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Curcumin-loaded Polycaprolactone/Collagen Composite Fibers as Potential Antibacterial Wound Dressing
E. San Martín-Martínez,Casañas-Pimentel,A. Almaguer-Flores,G. Prado-Prone,A. García-García,C. Landa-Solís,A. Hernández-Rangel 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
The development of wound dressings with therapeutical benefits is of great importance in skin tissue engineeringapplications, adding bioactive molecules into biomaterials is a strategy to achieve a better biological response. In this study,four different concentrations of curcumin (CUR; 5, 10, 15 and 20 by weight in relation to the PCL content) were incorporatedinto solutions composed of polycaprolactone (PCL) and collagen (COL) for the manufacture of electrospun fibers. The PCLCOL-CUR fibers were physicochemically characterized in terms of their morphology, wettability, degradation rate,mechanical behavior, and cumulative curcumin release. The in vitro biological properties of the composite membranes werealso evaluated. The results indicated that the membranes have diameters on average of approximately 200 nm. The wateruptake was adequate for exudates remotion in a wound, and the degradation rate of the fibers was highly appropriate toachieve complete skin tissue regeneration. The addition of CUR to composite membranes produced a significant increase inthe mechanical properties which indicate a satisfactory clinical handling. The incorporation of CUR produced a significantdecrease in the planktonic growth of S. aureus over time, however, the antibacterial effect against E. coli was limited, thepresence of CUR did not cause the inhibition of its growth. Finally, the viability of human dermal fibroblasts seeded on thetop of the membranes indicated the cytotoxic dosage effect of CUR, the two highest CUR concentrations produced asignificant loss of cell viability. Overall, our results suggested that the CUR-loaded PCL-COL composite membranes arepromising candidates for use as antibacterial dressings to enhance clinical wound management.
Alfredo Hierro González,Julio César Fernández Travieso,Yoandy Hernández Casas,Susana Borges González,María de los Angeles Camacho Morales,Elena Ferrer Batallie,Anaisa Roja Carralera,Yenney Reyes Nuñez 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.1
Background/Aims: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms. Methods: Monocentric study, open-label, randomized design, with two parallel groups receiving Abexol tablets (150 mg/d) or Abexol suspension (75 mg/d) for 8 weeks. Primary efficacy variable (significant improvement in the total score of Gastrointestinal Symptom Rating Scale [GSRS]). Significant reduction in the intensity of the gastrointestinal-symptoms and the reduction in the consumption of antacids are considered secondary efficacy variable. Short form-36 (SF-36) quality of life questiongenonaire was evaluated as collateral variable. Data were analyzed as per intention to treat. Results: A significantly decrease in the overall score of the survey was observed with respect to the baseline level (p < 0.001) of 81.4% in the Abexol suspension group and 77.9% in the Abexol tablets group. At the end of the trial, most gastrointestinal- symptoms disappeared or reduced significantly. The frequency of consumption of neutralizing antacids was low. The significantly improvement in the perception of the state of health obtained in the Abexol is in correspondence with the improvement achieved in some of the components evaluate in the SF-36 questionnaire. Both treatments were safe and well tolerated. Conclusions: Abexol suspension showed efficacy and safety similar to Abexol tablets in patients with gastrointestinal symptoms, but using half the dose.
Javier Degollado-García,Martin R. Casas-Martínez,Bill Roy Ferrufino Mejia,Juan C. Balcázar-Padrón,Héctor A. Rodríguez-Rubio,Edgar Nathal 대한뇌혈관외과학회 2024 Journal of Cerebrovascular and Endovascular Neuros Vol.26 No.1
Since the first description of the possible utilization of the internal maxillary artery for bypass surgery, there are some reports of its use in aneurysm cases; however, there is no information about the possible advantages of this type of bypass for cerebral ischemic disease.We present a 77-year-old man with a history of diabetes, hypertension, systemic atherosclerosis, and two acute myocardial infarctions with left hemiparesis. Imaging studies reported total occlusion of the right internal carotid artery and 75% occlusion on the left side, with an old opercular infarction and repeated transient ischemic attacks in the right middle cerebral artery territory despite medical treatment. After a consensus, we decided to perform a bypass from the internal maxillary artery to the M2 segment of the middle cerebral artery using a radial artery graft. After performing the proximal anastomosis, the calculated graft’s free flow was 216 ml/min. Subsequently, after completing the bypass, the patency was confirmed with fluorescein videoangiography and intraoperative Doppler. Postoperatively, imaging studies showed improvement in the perfusion values and the hemiparesis from 3/5 to 4+/5. The patient was discharged one week after the operation, with a modified Rankin scale of 1, without added deficits.The use of revascularization techniques in steno-occlusive disease indicates a select group of patients that may benefit from this procedure. In addition, internal maxillary artery bypass has provided a safe option for large areas of ischemia that cannot be supplied with a superficial temporal artery - middle cerebral artery bypass.
The Use of Bituminous Subballast on Future High-Speed Lines in Spain
P. F. Teixeira,P. A. Ferreira,A. Lopez Pita,C. Casas,A. Bachiller 한국철도학회 2009 International Journal of Railway Vol.2 No.1
The development of structural solutions for high-speed or very high-speed tracks that minimize total life cycle costs of the system is a key issue to improve the operational profitability of new investments. In opposition to conventional ballasted tracks, slab track solutions can be a cost-effective solution, but only in the cases where the benefits due to the increase in track availability and the reduction of track maintenance offsets its much higher construction costs. In the cases where such investment is not feasible, it is worth to evaluate possible structural improvements to ballasted track that allow reducing its maintenance needs without increasing too much its construction costs. This paper evaluates the design requirements and the impact of improving conventional high-speed ballasted tracks by using a bituminous subballast layer. It is divided into two main parts: first the design requirements of the structural solutions with bituminous subballast and its possible benefits on high-speed track deterioration, and secondly the evaluation of the economic impact, in terms of construction costs, of using this structural solution material in future Spanish high-speed lines.
Teixeira, P.F.,Ferreira, P.A.,Pita, A. Lopez,Casas, C.,Bachiller, A. The Korean Society for Railway 2009 International Journal of Railway Vol.2 No.1
The development of structural solutions for high-speed or very high-speed tracks that minimize total life cycle costs of the system is a key issue to improve the operational profitability of new investments. In opposition to conventional ballasted tracks, slab track solutions can be a cost-effective solution, but only in the cases where the benefits due to the increase in track availability and the reduction of track maintenance offsets its much higher construction costs. In the cases where such investment is not feasible, it is worth to evaluate possible structural improvements to ballasted track that allow reducing its maintenance needs without increasing too much its construction costs. This paper evaluates the design requirements and the impact of improving conventional high-speed ballasted tracks by using a bituminous subballast layer. It is divided into two main parts: first the design requirements of the structural solutions with bituminous subballast and its possible benefits on high-speed track deterioration, and secondly the evaluation of the economic impact, in terms of construction costs, of using this structural solution material in future Spanish high-speed lines.
Determination of Hund's coupling in 5d oxides using resonant inelastic x-ray scattering
Yuan, Bo,Clancy, J. P.,Cook, A. M.,Thompson, C. M.,Greedan, J.,Cao, G.,Jeon, B. C.,Noh, T. W.,Upton, M. H.,Casa, D.,Gog, T.,Paramekanti, A.,Kim, Young-June American Physical Society 2017 Physical Review B Vol.95 No.23
<P>We report resonant inelastic x-ray scattering (RIXS) measurements on ordered double-perovskite samples containing Re5+ and Ir5+ with 5d(2) and 5d(4) electronic configurations, respectively. In particular, the observedRIXS spectra of Ba2YReO6 and Sr2MIrO6 (M = Y, Gd) show sharp intra-t(2g) transitions, which can be quantitatively understood using a minimal 'atomic' Hamiltonian incorporating spin-orbit coupling. and Hund's coupling J(H). Our analysis yields lambda = 0.38(2) eV with J(H) = 0.26(2) eV for Re5+ and lambda = 0.42(2) eV with J(H) = 0.25(4) eV for Ir5+. Our results provide sharp estimates for Hund's coupling in 5d oxides and suggest that it should be treated on equal footing with spin-orbit interaction in multiorbital 5d transition-metal compounds.</P>