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SUH, BUM CHUN,JEONG, HA-NEUL,YOON, BYUNG SUK,PARK, JI HOON,KIM, HYE JIN,PARK, SUN WHA,HWANG, JUNG HEE,CHOI, BYUNG,CHUNG, KI WHA Spandidos Publications 2013 MOLECULAR MEDICINE REPORTS Vol.8 No.1
<P>Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive multiorgan disease, frequently associated with mutations in the thymidine phosphorylase (TYMP) gene. TYMP encodes thymidine phosphorylase (TP), which has an essential role in the nucleotide salvage pathway for mitochondrial DNA (mtDNA) replication. This study reports an MNGIE patient with novel compound heterozygous missense mutations (Thr151Pro and Leu270Pro) in TYMP. Each mutation was inherited from one parent. Neither mutation was found in the controls and the mutation sites were well conserved between different species. Neither large deletion nor causative point mutations were found in the mtDNA. The patient presented with MNGIE symptoms, including gastrointestinal discomfort, external ophthalmoplegia, pigmentary retinopathy and demyelinating type diffuse sensory motor polyneuropathy. The patient demonstrated an early-onset but mild phenotype, with 9.6%?TP activity; therefore, patients with these compound heterozygous mutations may exhibit a mild phenotype with a variable onset age according to TP activity level.</P>
최서희 ( Suh Hee Choi ),김현주 ( Hyun Ju Kim ),이범천 ( Bum Chun Lee ),문태기 ( Tae Kee Moon ),김남수 ( Nam Soo Kim ) 대한화장품학회 2013 대한화장품학회지 Vol.39 No.2
항균비누에 흔히 사용되는 항균성분인 PCMX와 IPMP에 대하여 ASTM E2752-10 (Standard Guide for Evaluation of Residual Effectiveness of Anti- bacterial Personal Cleansing Products)에 기술된 cup scrub method에 따라 항균 지속력을 평가하였다. 건강한 남녀 총 80명의 피험자를 대상으로 한 실험에서 5% PCMX와 0.1% IPMP를 함유한 액체비누는 대조군에 비해서 E. coli와 S. aureus의 수를 통계학적으로 유의하게 감소시켰으며 27시간 동안 항균효과가 지속되는 것을 확인하였다. 항균성분의 지속력에 대한 인체적용 시험은 국내에서는 처음 시행된 것으로 결과와 함께 보고하는 바이다. This in vivo study via ASTM E2752-10, cup scrub method, was performed to evaluated the residual effectiveness of PCMX and IPMP commonly used in antibacterial soap. The liquid soap having 5% of PCMX and 0.1% of IPMP showed statistically significant reduction of E. coli and S. aurues as compared with control in a trial of 80 healthy volunteers. And its efficacy was maintained for 27 h at least. We report the result of residual effectiveness of antibacterial agents for the first time in Korea.
( Sung Bum Chun ),( Chul Won Lee ),( Kwang Bong Suh ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1
Purpose: Although the internet use is recognized as an essential part of modern life, “excessive internet use” and “internet dependency” among adolescents has become problem rapidly. On the other hand, leisure-time physical activity is proven to have positive effect on happiness in all ages. This study has a purpose to investigate the effect of internet use in leisure-time and leisure-time physical activity on perceived happiness of adolescents in Korea, in order to bring out the negativity of excessive internet use and the positivity of physical activity in leisure time for growing youth. Method: The data from the 11th Korean Youth Risk Behavior Web-based Survey (KYRBWS) conducted in 2015 was used in this study. The survey sampled 70,362 students from 400 middle schools and 400 high schools by stratified cluster sampling of probability sampling. The investigated variables are internet use in leisure-time measured by minutes, physical activity measured by how often participated in exercises a week, and self-rated perceived happiness in 5-point likert scale. All the statistical analyses were conducted using SAS 9.3 for Window program. Frequency analysis, difference analysis and multiple linear regressions were conducted. Result: Firstly, time of internet use was negatively and significantly associated with perceived happiness. Secondly, leisure-time physical activity was positively and significantly related to perceived happiness. Lastly, when internet use and leisure-time physical activity were analyzed together as independent variables, the R-square value was higher than when internet use time alone was analyzed. Conclusion: As proven in preceding researches, internet addiction in adolescents is closely related to their state of mind. This study, although measured in simple use of time for the internet, has also statistically proved that the more time youths are spending time on the internet the less happy they are. The positive relationship between leisure-time physical activity and happiness were confirmed in this study as well. Most importantly, it became better multiple regression model when leisure-time physical activity was controlled in the relationship between internet use and perceived happiness among youths.