http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Hyo Seon,Oh, Seung Ja,Lee, Kwang-Hoon,Lee, Yoon-Sook,Ko, Eun,Kim, Kyung Eun,Kim, Hyung-chan,Kim, Seokkyun,Song, Paul H.,Kim, Yong-In,Kim, Chungho,Han, Sangyeul American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.45
<P>Angiopoietin-2 (Ang-2) not only regulates angiogenesis by binding to its well known receptor Tie2 on endothelial cells but also controls sprouting of Tie2-negative angiogenic endothelial cells and invasion of Tie2-negative non-endothelial cells by binding to integrins. However, the molecular mechanism of the Ang-2/integrin association has been unclear. In this study, we found that the Gln-362 residue of Ang-2 was essential for binding to α5β1 integrin. A Q362E Ang-2 mutant, which still bound to Tie2, failed to associate with α5β1 integrin and was unable to activate the integrin downstream signaling of focal adhesion kinase. In addition, unlike wild-type Ang-2, the Q362E Ang-2 mutant was defective in mediating invasion of Tie2-negative glioma or Tie2-positive endothelial cells. Furthermore, the tailpiece domain of the α5 subunit in α5β1 integrin was critical for binding to Ang-2. Taken together, these results provide a novel insight into the mechanism of integrin regulation by Ang-2, which contributes to tumor invasion and endothelial cell migration in a Tie2-independent manner.</P>
Methods of Selecting Electroencephalographic Features for Personal Authentication
Chungho Lee,Jae-Hwan Kang,Sung-Phil Kim 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
Biometric technology based on electroencephalography (EEG) identifies individuals by using personal characteristics in human brainwaves. This study aims to evaluate EEG features and channels for biometrics and to propose a methodology that selects the optimal features to discriminate individuals. Thirty healthy subjects participated in the study. While recording EEG signals from fourteen channels, subjects were asked to relax and keep eyes closed for two minutes. To evaluate intra-individual variability, we recorded EEG ten times for each subject across different days to reduce any within-day effect. From each channel, eight EEG features were calculated including alpha/beta power ratio, alpha/theta power ratio, beta/theta power ratio, median frequency, PSD entropy, permutation entropy, sample entropy, and maximum Lyapunov exponents. These features were evaluated by three feature selection algorithms based on Fisher score, reliefF, and information gain, respectively. A linear discriminant analysis (LDA) classifier along with a leave-oneout cross validation method discriminated self against others using the selected features. The best feature set was found to be composed of 23 features highly ranked on Fisher scores, which yielded a 18.56% half total error rate. In addition, EEG channels located on occipital and right temporal areas appeared to most contribute to authenticate individuals.
Kim, Chungho,Seon Lee, Hyo,Lee, Deokjae,Lee, Sang Don,Cho, Eun-Gyung,Yang, Soo Jung,Kim, Sang Bum,Park, Dongeun,Kim, Moon Gyo American Society of Hematology 2011 Blood Vol.117 No.4
<B>Abstract</B><P>Epithin/PRSS14, a type II transmembrane serine protease, is involved in normal epithelial development and tumor progression. Here we report, as an interacting substrate of epithin, a receptor tyrosine kinase Tie2 that is well known for important roles in the vessel stability. Epithin interacts with and degrades the Tie2 extracellular portion that contains the ligand-binding domain. Epithin is located in the neighbor of Tie2-expressing vessels in normal tissue. Furthermore, epithin can cleave and degrade Tie2 not only in the same cell but also from neighboring cells nearby, resulting in the degradation of the Tie2 ectodomain. The remaining Tie2 fragment was highly phosphorylated and was able to recruit a downstream effector, phosphatidylinositol 3-kinase. Knocking down epithin expression using short hairpin RNA in thymoma cell severely impaired the migration through endothelial cells that show the actin rearrangement during the process. The diminution of epithin protein expression in 4T1 breast cancer cells caused the significant decrease in the number of transendothelial migrating cells in vitro as well as in those of metastasizing tumor nodules in vivo, Therefore, we propose that epithin, which regulates endothelial Tie2 functions, plays a critical role in the fine tuning of transendothelial migration for normal and cancer cells.</P>
Sangkeum Lee,Sarvar Hussain Nengroo,Hojun Jin,Yoonmee Doh,Chungho Lee,Taewook Heo,Dongsoo Har Electronics and Telecommunications Research Instit 2023 ETRI Journal Vol.45 No.4
A novel smart metering technique capable of anomaly detection was proposed for real-time home power management system. Smart meter data generated in real-time were obtained from 900 households of single apartments. To detect outliers and missing values in smart meter data, a deep learning model, the autoencoder, consisting of a graph convolutional network and bidirectional long short-term memory network, was applied to the smart metering technique. Power management based on the smart metering technique was executed by multi-objective optimization in the presence of a battery storage system and an electric vehicle. The results of the power management employing the proposed smart metering technique indicate a reduction in electricity cost and amount of power supplied by the grid compared to the results of power management without anomaly detection.