman laying hens were randomly allotted into 12 dietary treatments with different inclusion levels of iodine (0, 0.1 and 0.2 mg/kg), selenium (0, 0.05, 0.1 and 0.2 mg/kg) or their combinations for 24 weeks. The lipopolysaccharide (LPS) stimulation index, concanavalin A (ConA) stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles were tested. There were significant differences in LPS stimulation index, ConA stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles in different iodine or selenium supplementation levels (p<0.05). The highest iodine and selenium supplementation both resulted in highest LPS-/ConA-stimulation indices (p<0.05). However, when iodine was lower than 0.2 mg/kg, the additional effect of different levels of selenium did not always result in significant differences in these indices. The results indicated that iodine and selenium may affect immunity in laying hens and, when the iodine level in the laying hen is lower than 0.2 mg/kg, a selenium allowance higher than 0.1 mg/kg may be necessary to improve immunity.

Lysine Requirement of Male White Pekin Ducklings from Seven to Twenty-one Days of Age

Xie, Ming,Guo, Yuming,Zhang, Ting,Hou, Shuisheng,Huang, Wei Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.10

A dose-response experiment with five lysine levels (0.65, 0.80, 0.95, 1.10, and 1.25%) was conducted to evaluate the lysine requirement of male White Pekin ducklings from 7 to 21 days of age. Two hundred and eighty, 7-day-old, male White Pekin ducklings were allocated to 5 experimental treatments, each containing 8 replicate pens with 7 birds per pen. Feed and water were provided ad libitum from 7 to 21 days of age. At 21 days of age, weight gain, feed intake, feed/gain, breast meat weight, and breast meat yield relative to body weight of ducklings from each pen were all measured. As dietary lysine level increased, weight gain, feed intake, feed/gain, breast meat weight, and breast meat yield of ducklings were all improved significantly (p<0.05). According to broken-line regression analysis, the lysine requirement of male White Pekin ducklings from 7 to 21 days of age for weight gain, feed/gain, breast meat weight, and breast meat yield was 0.84, 0.90, 0.97, and 0.98%, respectively. Considering that Pekin duck production is directed to meat production, the lysine requirement of male starter Pekin ducklings during this period is suggested to be 0.98%.

Novel modulation method for torque ripple suppression of brushless DC motors based on SIMO DC-DC converter

Sun, Shikai,Guo, Hui,Zhang, Yimeng,Jia, Yupeng,Lv, Hongliang,Song, Qingwen,Tang, Xiaoyan,Zhang, Yuming The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.3

In this paper, a novel modulation method is proposed for the torque ripple suppression of a brushless DC motor (BLDCM) during both the commutation period and the speed regulation period. The main sources of torque ripple are the imbalance current during commutation and the PWM during speed regulation. A single-inductor multiple-output (SIMO) Buck DC-DC converter is adopted to generate input voltage for the inverter driver of a BLDCM. During the commutation period, the input voltage of an inverter can be adjusted to four times the back electromotive force (EMF), which suppresses the torque ripple caused by imbalance commutation current. Meanwhile, by changing the output voltage of a SIMO DC-DC, the speed of a BLDCM can be regulated without PWM on the inverter switches, which also suppresses the torque ripple. A control algorithm is applied on a Field Programmable Gate Array (FPGA), and the proposed BLDCM drive prototype is fabricated and tested. Measurement results show that with the proposed speed regulation strategy, the torque ripple is suppressed from 33.3% to 20.1%, and that with the proposed suppression strategy in commutation, the torque ripple is suppressed further to 5.3%.

Mortality risk attributable to high and low ambient temperature: a multicountry observational study

Gasparrini, Antonio,Guo, Yuming,Hashizume, Masahiro,Lavigne, Eric,Zanobetti, Antonella,Schwartz, Joel,Tobias, Aurelio,Tong, Shilu,Rocklö,v, Joacim,Forsberg, Bertil,Leone, Michela,De Sario, Manuela Elsevier 2015 The Lancet Vol.386 No.9991

<P><B>Summary</B></P><P><B>Background</B></P><P>Although studies have provided estimates of premature deaths attributable to either heat or cold in selected countries, none has so far offered a systematic assessment across the whole temperature range in populations exposed to different climates. We aimed to quantify the total mortality burden attributable to non-optimum ambient temperature, and the relative contributions from heat and cold and from moderate and extreme temperatures.</P><P><B>Methods</B></P><P>We collected data for 384 locations in Australia, Brazil, Canada, China, Italy, Japan, South Korea, Spain, Sweden, Taiwan, Thailand, UK, and USA. We fitted a standard time-series Poisson model for each location, controlling for trends and day of the week. We estimated temperature–mortality associations with a distributed lag non-linear model with 21 days of lag, and then pooled them in a multivariate metaregression that included country indicators and temperature average and range. We calculated attributable deaths for heat and cold, defined as temperatures above and below the optimum temperature, which corresponded to the point of minimum mortality, and for moderate and extreme temperatures, defined using cutoffs at the 2·5th and 97·5th temperature percentiles.</P><P><B>Findings</B></P><P>We analysed 74 225 200 deaths in various periods between 1985 and 2012. In total, 7·71% (95% empirical CI 7·43–7·91) of mortality was attributable to non-optimum temperature in the selected countries within the study period, with substantial differences between countries, ranging from 3·37% (3·06 to 3·63) in Thailand to 11·00% (9·29 to 12·47) in China. The temperature percentile of minimum mortality varied from roughly the 60th percentile in tropical areas to about the 80–90th percentile in temperate regions. More temperature-attributable deaths were caused by cold (7·29%, 7·02–7·49) than by heat (0·42%, 0·39–0·44). Extreme cold and hot temperatures were responsible for 0·86% (0·84–0·87) of total mortality.</P><P><B>Interpretation</B></P><P>Most of the temperature-related mortality burden was attributable to the contribution of cold. The effect of days of extreme temperature was substantially less than that attributable to milder but non-optimum weather. This evidence has important implications for the planning of public-health interventions to minimise the health consequences of adverse temperatures, and for predictions of future effect in climate-change scenarios.</P><P><B>Funding</B></P><P>UK Medical Research Council.</P>

The Modulating Effect of β-1, 3/1, 6-glucan Supplementation in the Diet on Performance and Immunological Responses of Broiler Chickens

Zhang, Bo,Guo, Yuming,Wang, Zhong Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.2

The object of this trial was to investigate the effect of dietary ${\beta}$-1,3/1,6-glucan supplementation on the performance and immunological response of broiler chickens. Two hundred and forty 1-day old male broilers ($39{\pm}1g$) were separated into six treatments which were given six different feeds containing 0 (control), 25, 50, 75, 100 and 125 mg/kg dietary ${\beta}$-1,3/1,6-glucan supplementation. On days 21 and 42, body weight gain, feed consumption and feed conversation rate were recorded as measures of growth performance. The levels of key cytokines in the immuno-regulating pathway: interleukin-1 (IL-1), interleukin-2 (IL-2), interferon $\gamma$(IFN-$\gamma$, tumor necrosis factor $\alpha$(TNF-$\alpha$, and the concentrations of signal molecules: peripheral blood plasma globulin, serum Immunoglobulin G (IgG) and intestinal secretary Immunoglobulin A (sIgA), were measured as indices of the immune response to determine suitable levels of dietary ${\beta}$-1,3/1,6-glucan supplementation. The results indicated that performance was elevated quadratically with dietary ${\beta}$-1,3/1,6-glucan supplementation. Maximal growth performance and an enhanced immunological response were obtained at a supplemented level of 50 mg/kg.

Effects of Salmonella typhymurium Lipopolysaccharide Challenge on the Performance, Immune Responses and Zinc Metabolism of Laying Hens Supplemented with Two Zinc Sources

Cheng, Tingshui,Guo, Yuming Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.12

The study was conducted to determine the effect of Salmonella typhymurium lipopolysaccharide (LPS) challenge on egg-laying performance, inflammatory response, zinc metabolism in layer fed diets supplemented with organic or inorganic zinc since 3-wk-old. The three dietary treatments were corn-soybean meal basal diet without supplemental zinc or with supplemental zinc at 60 mg/kg zinc from $ZnSO_4$ or zinc amino acid complex (ZnAA). At the age of 58 wk-old, twelve hens from each dietary treatment were allotted into two sub-groups. On day 1, 3, 5, 7 of the $58^{th}$ week of age, six birds of one sub-group were injected intraperitoneally (i.p.) with 2 ml LPS (1.0 $\ell$/ml) or sterile saline. Neither zinc source ${\times}$ immune challenge interaction nor zinc source effect on egg production performance was observed (p>0.05), LPS-challenge decreased egg production (p<0.04) and increased percentage of cracked eggs (p <0.01). With LPS challenged, the fever response of hens fed ZnAA peaked and subsided earlier than in hens fed $ZnSO_4$ or basal diet. Serum IL-1$\beta$ at 3 h was higher (p<0.01), but lower (p<0.001) at 12 h post-challenge with LPS in hens fed ZnAA than $ZnSO_4$. In salinetreated groups, serum IL 1$\beta$ was higher in hens fed ZnAA than the basal diet at 3 h post-injection (p<0.01). LPS-challenged birds had lower serum zinc and higher zinc sequestered in liver and spleen (p<0.001). In saline-treated birds, there was no difference in zinc concentration of serum, liver and spleen among different dietary treatments (p>0.05). Supplementation of 60 mg/kg zinc from either ZnAA or $ZnSO_4$ significantly (p<0.05) elevated metallothionein (MT) concentration in liver and spleen. MT concentration in liver of birds fed ZnAA diet was higher than in those fed $ZnSO_4$ diet (p<0.05). The magnitude of increase of hepatic and splenic MT due to LPS challenge was higher by supplementation of ZnAA than $ZnSO_4$. The results suggest that zinc amino acid complex enhanceed MT synthesis and zinc sequestered in liver and spleen and increased the sensitivity to immune response due to LPS challenge.

Corticosterone Administration Alters Small Intestinal Morphology and Function of Broiler Chickens

Hu, Xiaofei,Guo, Yuming Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.12

Two experiments were carried out to study the effects of corticosterone (CORT) administration on intestinal morphology and function of broilers. In both experiments, birds were randomly divided into two equal groups. One group was the control group (CTRL), and the birds were fed with a basal diet. The other was the experimental group (CORT), and the birds were fed with the basal diet plus 30 mg of CORT/kg diet. At 21 days of age, performance, morphological characteristics of intestine, D-xylose level in plasma, activities of digestive enzymes in digesta, digestibility of nutrients and 5-bromo-2-deoxyuridine (BrdUrd)-labeling index of intestinal epithelial cells were determined. CORT administration decreased feed intake, daily gain and feed conversion ratio (p<0.05). CORT also decreased duodenal and jejunal villus height (p<0.05) as well as crypt depth (p<0.05). The D-xylose level in plasma of CORT-treated broilers was lower than that of the control (p<0.05). CORT treatment caused a decrease in apparent digestibility of protein (p<0.05), whereas fat and starch apparent digestibilities were unaffected (p>0.05). CORT administration increased activities of trypsin and amylase (p<0.05), and decreased BrdUrd-labeling index of duodenal and jejunal epithelial cells (p<0.05). In conclusion, CORT administration impaired the normal morphology and absorptive capacity of the small intestine of broiler chickens.