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RISS 인기검색어
- 검색키워드
- 저자 : Dominguez-Diaz, David (검색결과 3 건)
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Metastasis Risk Reduction Related with Beta-Blocker Treatment in Mexican Women with Breast Cancer
Parada-Huerta, E,Alvarez-Dominguez, TP,Uribe-Escamilla, R,Rodriguez-Joya, JF,Ponce-Medrano, JA Diaz,Padron-Lucio, S,Alfaro-Rodriguez, A,Bandala, C Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: Breast Cancer (BCa) is the most common malignant tumour in Mexican women. In BCa, several studies have linked ${\beta}2-adrenergic$ receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. The aim of this study was to describe Beta-Blocker (BB) treatment related with reduction of the risk of metastasis in Mexican patients with BCa. Materials and Methods: We collected data of 120 patients seen at the High-Specialty Naval General Hospital in Mexico City (HOSGENAES), all of these with a histopathological diagnosis of BCa. Four groups of patients were divided as follows: without Systemic Arterial Hypertension (SAH); with SAH treatment with non-selective BB; with SAH treatment with selective BB, and with SAH treatment with other antihypertensive drugs. Chi-square, Mantel-Haenszel, Student t, and ANOVA tests were performed for data analysis. Results: On average, patients were $54.8{\pm}11.8$ years of age. Risk factors such as smoking and consuming alcohol exhibited a frequency of 33 and 36.5% respectively. Clinical stages III- IV were found in 50% of patients, while, 30% of patients had arterial hypertension (n=29 and N=96, respectively) and 17.5% used BB. One hundred percent of patients with arterial hypertension treated with BB for ${\beta}1$ - and ${\beta}2$ -adrenergic-receptors did not present metastasis globally, but patients treated with ${\beta}1$ BB presented 30% of metastasis while patients treated with no BB or without SAH had around 70% of metastasis. Conclusions: In Mexican patients with BCa and SAH treated with non-selective (${\beta}1$- and ${\beta}2-adrenergic$ receptors) BB, a decrease in the risk for metastasis was observed at the time of diagnosis.
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Sonia Ceron,Ovier Obregon,Abdu Orduña-Diaz,Miguel A. Dominguez 한국전기전자재료학회 2022 Transactions on Electrical and Electronic Material Vol.23 No.5
In this work, the synthesis and characterization of IGZO fi lms was carried out from the individual analysis of ZnO fi lms doped at diff erent In 3+ and Ga 3+ wt.%. The thin fi lms were obtained by solution processes at low temperature (200 °C). The fi lms were characterized by X-ray Diff raction, optical transmittance, FTIR spectroscopy and resistivity. It was found that the variation of doping aff ected the content of organic residuals in the deposited fi lms. In addition, the fabrication and characterization of Metal–Insulator–Semiconductor capacitors on plastic substrates are presented. Interestingly, there was a correlation in the hysteresis with the doping of In 3+ and Ga 3+ .
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Dietary inclusion effects of phytochemicals as growth promoters in animal production
Valenzuela-Grijalva, Nidia Vanessa,Pinelli-Saavedra, Araceli,Muhlia-Almazan, Adriana,Dominguez-Diaz, David,Gonzalez-Rios, Humberto Korean Society of Animal Sciences and Technology 2017 한국축산학회지 Vol.59 No.4
Growth promoters have been widely used as a strategy to improve productivity, and great benefits have been observed throughout the meat production chain. However, the prohibition of growth promoters in several countries, as well as consumer rejection, has led industry and the academy to search for alternatives. For decades, the inclusion of phytochemicals in animal feed has been proposed as a replacement for traditional growth promoters. However, there are many concerns about the application of phytochemicals and their impact on the various links in the meat production chain (productive performance, carcass and meat quality). Therefore, the effects of these feed additives are reviewed in this article, along with their potential safety and consumer benefits, to understand the current state of their use. In summary, the replacement of traditional growth promoters in experiments with broilers yielded benefits in all aspects of the meat production chain, such as improvements in productive performance and carcass and meat quality. Although the effects in pigs have been similar to those observed in broilers, fewer studies have been carried out in pigs, and there is a need to define the types of phytochemicals to be used and the appropriate stages for adding such compounds. In regard to ruminant diets, few studies have been conducted, and their results have been inconclusive. Therefore, it is necessary to propose more in vivo studies to determine other strategies for phytochemical inclusion in the production phases and to select the appropriate types of compounds. It is also necessary to define the variables that will best elucidate the mechanism(s) of action that will enable the future replacement of synthetic growth promoters with phytochemical feed additives.
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