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RISS 인기검색어
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- 저자 : Fu Hongxia (검색결과 6 건)
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Durability Model of Exposed Concrete On-Site Based on Dual Coupling Factors
Yong Fu,Hongxia Qiao,Chenggong Lu,Theogene Hakuzweyezu,Fei Guo 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1
Aiming at the problem that the reliability analysis of the outdoor exposed concrete structure under the action of a single factor is not consistent with the actual service environment, a reliability analysis based on the Copula function describing multiple degradation factors is proposed. According to the actual data collected on-site, the relative quality evaluation parameters (RQEP) and relative dynamic elastic modulus evaluation parameters (RDEMEP) was selected as the key degradation indicators, and the Aperture Information Criterion (AIC) was used to determine the optimal marginal distribution function in different degradation trajectories, and obtain the most optimal edge distribution function under a single factor. Optimize the edge distributions reliability curve, establish the relationship between the edge distributions through the Copula function, and couple the edge distributions of the remaining life of the concrete to obtain the joint reliability function of the concrete under the action of the coupling factors. The results show that the selection of two degradation indicators, RQEP and RDEMEP, is helpful in establishing the concrete life prediction model in the field exposure environment, and the RDEMEP are more sensitive to the field exposure environment than the RQEP. The Gumbel Copula distribution function can reasonably predict the reliability of exposed concrete on-site under dual coupling factors. The service life of C40 and C50 exposed concrete on site is about 400 and 550 months, respectively.
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Li, Xiaolin,Fu, Jie,Shi, Wei,Luo, Yin,Zhang, Xiaowei,Zhu, Hailiang,Yu, Hongxia Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.8
Benzotriazole is an important synthetic auxiliary for potential clinical applications. A series of benzotriazoles as potential antiproliferative agents by inhibiting histone deacetylase (HDAC) were recently reported. Three-dimensional quantitative structure-activity relationship (3D-QSAR), including comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), were performed to elucidate the 3D structural features required for the antiproliferative activity. The results of both ligand-based CoMFA model ($q^2=0.647$, $r^2=0.968$, ${r^2}_{pred}=0.687$) and CoMSIA model ($q^2=0.685$, $r^2=0.928$, ${r^2}_{pred}=0.555$) demonstrated the highly statistical significance and good predictive ability. The results generated from CoMFA and CoMSIA provided important information about the structural characteristics influence inhibitory potency. In addition, docking analysis was applied to clarify the binding modes between the ligands and the receptor HDAC. The information obtained from this study could provide some instructions for the further development of potent antiproliferative agents and HDAC inhibitors.
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EXPLORE THE IMPACT OF TOURIST-TO-TOURIST ON TOURISM EXPERIENCE: A SELF-DISCLOSURE PERSPECTIVE
Meng Zhang,Hongxia Lin,Xiaorong Fu 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Human beings are intrinsically social. How social interaction among tourists affect their experience remains under-represented. Drawing on S-O-R theory, social integration theory and social penetration theory, this study proposes and empirically tests a conceptual model that integrates self-disclosure, perceived cohesion, perceived intimacy, tourist engagement and tourist satisfaction with the experience. Also, the tie strength is theorized as a moderator in the relationship between self-disclosure and perceived cohesion as well as perceived intimacy. A field experiment was undertaken to collect data. The results from the structural analysis suggest that self-disclosure influences perceived cohesion and perceived intimacy, which in turn influence their engagement and satisfaction with tourism experience. Moreover, the initial tie strength has moderation effect on the relationship between self-disclosure and perceived cohesion as well as perceived intimacy. Overall, findings of this study contributes to the development of tourism experience research from the perspective of tourist-to-tourist interaction, and broadens the research on tourist engagement. Discussions and implications for tourism operators, limitations, and suggestions for future research are also provided.
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Liposome Formulation of Paclitaxel with Enhanced Solubility and Stability
Yang, Tao,Cui, Fu-De,Choi, Min-Koo,Lin, Hongxia,Chung, Suk-Jae,Shim, Chang-Koo,Kim, Dae-Duk Informa Healthcare 2007 DRUG DELIVERY Vol.14 No.5
<P> Despite its strong antitumor activity, paclitaxel (Taxol®) has limited clinical applications due to its low aqueous solubility and hypersensitivity caused by Cremophor® EL and ethanol which is the vehicle used in the current commercial product. In an attempt to develop a pharmaceutically acceptable formulation that could replace Taxol®, a paclitaxel incorporated liposome has been constructed to improve solubility and physicochemical stability. The effect of various components of the liposome, including cholesterol and lipid, on the solubility and entrapment efficiency (EE) of paclitaxel was systematically investigated. The results showed that 5% (v/v) of polyethylene glycol 400 in the hydration medium of liposome significantly increased the solubility (up to 3.39 mg/mL) as well as the EE and the paclitaxel content in the liposome formulation composed of 10% (w/v) of S100PC with cholesterol (cholesterol-to-lipid molar ratio = 10:90). When sucrose (sugar-to-lipid molar ratio = 2.3) was added as a lyoprotectant during the freeze-drying of the liposome, physicochemical stability of liposome was significantly improved. Moreover, the cytotoxicity of the final liposome formulation against MDA-MB-231 human breast cancer cell line was not significantly different from that of Taxol®. The enhanced aqueous solubility as well as the physicochemical stability of paclitaxel in the liposome formulation developed in this study could be a safer and effective alternative to the Cremophor® EL and ethanol formulation.</P>
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Xiaolin Li,Jie Fu,Wei Shi,Yin Luo,Xiaowei Zhang,Hailiang Zhu,Hongxia Yu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.8
Benzotriazole is an important synthetic auxiliary for potential clinical applications. A series of benzotriazoles as potential antiproliferative agents by inhibiting histone deacetylase (HDAC) were recently reported. Threedimensional quantitative structure-activity relationship (3D-QSAR), including comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), were performed to elucidate the 3D structural features required for the antiproliferative activity. The results of both ligand-based CoMFA model (q2 = 0.647, r2 = 0.968, r2 pred = 0.687) and CoMSIA model (q2 = 0.685, r2 = 0.928, r2 pred = 0.555) demonstrated the highly statistical significance and good predictive ability. The results generated from CoMFA and CoMSIA provided important information about the structural characteristics influence inhibitory potency. In addition, docking analysis was applied to clarify the binding modes between the ligands and the receptor HDAC. The information obtained from this study could provide some instructions for the further development of potent antiproliferative agents and HDAC inhibitors.
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