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Da-Hye Shin,Na-Hyeon Jung,Ji-Hye Lee,Sang-Hwan Kim,Jong-Taek Yoon 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Present study, it is demonstrated that MMP-9 serum as well as follicular concentrations are related to a successful IVF resulting in pregnancy. Currently, a limited number of studies have investigated intrafollicular and serum MMPs, with inconsistent conclusions. However, MMPs theoretically could be important players in IVF processes. Moreover, different behaviors of MMP-2 and MMP-9 during the embryo development were confirmed; only MMP-9 has shown a vast difference between follicular and maturation oocyts. The main objective of this study is to examine the mode of MMPs activation during bovine in vitro fertilization. In particular, the relative employment of two major embryo culture medium in embryo development; e.g. ES(non-bovine serum) and CR(bovine serum) was compared. This results found that the level of MMP-2 and MMP-9, which degrades basal membrane, was different in the ES and CR in cultured at each stage of embryo development. In ES cultured system, MMP-9 was highly expressed throughout blastocyst inner cell mass and exhibited strong gelatinase activity. The MMP-9 expression continually increased as the embryo develops from oocyte maturation to fertilization, Meanwhile, the level of MMP-2 remained insignificant throughout these periods. However, decreased MMP-2 and 9 expression on the CR culture system. Interestingly, MMP-9 was actively expressed in ES culture system, inner cell mass is showing levels higher than trophoblast cell. Our result suggests a possibility that different subtype of MMP partakes major functions in the remodeling of inner cell mass in blastocyst. Such differences in MMP expression may impact to the distinct mode of follicular development in the two species.
Reconsideration of Vigabatrin Effect in Infantile Spasms Treatment
Da Hye Yoon,Ja Un Moon,Joo Young Lee,In Goo Lee 대한소아신경학회 2019 대한소아신경학회지 Vol.27 No.2
Purpose: To investigate the effect of vigabatrin (VGB) as a therapeutic agent for patients with infantile spasms (IS), compare risk factors for treatment response, and review safety of VGB by assessing its side effects. Methods: Among 35 patients admitted to the Department of Pediatric Neurology, Seoul St. Mary s Hospital, College of Medicine, The Catholic University of Korea who received initial monotherapy with VGB under diagnosis of IS, 23 patients who met our inclusion criteria were enrolled and their medical records were retrospectively reviewed. Results: Of these 23 patients, average age at diagnosis was 7.26 ± 4.8 months and average age at spasms was 6.20 ± 3.8 months. Average treatment lag was 1.09 ± 1.8 months. Thirteen patients (56.5%) achieved seizure free status. There was no ophthalmic complication among patients. Remission of hypsarrhythmia at 3 and 6 months after treatment was a good prognostic factor (P=0.026 and P=0.004, respectively). Conclusion: VGB is effective enough to become a first-line drug for children with IS. Better prognosis can be expected in patients with clinical remission of hypsarrhythmia on electroencephalography after treatment initiation using VGB compared to those who do not have such remission. Regular eye examination and follow-up check-up are also needed in parallel with the use of VGB.
Yoon, Da Hye,Park, Yong Joon The Korean Electrochemical Society 2021 Journal of electrochemical science and technology Vol.12 No.1
The electrochemical performance of all-solid-state cells (ASSCs) based on sulfide electrolytes is critically affected by the undesirable interfacial reactions between oxide cathodes and sulfide electrolytes because of the high reactivity of sulfide electrolytes. Based on the concept that the interfacial reactions are highly dependent on the type of sulfide electrolyte, the electrochemical properties of the ASSCs prepared using three types of sulfide electrolytes were observed and compared. The Li2MoO4-LiI coating layer was also introduced to suppress the interfacial reactions. The cells using argyrodite electrolyte exhibited a higher capacity and Coulombic efficiency than the cells using 75Li2S-22P2S5-3Li2SO4 and Li7P3S11 electrolytes, indicating that the argyrodite electrolyte is less reactive with cathodes than other electrolytes. Moreover, the introduction of Li2MoO4-LiI coating on the cathode surface significantly enhanced the electrochemical performance of ASSCs because of the protection of coating layer. Pulverization of argyrodite electrolyte is also effective in increasing the capacity of cells because the smaller size of electrolyte particles improved the contact stability between the cathode and the sulfide electrolyte. The cyclic performance of cells was also enhanced by pulverized electrolyte, which is also associated with improved contact stability at the cathode/electrolyte. These results show that the introduction of Li2MoO4-LiI coating and the use of pulverized sulfide electrolyte can exhibit a synergic effect of suppressed interfacial reaction by the coating layer and improved contact stability owing to the small particle size of electrolyte.
Liver abscess due to Klebsiella pneumoniae in a healthy 12-year-old boy
Yoon, Da Hye,Jeon, Yeon Jin,Bae, E Young,Jeong, Dae Chul,Kang, Jin Han The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.11
Pyogenic liver abscess (PLA) is rare in healthy children. We report a case of PLA in an immunocompetent 12-year-old boy. Percutaneous catheter drainage was performed for the abscess. In addition, parenteral antibiotics were administered for 3 weeks. Klebsiella pneumoniae was detected in the culture of blood and drained fluid. Here, we present this case and a brief review of the literature on this subject.
Da-Hye Shin,Ji-Hye Lee,Sang-Hwan Kim,Ji-Yeon Kim,Jong-Taek Yoon 한국수정란이식학회 2017 한국수정란이식학회 학술대회 Vol.2017 No.05
The coat color of mammals is determined by the melanogenesis pathway, which is responsible for maintaining the balance between black-brown eumelanin and yellow-reddish pheomelanin. The melanogenesis-associated genes controlling pigmentation act as a complex and interact with each other to cause phenotypic and genotypic variations in cattle. That the MC1R genotype of Korean native cattle with dark muzzle was e/e or E+/e, while the genotype of Korean native cattle with light muzzle was E+/E+, which is a variant of the MC1R genotype in the Korean native cattle. Especially, the MC1R expression type is shows how much pigmentation, important factor in deciding its status in the coat and nose colours. However, information regarding the coat or nose colours-associated gene regulation of korean cattle is not yet unknown. Therefore, in this study was to investigate the expression patterns of melanogenesis-associated genes in black dot nose(korea brindle cattle) and normal nose(korea native cattle). Using microarray clustering and real-time polymerase chain reaction techniques, we analysed that the expression of genes involved in the mitogen-activated protein kinase (MAPK) and Wnt signaling pathways is distinctively regulated in the dark and light muzzle tissues. Differential expression of tyrosinase was also noticed, although the difference was not as distinct as those of MAPK and Wnt. We hypothesize that emphasis on the MAPK pathway in the Korea brindle cattle induces eumelanin synthesis through the activation of cAMP response elementbinding protein and tyrosinase, while activation of Wnt signaling counteracts this process and raises the amount of pheomelanin in the native cattle. Regarding the increasing interest in the genetic diversity of cattle stocks, genes we identified for differential expression in the brindle cattle vs. native cattle may serve as novel markers for genetic diversity among cows based on the coat and muzzle color phenotype.