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RISS 인기검색어
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- 저자 : Chuang Yao-Chung (검색결과 3 건)
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Yeh Nan-Ching,Chuang Yao-Chung,Peng Hsin-Shuo,Hsu Kuo-Lin 한국기상학회 2020 Asia-Pacific Journal of Atmospheric Sciences Vol.56 No.3
The Global Satellite Mapping of Precipitation (GSMaP) was used to estimate the accumulated rainfall in May from the Mei-Yu front in Taiwan. Rainfall estimation from GSMaP during 2002–2017 were evaluated using more than 400 local gauge observations, collected from the Taiwan CentralWeather Bureau (CWB). Studies have demonstrated that the GSMaP rainfall estimation estimates can be biased, depending on the target region, elevation, and season. In this experiment, we have evaluated GSMaP over three elevation ranges. The GSMaP systemic errors for each elevation range were identified and corrected using regression analysis. The results indicated that GSMaP estimation can be improved significantly through adjustment over three elevation ranges (elevation less than 50 m, elevation of 50–100 m, and elevation higher than 100 m). For these three elevation ranges, the correlation coefficient between the GSMaP estimations and CWB rainfall data was 0.76, 0.78, and 0.59, respectively. This indicated that the GSMaP estimation was more accurate for low-elevation regions than high-elevation regions. After the proposed approaches were employed to correct the errors, the bias errors were respectively improved by 5.64(13.7%), 7.33(38.4%) and 10.52(31.2%)mmfor low-, mid- and high-elevation regions. This study demonstrated that the local correction approaches can be used to improve GSMaP estimation of Mei-Yu rainfall in Taiwan.
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( Shih-wen Hsu ),( Chien-yio Lin ),( Chuang-wei Wang ),( Wen-hung Chung ),( Chih-hsun Yang ),( Yao-yu Chang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
We studied a family with Gorlin-Goltz syndrome. The novel mutations of our cases were located on the 21st exon of the PTCH1 gene (c.3450C>G). The father, who received a strategic 56-day vismodegib treatment for disease control, was the first patient with Gorlin syndrome treated with the hedgehog inhibitor in Taiwan. The lesions regressed gradually, with scar formation, and were subsequently removed via a wide excision. Further details are provided below. (Ann Dermatol 30(5) 597∼601, 2018)
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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
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