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      • Potential of Chanos chanos (Milklish) Skin Gel Extract as an Alternative Approach in Treating First Degree Burn

        Brian Kenneth E. Eduarte,Nicole Andrey Acosta,Jenela Pauline Lumanlan,Jhevia E. agnampo,Diana Rose Medrano,Kaori Ann B. Vicente,James Patrick C. Picar ASCONS 2019 IJBSA Vol.1 No.1

        Background/Objectives: The fire related injuries such as burns are one of the main problems of the community. It is because of the insufficient ideas in wound healing and lack of financial capabilities resulting into self-medication. Methods/Statistical analysis: In this study, the researchers will prepare an ointment from milkfish skin and scale added to soft paraffin in 70 C until it congeals. The milkfish is known having high content of riboflavin and vitamin B complex that is a big impact to fasten the first-degree burn healing process. The milkfish skin and scales are also to be extracted using Gamma Irradiation as a manner of sterilization and for preservation of collagen and vitamin B content. The experimental rats will be induced of burn wounds by 5 seconds in the back part using cylindrical heat steel to be associated in 100C boiling water which will be treated with the prepared ointment. The epithelialization times, wound contraction and histological examination will be observed and the data recorded is to be analyzed using one-way ANOVA and repeated measures. Findings: This study deals with scientific experimentation to identify the potential of Milkfish skin and scale in wound healing. Improvements/Applications: If proven effective, it may be utilized as an alternative wound healing agent.

      • Institutional Arrangements for Rural Poverty Reduction and Hunger Eradication in Uganda: An Empirical Analysis

        ( Rose B Namara ),( Benon C Basheka ) 한국정책학회 2012 International Journal of Policy Studies Vol.3 No.2

        Poverty reduction has been an overarching and universal goal for global and local development agendas. Global leaders chose to combine eradicating extreme poverty and hunger in the first Millennium Development Goal under the assumption that institutional arrangements to reduce poverty would automatically reduce hunger. Further assumptions suggested that all governments would design poverty reduction policies consistent with food security outcomes. We argue that concurrent hunger and poverty eradication in the rural settings of Uganda need direct institutional arrangements and action to reduce hunger as well as mechanisms that address other contextual factors. We empirically confirm that there are diverse determinants of hunger in Uganda with an associated socio-economic and political context. There is a relationship between poverty and hunger; therefore, government policies intended to address poverty need to embark on a synergy that coordinates interventions to address the interrelated societal problems of poverty and hunger.

      • SCOPUS

        Differences in UV transparency and thermal structure between alpine and subalpine lakes: implications for organisms

        Rose, Kevin C.,Williamson, Craig E.,Saros, Jasmine E.,Sommaruga, Ruben,Fischer, Janet M. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.9

        Ultraviolet (UV) radiation is a globally important abiotic factor influencing ecosystem structure and function in multiple ways. While UV radiation can be damaging to most organisms, several factors act to reduce UV exposure of organisms in aquatic ecosystems, the most important of which is dissolved organic carbon (DOC). In alpine lakes, very low concentrations of DOC and a thinner atmosphere lead to unusually high UV exposure levels. These high UV levels combine with low temperatures to provide a fundamentally different vertical structure to alpine lake ecosystems in comparison to most lowland lakes. Here, we discuss the importance of water temperature and UV transparency in structuring alpine lake ecosystems and the consequences for aquatic organisms that inhabit them. We present transparency data on a global data set of alpine lakes and nearby analogous subalpine lakes for comparison. We also present seasonal transparency data on a suite of alpine and subalpine lakes that demonstrate important differences in UV and photosynthetically active radiation (PAR, 400-700 nm) transparency patterns even within a single region. These data are used to explore factors regulating transparency in alpine lakes, to discuss implications of future environmental change on the structure and function of alpine lakes, and ways in which the UV transparency of these lakes can be used as a sentinel of environmental change.

      • KCI등재

        A Feasibility Study of Guided Wave Technique for Rail Monitoring

        Rose, J.L.,Lee, C.M.,Cho, Y. The Korean Society for Nondestructive Testing 2006 한국비파괴검사학회지 Vol.26 No.6

        The critical subject of transverse crack detection in a rail head is treated in this paper. Conventional bulk wave ultrasonic techniques oftenfail because of shelling and other surface imperfections that shield the defects that lie below the shelling. A guided wave inspection technique is introduced here that can send ultrasonic energy along the rail under the shelling with a capability of finding the deleterious transverse crack defects. Dispersion curves are generated via a semi analytical finite element technique along with a hybrid guided wave finite element technique to explore the most suitable modes and frequencies for finding these defects. Sensor design and experimental feasibility experiments are also reported.

      • Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

        Lin, C.,Yang, L.,Tanasa, B.,Hutt, K.,Ju, B.g.,Ohgi, K.A.,Zhang, J.,Rose, D.W.,Fu, X.D.,Glass, C.K.,Rosenfeld, M.G. Cell Press ; MIT Press 2009 Cell Vol.139 No.6

        Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By establishing a cellular model that mimics the relative frequency of authentic translocation events without proliferation selection, we report mechanisms of nuclear receptor-dependent tumor translocations. Intronic binding of liganded androgen receptor (AR) first juxtaposes translocation loci by triggering intra- and interchromosomal interactions. AR then promotes site-specific DNA double-stranded breaks (DSBs) at translocation loci by recruiting two types of enzymatic activities induced by genotoxic stress and liganded AR, including activation-induced cytidine deaminase and the LINE-1 repeat-encoded ORF2 endonuclease. These enzymes synergistically generate site-selective DSBs at juxtaposed translocation loci that are ligated by nonhomologous end joining pathway for specific translocations. Our data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes.

      • What Constrains Effective Public Policy Management in Uganda?

        ( Benon C Basheka ),( Rose B Nanara ),( Gerald K Karyeija ) 한국정책학회 2012 International Journal of Policy Studies Vol.3 No.1

        The importance of public policy for national stability, security, and development is generally unquestionable among academics, technocrats, and policy makers. Policy makers and public managers face pressing questions on if a well-formulated policy leads to successful implementation. Formulating sustainable policies for/in developmental states has been a challenge. After continuous debate about the respective roles of the private and public sectors, attention is now shifting towards greater efficiency and effectiveness in public policy administration and implementation (Kiiza, 2007). This paper analyses the political and institutional challenges faced by Uganda in policy management within the agricultural sector; an area that has received limited attention from researchers. The paper argues that developing sustainable policies (policies that live the test of time) remain relevant in organizing and directing public business and those that can expand peoples options and have profound local impact are dependent on the harmonization of political and technical expectations of given policies.

      • KCI등재
      • KCI등재

        Ionized Magnesium Correlates With Total Blood Magnesium in Pediatric Patients Following Kidney Transplant

        Hasson Denise C.,Mohan Shruthi,Rose James E.,Merrill Kyle A.,Goldstein Stuart L.,Benoit Stefanie W.,Varnell Charles D. 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.1

        Background: Abnormal serum magnesium (Mg) concentrations are common and associated with worse mortality in kidney-transplant recipients. Many kidney and transplant-related factors affect Mg homeostasis. The concentration of the active form, ionized Mg (iMg), is not measured clinically, and total Mg (tMg) and iMg correlations have conflicted. We hypothesized that iMg and tMg concentrations show poor categorical agreement (i.e., low, normal, and high) in kidney-transplant recipients but that ionized calcium (iCa) correlates with iMg. Methods: We retrospectively evaluated hypomagnesemia in kidney-transplant recipients over a 2-yr period. We prospectively collected blood at 0–28 days post-transplant to measure correlations between iMg and iCa/tMg. iMg and iCa concentrations in the reference ranges of 0.44–0.65 and 1.0–1.3 mmol/L, respectively, were considered normal. Fisher’s exact test and unweighted kappa statistics revealed category agreements. Pearson’s correlation coefficients and linear regression measured correlations. Results: Among 58 retrospective kidney-transplant recipients, 54 (93%) had tMg<0.66 mmol/L, 28/58 (48%) received Mg supplementation, and 20/28 (71%) had tacrolimus dose adjustments during supplementation. In 13 prospective transplant recipients (N=43 samples), iMg and tMg showed strong category agreement (P=0.0003) and correlation (r=0.71, P<0.001), whereas iMg and iCa did not (P=0.7; r=–0.25, P=0.103, respectively). Conclusions: tMg and iMg exhibited strong correlation following kidney transplantation. However, iCa may not be an accurate surrogate for iMg. Determining the effect of Mg supplementation and the Mg concentration where supplementation is clinically necessary are important next steps.

      • Cepstrum-Domain Model Combination Based on Decomposition of Speech and Noise Using MMSE-LSA for ASR in Noisy Environments

        Hong Kook Kim,Rose, R.C. IEEE 2009 IEEE - ACM Transactions on Audio, Speech, and Lang Vol.17 No.4

        <P>This paper presents an efficient method for combining models of speech and noise for robust speech recognition applications in noisy environments. This method decomposes the cepstrum domain representation of noise-corrupted speech into clean speech cepstrum and background noise cepstrum components using a minimum mean squared error-log spectral amplitude (MMSE-LSA) criterion. Speech recognition is then performed on noisy cepstrum domain observations using a model that is formed by parallel combination of cepstrum domain clean speech distributions and background noise distributions estimated using this MMSE-LSA based noise decomposition. This method is far more efficient than other parallel model combination (PMC) procedures because model combination is performed directly in the cepstrum domain rather than in the linear spectral domain. Whereas background noise model estimation is addressed as a separate issue in existing PMC procedures, this method explicitly incorporates a mechanism to continually update background noise models and signal-to-noise ratio (SNR) estimates over time. The performance of the proposed cepstrum-domain model combination method is compared with a well known implementation of PMC which uses a log-normal approximation when combining speech and background noise model means and variances on a connected digit string recognition task which is subjected to mismatched channel and environment conditions. As a result, it is shown that the proposed model combination technique gives a word error rate that is comparable to PMC when background noise information and SNR are known prior to estimation. The paper will also present the results of experiments where a combination of cepstrum-domain feature compensation and model combination are applied to this task.</P>

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