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산란계에 투여된 플루오로퀴놀론계 합성항균제의 계란내 이행 잔류 연구
서계원,이재일,이채용,김은선,이정치 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.4
In the past few years the use of four fluoroquinolones such as of ofloxacin(OF), norfloxacin(NORE), ciprofloxacin(CIP), enrofloxacin(ENR) in veterinary practice has increased. The aim of this study was to determine the elimination of fluoroquinolones into eggs, by intramuscular injection of laying hens(2.5mg of ENR/kg, 5mg of CIP/kg, 5mg of NOR/kg, 5mg of OF/kg). The treatment of fluoroquinolones was carried out in 3 stages with 9 laying hens (Isabrown), with mean weight 1.8kg, which were housed in individual cages. Four fluoroquinolones were administered to 9 laying hens through intramuscular injection at 1 day, 2 days, 5 days trial respectively. Sample (Albumen, Yolk, Whole egg) were analysed by high performance liquid chromatography (HPLC) with a fluorescence programmable detector and matrix solid phase despersion (MSPD) extraction. Residues of fluoroquinolones were much higher in the yolk than in the albumen. Detectable residues persisted for 12 days, 14 days, 16 days, respectively, in albumen and yolk after the injection was discontinued. The increase of the fluoroquinolones concentration in yolk was very rapid and reached a plateau after 3 days of dosing. In albumen, the fluoroquinolones concentration increased during intramuscular injection. As soon as the injection was discontinued, residues decreased in the albumen and the yolk.
MSPD법과 HPLC를 이용한 계란내 플루오로퀴놀론계 항균물질의 동시 다성분 정량분석
서계원,이재일,이채용,김은선,이정치 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.4
A multi-residue matrix solid-phase dispersion extraction and the liquid chromatographic determination of enrofloxacin, ciprofloxacin, norfloxacin and ofloxacin in eggs is described. Blank and fluoroquinolones fortified egg samples (0.5 g) containing oxalic acid 0.05 g and sodium sulfate (anhydrose) 0.5 g were blended with octadecylsilyl (C_(18), 40 m, 18% load, endcapped, 2 g) derived from silica. After homogenization, C_(18)/egg matrix was transferred to column made of 10 ml plastic syringe and filter paper, and compressed 4.0 4.5 ml volume. A column was washed with 8 ml of hexane followed by 8 ml of ethylacetate and dried under N2 gas. Fluoroquinolones were eluated with 8 ml of methanol under gravity. The eluate contained fluoroquinolones, was free from interferences when analyzed by high performance liquid chromatography with fluorescence detection. Correlation coefficients for the fluoroquinolones standard curves (linear regression analysis, n = 5) ranged from 0.99918 (± 0.0035) to 0.99985 (± 0.0002). Aveage recoveries of fortified samples were between 89.4 and 103.5%. The method comparared favorably with the classical method in terms of the sample size, analysis time and overalls costs.
Seo, M.,Oh, C.S.,Chai, J.-Y.,Jeong, M.S.,Hong, S.W.,Seo, Y.-M.,Shin, D.H. JOURNAL OF PARASITOLOGY 2014 The Journal of parasitology Vol.100 No.1
In the coprolites of 4 recently discovered Joseon mummies of Korea, we found Ascaris lumbricoides, Trichuris trichiura, Metagonimus yokogawai, Paragonimus westermani, and Clonorchis sinensis eggs. The current finding was compared with previous paleoparasitological data, and with recent national survey data from Korea. For A. lumbricoides and T. trichiura, similar patterns of infection prevalence were observed between the national survey of 1961 and our current Joseon data. Some of the trematode species (C.sinenesis and P. westermani) showed much higher infection prevalences among the Joseon Koreans than among their 1960s descendants. The present results indicate that the decrease in trematode infection rates might have begun earlier than was the case for nematode infection.
서윤희(Yun Hui Seo),정채빈(Chai Bin Jeong),서명효(Myoung Hyo Seo),서종훈(Jong Hun Seo),유호달(Ho Dal Yu),필감매(Chien Mei Pi),이기남(Ki Nam Lee) 대한의료기공학회 2007 醫療氣功 Vol.10 No.1
The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers’ daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don’t have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don’t have case history, and HF was high when they don’t have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don’t affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.
Association between Perceived Parenting Style and Adolescents’ Attitudes toward Suicide
Seo-Hyun Choi,Sang-Eun Lee,Chai Won Lee,Seri Maeng,Jisung Son,Won-Hyoung Kim,Jae Nam Bae,Jeong Seop Lee,Hyeyoung Kim 대한소아청소년정신의학회 2020 소아청소년정신의학 Vol.31 No.4
Objectives: Adolescent suicide, a major cause of adolescent death, is affected by various factors, including attitudes toward suicide. This study investigated the association between parenting style and adolescents’ attitudes toward suicide and the mediating role of attitude toward suicide between parenting style and suicidal ideation. Methods: We surveyed 1,071 adolescents from eight middle schools in Incheon, Korea. The survey included sociodemographic information, attitudes toward suicide, perception of parenting style, depression severity, and suicidality. Results: Students in the authoritarian parenting group had a more permissive attitude toward suicide compared with the democratic and permissive parenting groups. These students considered that suicide is justified in certain situations and that choosing suicide is an individual’s right. They also had a negative attitude toward talking about suicide or intervening in others’ suicide. This association remained statistically significant after adjusting for the impact of confounding factors that could affect attitudes toward suicide, except for suicidal processes and preparedness to prevent suicide. In the mediation analysis, we observed that some factors of the attitudes toward suicide mediated between authoritarian parenting attitudes and suicidal ideation, namely, suicide as a right, preventability, suicide as normal/common, preparedness to prevent suicide, and resignation. Conclusion: This study revealed the significant impact of parenting style on children’s attitudes toward suicide. Educating parents about the appropriate parenting attitudes–sympathetic and rational–can help prevent youth suicide.
國産 Praziquantel (Cestocide^(�)의 無鉤條蟲 및 廣節裂頭條蟲에 對한 治療效果
蔡鐘一,孫運睦,洪性琮,李純炯,徐丙卨 대한화학요법학회 1985 대한화학요법학회지 Vol.3 No.2
Praziquantel(Cestocide^ⓡ), Korean product, was tested for its efficacy in the treatment of Taenia saginata and Diphylobothrium latum infection during the period from May 1983 to October 1985, A total of 30 patients were treated with 10~30㎎/㎏ single dose of praziquantel and purged with 20~30g of magnesium sulfate to recover the worms. The results were as follows: 1. The patients were 26 cases of T. saginata and 4 cases of D. latum and after the treatment all of them discharged tapeworm segments with or without their scolices. The scolex recovery rate was 43.3%(from 11 and 2 cases of T. saginata and D. Iatum respectively). 2. The follow[up examination for eggs and/or proglottides performed 2~3 months later or 11 out of 17 scolex-unidentified cases gave all negative results. From the results it is concluded that praziquantel(Cestocide^ⓡ) in 10㎎/㎏ single dose is highly effective in treatment of these tapeworm infections.
5-(4-Hydroxyphenethenyl)-4,7-dime-thoxycoumarin, a New Constituent of Monotes engleri
Seo, Eun-Kyoung,Chai, Hee-Byung,Chagwedera, Tangai E.,Farnsworth, Norman R.,Cordell, Geoffrey A.,Pezzuto, John M.,Kinghorn, A. Douglas 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.
Metallo-Pc 촉매에 의한 휘발성 유기화합물의 촉매산화
서성규,김상채,윤형선 여수대학교 1997 論文集 Vol.11 No.2
Catalytic oxidation of methanol as a volatile organic compound(VOC) was studied at atmospheric pressure in a fixed bed flow reactor system over metallo-Pc catalysts. The activity of these catalyst in terms of metal ion, pretreatment gas, reaction temperature, contact time was studied. The experiment was conducted at the reaction temperature of 200~350℃, CH₃OH in air of 2.29 mole%, the contact time of 0.31~3.73gㆍcat-hr/gㆍmol-feed. As a result of study, pretreatment with air and methanol mixture showed the best performance for catalytic activity. The increasing order of catalytic activites for methanol conversion to carbon dioxide and water was as follows : metal free-Pc < Zn-Pc < Fe-Pc < Cu(α)-Pc < Cu(β)-Pc < Co-Pc. The catalytic activity of Co-Pc catalyst was very good at low temperature. And, Co-Pc catalyst had many possibilities as an alternative catalyst for the expensive commercial oxidation catalyst.