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( Yuki Gen ),( Hui Ryeon Ju ),( Sang Il Kim ),( Sung Jong Lee ),( Dong Choon Park ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To date, a few studies have investigated the roles of autophagy in endometriosis and no study about the difference in expression of autophagy-associated mRNAs in patients with gynecologic (ovarian, uterine, and cervical) cancers. This study therefore compared the levels of expression of autophagy-associated genes in patients with endometriosis and gynecologic cancers. Methods: The levels of expression of autophagy mRNAs, including those encoding mTOR, P13KC3, Beclin-1, Bcl-2, LC3 II, FLIP, Rubicon, BIRC2 and BIRC5 were measured by real time polymerase chain reaction in peritoneal fluid of 39 patients with benign masses (control group), 42 patients with endometriosis, and 57 patients with gynecologic (ovarian, uterine, and cervical) cancers. Findings in the three groups were compared. Results: Autophagy mRNAs were present in all endometriosis and gynecologic cancer fluid samples. The levels of PI3K, FLIP, and Rubicon mRNAs significantly higher in the endometriosis than in the control group (p<0.05 each). Compared with the gynecologic cancer group, the level of LC3II and FLIP mRNA was significantly lower, and the levels of Beclin-1 and Rubicon mRNAs significantly higher in the endometriosis group (p<0.05 each). The expression of PI3K and FLIP mRNA in the peritoneal fluid of the endometriosis and gynecologic cancer groups were significantly increased compared to those of control group(p<0.05 each). Conclusion: PI3K, FLIP, and Rubicon mRNAs are closely associated in the pathogenesis of endometriosis. The increased expression of PI3K and FLIP mRNA in the peritoneal fluid of the endometriosis and gynecologic cancer groups suggests that endometriosis and gynecologic cancers have similar autophagic characteristics. And Beclin-1 mRNA was decreased in the female cancer group compared to the control and endometriosis group, and the decrease of Beclin-1 mRNA in the benign and endometriosis increased the possibility of the gynecologic tumor.
A probe method for the inverse boundary value problem of non-stationary heat equations
Daido, Yuki,Kang, Hyeonbae,Nakamura, Gen Institute of Physics 2007 Inverse problems Vol.23 No.5
<P>An inverse problem for identifying an inclusion inside an isotropic homogeneous heat conductive medium is considered. The shape of the inclusion may vary depending on time. For the one space dimensional case, we develop an analogue of the probe method known for inverse boundary value problems for elliptic equations and give a reconstruction procedure for identifying the inclusion from the Neumann to Dirichlet map.</P>
Risk factors for high neonatal serum magnesium concentrations in prenatal maternal magnesium therapy
( Hong Yeon Lee ),( Hyun Sik Chung ),( Hyun Sun Ko ),( Sae Kyung Choi ),( Yuki Gen ),( Su Mi Kim ),( Jae Eun Shin ),( Ki Cheol Kil ),( Yeon Hee Kim ),( Jeong Ha Wie ),( Yun Sung Jo ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: The main purpose of this study is to analyze the risk factors for high neonatal serum magnesium concentrations in prenatal maternal magnesium therapy. Methods: This was a retrospective study that employed the electronic medical record systems of seven tertiary care centers under the College of Medicine, the Catholic University of Korea, from January 2009 to March 2021. This study was approved to use registry data and documentation of informed consent was waived by our Institutional Review Board (XC20WIDI0103/2020-2158-0020). Mothers who received antenatal magnesium sulfate for neuro-protection or eclampsia prophylaxis were included. This study evaluated mother-neonate pairs with each having one documented magnesium concentration measured from the blood. Results: A total of 877 mother -neonate pairs of magnesium concentration were obtained. Mothers of neonates with high neonatal magnesium concentrations (>4.5mg/dL) had high maternal magnesium concentrations, lower GFR, lower gestational age at delivery, and were more like to have preeclampsia. Conclusion: We have identified several predictors of neonatal serum magnesium concentrations that can guide maternal magnesium dose.
Sclerosing encapsulating peritonitis after living-donor liver transplantation
Vusal Aliyev,Shintaro Yagi,Ahmed Hammad,Amr Badawy,Yudai Sasaki,Yuki Masano,Gen Yamamoto,Naoko Kamo,Kojiro Taura,Hideaki Okajima,Toshimi Kaido,Shinji Uemoto 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.2
Sclerosing encapsulating peritonitis (SEP), or abdominal cocoon is a rare cause of intestinal obstruction, and still etiology remains unknown. We report a series of 4 patients with abdominal cocoon, and all the 4 patients had previously undergone living-donor liver transplantation (LDLT). There was no evidence of SEP before and during LDLT. At the time of diagnosis of SEP, 3 out of 4 patients had ascites. First and fourth patients had multiple episodes or attacks of cholangitis, which were managed by percutaneous transhepatic biliary drainage and hepaticojejunostomy, respectively. All 4 patients presented with intestinal obstruction and 3 of them underwent a successful operation. The fourth patient died due to liver failure and complications of the SEP. The first 3 patients are doing well without SEP recurrence. Our experience suggest that the prognosis of SEP is poor in patients with poor graft liver functions after LDLT.
Hidefumi Inaba,Yosuke Kaido,Saya Ito,Tomonao Hirobata,Gen Inoue,Takakazu Sugita,Yuki Yamamoto,Masatoshi Jinnin,Hiroaki Kimura,Tomoko Kobayashi,Shintaro Iwama,Hiroshi Arima,Takaaki Matsuoka 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.1
Background: Type 1 diabetes mellitus induced by immune-checkpoint inhibitors (ICI-T1DM) is a rare critical entity. However, the etiology of ICI-T1DM remains unclear. Methods: In order to elucidate risk factors for ICI-T1DM, we evaluated the clinical course and immunological status of patients with ICI-T1DM who had been diagnosed during 2016 to 2021. Results: Seven of 871 (0.8%, six men and one woman) patients developed ICI-T1DM. We revealed that the allele frequencies of human leukocyte antigen (HLA)-DPA1*02:02 and DPB1*05:01 were significantly higher in the patients with ICI-T1DM In comparison to the controls who received ICI (11/14 vs. 10/26, P=0.022; 11/14 vs. 7/26, P=0.0027, respectively). HLA-DRB1*04:05, which has been found to be a T1DM susceptibility allele in Asians, was also observed as a high-risk allele for ICI-T1DM. The significance of the HLA-DPB1*05:01 and DRB1*04:05 alleles was confirmed by an analysis of four additional patients. The absolute/relative neutrophil count, neutrophils-lymphocyte ratio, and neutrophil-eosinophil ratio increased, and the absolute lymphocyte count and absolute/relative eosinophil count decreased at the onset as compared with 6 weeks before. In two patients, alterations in cytokines and chemokines were found at the onset. Conclusion: Novel high-risk HLA alleles and haplotypes were identified in ICI-T1DM, and peripheral blood factors may be utilized as biomarkers.
Robotic surgery in Gynecology: the present and the future
JungYoon Park,SeongEun Bak,Jae-Yen Song,Youn-Jee Chung,Gen Yuki,Su Jeong Lee,Jisu Mun,Mee-Ran Kim 대한산부인과학회 2023 Obstetrics & Gynecology Science Vol.66 No.6
Since its introduction, laparoscopic surgery has been often preferred over open surgery in obstetrics and gynecology due to its advantages, such as less bleeding, lower incidence of adhesions, reduced postoperative pain, short hospital stay, and quick return to daily life. However, in the case of complex surgeries, laparoscopy presented some limitations. Nonetheless, since the 1980s, medical robots have been introduced to overcome the technical limitations of laparoscopy and start a new age for minimally invasive surgery. In this review, we explore the indications and advantages and disadvantages of robotic surgery in the field of gynecology, and try to assess the recent trend of robotic surgery.
Re-epithelialization of the Buccal Mucosa after Alkaline Chemical Injury
Takaichi, Saneyuki,Muramatsu, Takashi,Lee, Jong-Min,Jung, Han-Sung,Shinozaki, Naoshi,Katakura, Akira,Yamane, Gen-yuki JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2014 Acta histochemica et cytochemica Vol.47 No.5
<P>Alkaline conditions in the oral cavity may be caused by a variety of stimuli, including tobacco products, antacids, alkaline drinking water and bicarbonate toothpaste. However, the effects of an alkaline pH on the oral mucosa had not been elucidated. The purpose of this study was to investigate how basal keratinocytes are actively involved in re-epithelialization after alkaline chemical injury. We generated epithelial defects in the oral mucosa of mice by applying an alkaline chemical, and the localization of cytokeratin 13, cytokeratin 14, PCNA and p63 was investigated during the re-epithelialization process. PCNA- and p63-positive staining was seen in basal cells covering the wound surface at 1 day after the chemical injury. Cytokeratin 14-positive and PCNA-negative basal keratinocytes were localized in a few layers of the wound epithelium during epithelial outgrowth. Cytokeratin 14-positive and PCNA-positive basal keratinocytes, indicating proliferation, were localized over the entire layer of the epithelium at the wound margin. These results imply that basal keratinocytes at the wound margin migrate to the wound surface, provoke differentiation and keratinization during epithelial outgrowth and that epithelial cells are supplied from the wound margin to the epithelial outgrowth after alkaline chemical injury.</P>