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산악지형에서의 UHF대역 전파손실예측을 위한 LEE모델 적용방안 연구
이창원,전용찬,신임섭,김진국,Lee, Changwon,Jeon, Yongchan,Shin, Imseob,Kim, Jin-Goog 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.2
In this paper, we have compared some radio propagation models in order to verify the performance of W.C.Y LEE propagation model in mountain area. The four propagation models, which are Okumura-Hata, ITU-R P.525, Egli and W.C.Y. LEE, are analyzed by comparing the differences between measured values and propagation loss estimation values. And a correction method for W.C.Y LEE model is suggested to improve the performance of W.C.Y. LEE model with measured data in mountain area. Simulation results show that the estimation error using W.C.Y LEE model is the lowest among four propagation models. Also, the results show that the corrected W.C.Y LEE model with suggested method improves the performance of propagation loss estimation.
ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase
Lee, Yejin,Lim, Byungho,Lee, Seon Woo,Lee, Woo Rin,Kim, Yong-In,Kim, Minhyeok,Ju, Hyoungseok,Kim, Mi Young,Kang, Suk-Jo,Song, Ji-Joon,Lee, J. Eugene,Kang, Changwon Elsevier 2018 Biochimica et biophysica acta. Molecular basis of Vol.1864 No.10
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Human <I>ANKRD9</I> (ankyrin repeat domain 9) expression is altered in some cancers.</P> <P><B>Methods</B></P> <P>We tested genetic association of ANKRD9 with gastric cancer susceptibility and examined functional association of ANKRD9 with altered proliferation of MKN45 gastric cancer cells. We then identified ANKRD9-binding partners in HEK 293 embryonic kidney cells using quantitative proteomics, western blotting and complex reconstitution assays. We finally demonstrated ANKRD9's role of recognizing substrates for ubiquitination using in vitro ubiquitylation assay.</P> <P><B>Results</B></P> <P> <I>ANKRD9</I> is associated with cancer susceptibility in a comparison of single-nucleotide polymorphisms between 1092 gastric cancer patients and 1206 healthy controls. ANKRD9 depletion accelerates tumor progression by increasing cellular proliferation, piling up, and anchorage-independent growth of MKN45 cells. We discovered that ANKRD9 is a ubiquitin ligase substrate receptor subunit and has an anti-proliferative activity. ANKRD9 associates with CUL5 (not CUL2), ELOB, ELOC, and presumably RNF7 subunits, which together assemble into a cullin-RING superfamily E3 ligase complex. ANKRD9 belongs to the ASB family of proteins, which are characterized by the presence of ankyrin repeats and a SOCS box. In addition to its interactions with the other E3 ligase subunits, ANKRD9 interacts with two isoforms of inosine monophosphate dehydrogenase (IMPDH). These IMPDH isoforms are cognate substrates of the ANKRD9-containing E3 enzyme, which ubiquitinates them for proteasomal degradation. Their ubiquitination and turnover require the presence of ANKRD9.</P> <P><B>Conclusion</B></P> <P>ANKRD9, a previously unidentified E3 substrate receptor subunit, functions in tumor suppression by recognizing the oncoprotein IMPDH isoforms for E3 ubiquitination and proteasomal degradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Human <I>ANKRD9</I> is genetically associated with gastric cancer susceptibility. </LI> <LI> ANKRD9 protein activity is functionally associated with tumor suppression. </LI> <LI> ANKRD9 is a substrate receptor subunit of CUL5-based ubiquitin ligase E3 complex. </LI> <LI> E3 with ANKRD9 ubiquitinates substrate proteins for proteasomal degradation. </LI> <LI> Two isoforms of oncoprotein IMP dehydrogenase are cognate substrates of ANKRD9. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Accurate quantification of transcriptome from RNA-Seq data by effective length normalization
Lee, Soohyun,Seo, Chae Hwa,Lim, Byungho,Yang, Jin Ok,Oh, Jeongsu,Kim, Minjin,Lee, Sooncheol,Lee, Byungwook,Kang, Changwon,Lee, Sanghyuk Oxford University Press 2011 Nucleic acids research Vol.39 No.2
<P>We propose a novel, efficient and intuitive approach of estimating mRNA abundances from the whole transcriptome shotgun sequencing (RNA-Seq) data. Our method, NEUMA (Normalization by Expected Uniquely Mappable Area), is based on effective length normalization using uniquely mappable areas of gene and mRNA isoform models. Using the known transcriptome sequence model such as RefSeq, NEUMA pre-computes the numbers of all possible gene-wise and isoform-wise informative reads: the former being sequences mapped to all mRNA isoforms of a single gene exclusively and the latter uniquely mapped to a single mRNA isoform. The results are used to estimate the effective length of genes and transcripts, taking experimental distributions of fragment size into consideration. Quantitative RT–PCR based on 27 randomly selected genes in two human cell lines and computer simulation experiments demonstrated superior accuracy of NEUMA over other recently developed methods. NEUMA covers a large proportion of genes and mRNA isoforms and offers a measure of consistency (‘consistency coefficient’) for each gene between an independently measured gene-wise level and the sum of the isoform levels. NEUMA is applicable to both paired-end and single-end RNA-Seq data. We propose that NEUMA could make a standard method in quantifying gene transcript levels from RNA-Seq data.</P>
Additive light field displays : realization of augmented reality with holographic optical elements
Lee, Seungjae,Jang, Changwon,Moon, Seokil,Cho, Jaebum,Lee, Byoungho Association for Computing Machinery 2016 ACM transactions on graphics Vol.35 No.4
<P>We propose a see-through additive light field display as a novel type of compressive light field display. We utilize holographic optical elements (HOEs) as transparent additive layers. The HOE layers are almost free from diffraction unlike spatial light modulator layers, which makes this additive light field display more advantageous when modifying the number of layers, thickness, and pixel density compared with conventional compressive displays. Meanwhile, the additive light field display maintains advantages of compressive light field displays. The proposed additive light field display shows bright and full-color volumetric images in high definition. In addition, users can view real-world scenes beyond the displays. Hence, we expect that our method can contribute to the realization of augmented reality. Here, we describe implementation of a prototype additive light field display with two additive layers, evaluate the performance of transparent HOE layers, describe several results of display experiments, discuss the diffraction effect of spatial light modulators, and analyze the ability of the additive light field display to express uncorrelated light fields.</P>
Lee, Seungjae,Jang, Changwon,Cho, Jaebum,Yeom, Jiwoon,Jeong, Jinsoo,Lee, Byoungho The Optical Society 2016 Applied optics Vol.55 No.3
<P>Holographic-optical-element (HOE)-based integral imaging display can be applied to augmented reality. However, a narrow viewing angle is a bottleneck for commercialization. Here, we propose a method to enhance the viewing angle of the integral imaging display using Bragg mismatched reconstruction of HOEs. The viewing angle of the integral imaging display can be enlarged with two probe waves, which form two different viewing zones. The effect of Bragg mismatched reconstruction is analyzed with simulation and experiment. In order to show feasibility of the proposed method, a display experiment is demonstrated. (C) 2015 Optical Society of America</P>