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RISS 인기검색어
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- 저자 : Chirag Ahuja (검색결과 4 건)
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Episodes of prolonged “trance-like state” in an infant with hypothalamic hamartoma
Rakesh Kumar,Jaivinder Yadav,Jitendra Kumar Sahu,Manjul Tripathi,Chirag Ahuja,Devi Dayal 대한소아내분비학회 2019 Annals of Pediatirc Endocrinology & Metabolism Vol.24 No.1
Hypothalamic hamartoma (HH) is one of the most common causes of central precocious puberty (CPP) in first few years of life. It can present with either seizures or CPP, although both manifestations coexist in the majority of the children. Gelastic seizures (GS), or laughing spells, are usually the first type of seizures seen in patients with HH. Although a wide variety of seizure types are known to occur in children with HH, GS are most common and consistent seizure type. The clinical presentation of HH may vary with the size and position of the mass, although large tumours typically present with both CPP and seizures. Although CPP can be managed with medical therapy, seizures can be very difficult to treat, even with multiple antiepileptic drugs. Noninvasive gamma knife surgery has been used with some success for the treatment of refractory epilepsy. We present a case of HH with very early onset seizures and CPP. The patient had an atypical form of seizures described by the parents as a "trance-like state" in which the patient had prolonged episodes of unresponsiveness lasting for hours with normal feedings during the episodes. GS occurred late in the course and were refractory to various combinations of antiepileptic drugs. A brain magnetic resonance imaging showed a large sessile HH (>20 mm). Later in the course of the disease, the patient experienced cognitive and behavioural problems. The patient underwent gamma knife surgery at nearly 5 years of age and experienced a modest response in seizure frequency. This case highlights the presentation of HH as a previously unreported seizure morphology described as a prolonged "trance-like state."
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Clinical behaviour and outcome in pediatric glioblastoma: current scenario
Aditya Kumar Singla,Renu Madan,Kirti Gupta,Shikha Goyal,Narendra Kumar,Sushant Kumar Sahoo,Deepak K. Uppal,Chirag K. Ahuja 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1
Pediatric glioblastoma (pGBM) is a rare entity accounting for only approximately 3% of all childhood brain tumors. Treatment guidelines for pGBM have been extrapolated from those in adult glioblastoma. Rarity of pGBM and underrepresentation of pediatric population in major studies precludes from defining the ideal treatment protocol for these patients. Maximum safe resection is performed in most of the cases followed by postoperative radiotherapy in children over 3 years of age. Benefit of temozolomide is unclear in these patients. Here, we present the clinicopathological details and outcome of six pGBM patients treated at our institute in 2018–2019.
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The Diagnostic Dilemma of Neurolymphomatosis
Ritu Shree,Manoj Kumar Goyal,Manish Modi,Balan Louis Gaspar,Bishan Dass Radotra,Chirag Kamal Ahuja,Bhagwant Rai Mittal,Gaurav Prakash 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.3
Neurolymphomatosis (NL) defned as infltration of the central nervous system or the peripheral nervous system (PNS) by malignant lymphoma cells is a rare clinical entity. However, the increasing use of fuorodeoxyglucose positron-emission tomography (FDG-PET) and magnetic resonance imaging in evaluating PNS disorders is resulting in; this condition being recognized more frequently. Here; we report fve NL patients and review the current literature. We report five patients with non-Hodgkin’s lymphoma (NHL) and NL, all of whom were men aged 47–69 years. Te clinical presentation varied from symmetrical peripheral neuropathy to mononeuropathy. Peripheral neuropathy was the presenting manifestation of a systemic lymphoma in two patients (40%). Neuroimaging as well as whole-body FDG-PET helped in determining the correct diagnosis in all of the patients. NL is an unusual presentation of NHL resulting from infltration of the PNS by malignant lymphomatous cells. While evaluating peripheral neuropathy, a high degree of suspicion of NL is required since the presenting symptoms vary, conventional radiology has only modest sensitivity, and a pathological diagnosis is ofen difcult. FDG-PET helps in the early diagnosis and treatment of this condition.
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Recent progress and growth in biosensors technology: A critical review
Utkarsh Chadha,Preetam Bhardwaj,Rushali Agarwal,Priyanshi Rawat,Rishika Agarwal,Ishi Gupta,Mahek Panjwani,Shambhavi Singh,Chirag Ahuja,Senthil Kumaran Selvaraj,Murali Banavoth,Prashant Sonar,Badrish B 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
Crucial exploitation of biosensors has attained dominant significance in the meadow of drug innovation,drug identification, bio-remedy, food protection principles, security, protection, and ecological examination. It has direct to the innovation of specific and authoritative diagnostic tools that employ biologicalsensing elements as biosensors. Glucometers employ oxygen or hydrogen peroxide electrochemicalrecognition utilizing immobilized glucose oxidase electrodes, showing biosensors’ invention. Currentadvances in biological methods and instrumentation relating to fluorescence tags to nano-materials haveincreased the responsive limit of biosensors. The use of aptamers or nucleotides, antibodies, peptidearrays, and molecule imprinted polymers offer tools to build up novel biosensors over the classicalmethod. Integrated methods offer an improved perception for a buildup of precise and responsive biosensorswith high regenerative potentials. Various biosensors ranging from nanomaterials polymers tomicrobes have more comprehensive potential applications. Combining multifaceted approaches to designbiosensors that comprise the prospective for different usage is reasonably significant. In light of this, thisreview provides an overview of different types of biosensors being used, ranging from electrochemicaland fluorescence tagged, nanomaterials, silica or quartz, and microbes for various biomedical and environmentalapplications with the future outlook of biosensor technology.
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