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- 저자 : Can Qin (검색결과 6 건)
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Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma
Can Cao,Chao Zhang,Ying Sun,Zhen Mu,Qin Shen 한국유전학회 2021 Genes & Genomics Vol.43 No.4
Background Myosin18 family, including Myosin18A (MYO18A) and Myosin18B (MYO18B), are newly-identifed Myosins in Myosin superfamily. The expression and function of Myosin18 family in cancer progression is still controversial, and in cutaneous squamous-cell carcinoma (cSCC) is totally unknown. Objective To investigate the expression and prognostic signifcance of Myosin18 family in cSCC. Methods In this study, the expressions of MYO18 family, including MYO18A and MYO18B were detected in six pairs of cSCCs and corresponding normal tissues with qRT-PCR. MYO18A and MYO18B expressions and intracellular locations in 80 cSCCs were detected with immunohistochemistry. The clinical signifcance was evaluated by analyzing the correlation between MYO18 family and clinicopathological factors. The prognostic signifcance of MYO18 family was estimated by univariate analysis with log-rank test, and by multivariate analysis by Cox-regression model. Results The percentages of high MYO18A and MYO18B in cSCC were 43.75% and 36.25%, respectively. High expression of MYO18A (P=0.035) and MYO18B (P=0.032) were both associated with less tumor size. MYO18A had no signifcant infuence on sSCC prognosis (P=0.686), but low expression of MYO18B was proved to be signifcantly associated with poor outcome of cSCC (P=0.014). MYO18B was confrmed as an independent prognostic biomarker of cSCC (P=0.002), indicating the favorable outcome. Conclusion The expression of MYO18B was an independent prognostic biomarker of cSCC, predicting the favorable prognosis independently. Investigating the expression of MYO18B can help stratify the subset of high-risk cSCC patients for more potent treatment and post-operational surveillance.
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Physical Characteristics of Lighting Environment and Physiological Change of Drivers in Tunnel
Can Qin,Bo Liang,Jinghang Xiao,Jia’an Niu,Shiyong He 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5
The physical characteristics (i.e., road surface luminance, sidewall luminance, overall uniformity of luminance, and longitudinal uniformity of luminance) of the tunnel and the physiological change (i.e., pupil diameter and heart rate) of the drivers were investigated by the real vehicle tests and the whole scale model. Experiments were carried out in the real tunnel and the whole scale model with the sidewalls covered by the energy-storage and self-luminous material coating (ESMC) and the fireproof material coating (FMC). The results also show that compared to FMC, the luminance and the luminance uniformity were higher, and the pupil diameter and heart rate of drivers were smaller for ESMC. Furthermore, the physical characteristics of the light environment are negatively correlated with the physiological change of drivers. Moreover, each decrease of 1 cd/mm2 in road surface luminance and sidewall luminance, the pupil diameter increase by 0.54 and 1.06 mm, the heart rate increase 7.29 and 14.15 times/min, respectively. Each decrease of 0.1 in luminance uniformity, the pupil diameter increase by 0.33 mm, the mean heart rate increase 4.41 times/min, respectively.
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Hybrid Method of Polygonal and Quadrilateral Elements for Modeling Jointed Rock Mass
Shuchen Li,Qin Yan,Zhaoqing Wang,Can Xie 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.7
In the numerical simulation of heterogeneous materials, such as jointed rock mass, it is extremely difficult to perform meshing forconstricted regions, resulting in time-consuming modeling and inaccurate computations. To this end, this paper presents a hybridmethod of polygonal and quadrilateral elements based on the finite element method. The function of barycentric rationalinterpolation from the mean value principle is introduced and the shape function of the polygonal element is established. Thepolygonal element can be directly used for meshing constricted regions of the heterogeneous material. Moreover, it avoids thesingular matrix and time-consuming meshing due to the particular geometry of this region. The coupling process of the polygonalelement and quadrilateral element is demonstrated. The proposed hybrid method was implemented in several benchmarks examplesto demonstrate its accuracy and capabilities. Quantitative comparisons of the numerical method and analytical solutions showedgood approximation. The proposed hybrid method has advantages of improved preprocessing efficiency, simple implementation,high accuracy, and robustness compared with the conventional finite element method. In addition, this method is significant for thenumerical modeling of complex geometries and provides a better solution for heterogeneous materials in engineering practice.
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Jun Hu,Can Tao,Aining Yuan,Junjie Bao,Qin Cheng,Gewen Xu,Yiping Huang 한국고분자학회 2019 폴리머 Vol.43 No.2
Series of waterborne polyurethanes (WPUs) containing poly(tetra methylene glycol) (PTMG), 4,4-dicyclohexylmethane diisocyanate (HMDI), 2,2-dimethylolpropionic acid (DMPA), 2,2,4-trimethyl-1,3-pentanediol (TMPD), isosorbide (ISO) and ethylenediamine (EDA) were synthesized. The effects of ISO on the structure and properties of WPUs were studied by gel permeation chromatography (GPC), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analyzer (DMTA), X-ray diffraction (XRD), thermogravimetry (TG), mechanical test, chemical resistance and hardness test. The deconvolution analysis of FTIR of WPUs revealed that the hydrogen bond interaction in the WPUs increased with the increase of ISO content. Furthermore, the degree of microphase separation was increased with the increase of hydrogen bond interaction, which was confirmed by DSC, XRD and DMTA test. The results demonstrated that the addition of ISO can increase the hydrogen bond interaction between the hard and hard segments in WPUs, which improved the mechanical properties of the WPU films. The highest tensile strength was obtained of 59.67 MPa when the content of isosorbide was 10.35 wt%. Moreover, the ISO was helpful to improve the chemical resistance and hardness of the coatings by the comprehensive performance analysis.
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Feng, Tao,Liu, Neng,Wang, Shunjie,Qin, Can,Shi, Shengwei,Zeng, Xueying,Liu, Gang Techno-Press 2021 Advances in nano research Vol.10 No.6
This review highlights and categorizes the approaches for preparation of CNTs dispersion and polymer/CNTs composites via solution-based strategies. Carbon nanotubes (CNTs) demonstrate unique physical and chemical properties, which allow several exciting potential applications in various fields including nanocomposites. Presently, the commercialized application of CNTs is still quite limited due to the formation of CNTs bundles, which significantly degrade the properties. Therefore, well dispersion of CNTs in nanocomposites is quite important, especially for CNTs/polymer composites, as a small amount of CNTs can improve the composite properties dramatically. This article will review the research on the dispersion of CNTs (including covalent and non-covalent functionalization) and the fabrication of CNTs/polymer composites through solution-based strategies by using the CNT dispersions. Moreover, the factors influencing the properties of CNTs/polymer composites will be discussed as well as the future outlook.
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Absence of EZH2 Gene Mutation in Chronic Myeloid Leukemia Patients in Blast Crisis
Chen, Hao-Yue,Yao, Hong,Wu, Ling-Yu,Liu, Can-Jun,Zhu, Jian-Qin,Liu, Chun-Hua,Wang, Wei,Dong, Sha-Sha,Ping, Na-Na,Chen, Su-Ning,Sun, Miao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
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