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Case Series Study on the Use of BU Pharmacopuncture Treatment in Patients with Acute Lumbar Sprain
Yang, Muhack,Jang, Jongwon,Cha, Eunhye,Ahn, Byungsoo,Bang, Younghee,Song, Beomyong,Shin, Jiyong,Ahn, Chankeun,Kim, Deokho,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.2
Objective: The purpose of this study was to investigate the clinical effects of BU pharmacopuncture therapy consisting of bear's gall(fel ursi) and ox bezoar(bovis calculus) on acute lumbar sprain. Methods: 12 patients diagnosed as acute lumbar sprain in 6 designated local Korean medicine clinics from October 2017 to February 2018 were treated by BU pharmacopuncture. Several acupoints in abdomen and lumbar region were selected by clinicians at their own discretion. The effectiveness of the therapy was evaluated using VAS and ODI. After that we reviewed the medical records of all these patients to evaluate the effectiveness and safety of the therapy. Results: The VAS and ODI scales were significantly decreased after BU pharmacopuncture therapy. And no major complications and adverse effects were reported. Conclusion: BU pharmacopuncture showed rapid pain relief in patients with acute lumbar sprain. It is possible to shorten the treatment period of acute lumbar sprain and prevent progressing to chronic back pain in advance. To establish the effects of BU pharmacopuncture therapy, more succeeding clinical and laboratory studies are needed.
A case of splenic extraskeletal mesenchymal chondrosarcoma in a Yorkshire Terrier dog
( Eunhye Jung ),( Hyoung-seok Yang ),( Ji-youl Jung ),( Jae-hoon Kim ) 한국동물위생학회 2023 韓國家畜衛生學會誌 Vol.46 No.4
A 7-year-old male Yorkshire Terrier dog was present to an animal clinic and a large soft mass was found in the spleen by radiological examination, and total splenorectomy was performed. Grossly, a large protruded splenic mass was soft to moderately firm and multilobulated. On the cut surface, the mass was off-white to tan, dark red, and rust colored with many cavitation and had gelatinous areas. Histologically, the tumor cells were characterized by coexistence of the primitive mesenchymal tissues and mature or immature cartilage tissues. Primitive mesenchymal areas were composed of round/oval or spindle shaped immature cells with high mitosis. The tumor cells of the cartilage areas were located in basophilic cartilaginous matrix. Intercellular matrix in the cartilaginous areas was stained blue with Masson’s trichrome and deep blue with alcian blue, respectively. Immunohisto-chemically, the cartilaginous tumor cells demonstrated positive reactions for vimentin and S-100, and surrounding mesenchymal tumor cells are immunopositive for vimentin. This case was diagnosed as splenic extraskeletal mesenchymal chondrosarcoma of a Yorkshire Terrier dog, a toy breed.
Yang, Muhack,Kim, Jae Kyoun,Park, Gun Woo,Cha, Eunhye,Jang, Jongwon,Seo, Jihye,Lee, Sangkwan,Kim, Sungchul Korean AcupunctureMoxibustion Medicine Society 2019 Korean Journal of Acupuncture Vol.36 No.2
Background: In Korean medicine, carpal tunnel syndrome is treated by stimulating the acupoints around the wrist. Although a deep understanding of anatomy and guidance is needed to stimulate these acupoints to avoid undesirable side-effects, currently there are no published guidelines for acupotomy treatment. The aim of this study is to evaluate the effectiveness and safety of fluoroscopy-guided acupotomy compared with conventional acupotomy treatment. Methods: This is a randomized, patient-assessor, patient blind, parallel clinical trial. A total of 30 patients will be enrolled at Wonkwang University Gwangju Hospital, and will be allocated to either an experimental group or a control group. The experimental group will be treated using fluoroscopy-guided acupotomy and the control group will be treated using the conventional acupotomy method. Results: The primary outcome measure will be identification of a cross-section area of the median nerve measured by ultrasonography, and the secondary outcome measure will be the alleviation of pain measured by the Visual Analogue Scale, improvement in the Nerve Conduction Study, Tinel test, Phalen's test, EuroQol 5-dimension scale, and Boston Carpal Tunnel Questionnaire score. Safety components will be measured by monitoring vital signs, electrocardiographs, blood tests, general chemical tests, urine tests and pregnancy tests. In addition, observations for adverse effects will be performed during the trial. Conclusion: This study will provide a more effective, and less harmful way of treating carpal tunnel syndrome compared with conventional acupotomy. Fluoroscopy-guided acupotomy will help practitioners to be accurate in direction and depth of the needle for treating carpal tunnel syndrome.
Yang, Young In,Jeong, Eunhye,Choi, Inhee,Lee, Suseung,Song, Hyeon Don,Kim, Kihoon,Choi, Yeonho,Kang, Taewook,Yi, Jongheop WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.20
<P><B>Genau hingeschaut</B>: Gewöhnliche UV/Vis‐ und TEM‐Methoden sind wegen Ensemblemittelungen und Projektionseffekten wenig geeignet, den Mechanismus des Nanopartikelwachstums aufzuklären. Einzelpartikelbeugungsspektren wurden nun genutzt, um das Aufwachsen von Gold auf Gold/Polystyrol‐Nanopartikeln zu untersuchen. Drei Muster lassen sich klar unterscheiden, und entsprechende Wachstumsmechanismen werden vorgeschlagen.</P>
Yang Jiyeon,Kwon Yunhyung,Kim Jaetae,장유진,한지연,김다애,Hye-Ran Jeong,박혜경,Shim Eunhye 질병관리본부 2021 Osong Public Health and Research Persptectives Vol.12 No.5
Objectives: We investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic on tuberculosis (TB) management in the Republic of Korea (ROK).Methods: This retrospective cross-sectional study used nationwide ROK TB notification data (98,346 cases) from 2017 to 2020. The median time from the onset of TB symptoms to treatment initiation and the compliance rates with the required timing for notification and individual case investigations were measured and compared across periods and regions affected by the COVID-19 epidemic.Results: TB diagnosis during the COVID-19 pandemic was delayed. The median time to TB treatment initiation (25 days) in 2020 increased by 3 days compared to that of the previous 3 years (22 days) (p<0.0001). In the outbreak in Seoul, Incheon, and Gyeonggi province during August, the time to TB diagnosis was 4 days longer than in the previous 3 years (p=0.0303). In the outbreak in Daegu and Gyeongbuk province from February to March 2020, the compliance rate with the required timing for individual case investigations was 2.2%p points lower than in other areas in 2020 (p=0.0148). For public health centers, the rate was 13%p lower than in other areas (80.3% vs. 93.3%, p=0.0003).Conclusion: TB diagnoses during the COVID-19 pandemic in the ROK were delayed nationwide, especially for patients notified by public-private mix TB control hospitals. TB individual case investigations were delayed in regional COVID-19 outbreak areas (Daegu and Gyeongbuk province), especially in public health centers. Developing strategies to address this issue will be helpful for sustainable TB management during future outbreaks.
26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats
Yang, Muhack,Lee, Seongjin,Wang, Tingting,Cha, Eunhye,Jang, Jongwon,Kim, Dongwoung,Song, Bong-Keun,Son, Ilhong,Kim, Joonyup,Kang, Hyung Won,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.3
Objectives: KCHO-1(Mecasin), also called Gamijakyakgamchobuja-tang originally, is a combination of some traditional herbal medicines in East Asia. This medicine has been used mainly for alleviating neuropathic pains for centuries in Korean traditional medicine. KCHO-1 was developed to treat pain, joint contracture and muscular weakness in patients with amyotrophic lateral sclerosis. This study was carried out to investigate the chronic toxicity of KCHO-1 oral administration in rats for 26 weeks. Methods: Sprague-Dawely rats were divided into four groups and 10 rats were placed in the control group and the high-dose group, respectively. Group 1 was the control group and the remaining groups were the experimental groups. In the oral toxicity study, 500 mg/kg, 1,000 mg/kg, and 2,000 mg/kg of KCHO-1 were administered to the experimental group, and 10 ml/kg of sterile distilled water was administered to the control group. Survival rate, body weight, feed intake, clinical signs, and visual findings were examined. Urinalysis, ophthalmologic examination, necropsy, organ weight, hematologic examination, blood chemical examination and histopathologic examination were performed. Results: Mortality and toxicological lesions associated with the administration of test substance were not observed in all groups. Conclusion: NOAEL(No observed adverse effect level) of KCHO-1 is higher than 2000 mg/kg/day. And, the above findings suggest that treatment with KCHO-1 is relatively safe.
Multiple mechanisms that prevent excessive brain inflammation
Yang, Myung-Soon,Min, Kyoung-Jin,Joe, Eunhye Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of neuroscience research Vol.85 No.11
<P>Inflammation of the injured brain has a double-edged effect. Inflammation protects the brain from infection, but it aggravates injury. Furthermore, brain inflammation is considered a risk factor for neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. Emerging evidence supports the activation of negative regulatory mechanisms during this process to prevent prolonged and extensive inflammation. The inflammatory stimulators themselves or products of inflammatory cells may induce the expression of negative feedback regulators, such as suppressor of cytokine signaling (SOCS)-family proteins, antioxidant enzymes, and antiinflammatory cytokines. Furthermore, death of activated microglia (major inflammatory cells in the brain) may regulate brain inflammation. Astrocytes, the most abundant cells in the brain, may also act in preventing microglial overactivation. Therefore, we propose that the extent and duration of brain inflammation is tightly regulated through the cooperation of multiple mechanisms to maximize antipathogenic effects and minimize tissue damage. © 2007 Wiley-Liss, Inc.</P>
Han, Eunhye,Kim, Young-Gu,Yang, Hee-Man,Yoon, In-Ho,Choi, Minkee American Chemical Society 2018 Chemistry of materials Vol.30 No.16
<P>To eliminate the radioisotope <SUP>137</SUP>Cs<SUP>+</SUP> from contaminated water, various inorganic ion-exchange materials have been developed. Many selective ion-exchange materials are relatively expensive and difficult to prepare, whereas conventional materials such as aluminosilicate zeolites lack ion-exchange selectivity in the presence of competing cations. Here, we report a simple but powerful strategy to significantly increase the Cs<SUP>+</SUP> selectivity of conventional zeolites. We demonstrate that encapsulation of elemental sulfur in the micropores of zeolites (NaA, NaX, chabazite, and mordenite) via vacuum sublimation can remarkably increase the selectivity toward Cs<SUP>+</SUP> in the presence of competing ions. It appears that the elemental sulfur does not provide additional adsorption sites for Cs<SUP>+</SUP> ions but increases the ion-exchange selectivity toward Cs<SUP>+</SUP> by providing additional interaction. Various analyses show that sulfur partially donates its electron to the ion-exchanged Cs<SUP>+</SUP> cations in zeolites, indicating significant Lewis acid-base interaction. According to the hard soft acid base (HSAB) theory, the enhanced Cs<SUP>+</SUP> ion-exchange selectivity can be explained by the fact that sulfur, a soft Lewis base, interacts more strongly with Cs<SUP>+</SUP><SUB>,</SUB> which is a softer Lewis acid than other alkali and alkaline earth metal cations. Because of the high intrinsic Cs<SUP>+</SUP> selectivity of bare zeolites and selectivity enhancement resulting from sulfur encapsulation, the sulfur-modified chabazite and mordenite showed highly promising Cs<SUP>+</SUP> capture ability in the presence of various competing ions.</P> [FIG OMISSION]</BR>