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Dollarization or Monetary Independence? Evidence from Venezuela
Alberto José Hurtado Briceño,Sadcidi Zerpa de Hurtado,José U. Mora Mora 한국라틴아메리카학회 2019 라틴아메리카연구 Vol.32 No.4
In the theoretical debate about the benefits of rigid exchange rate regimes, dollarization stands out as a strictly fixed scheme that is used to recover the confidence in the local monetary authority, allow the reduction of inflation, and achieve price stability in countries that adopt it. Venezuela, having monetary authorities with high inflationary bias and being in a phase of instability and volatility of its productive activity, is a good candidate for dollarizing its economy. Given this possibility, this paper identifies whether dollarization is the monetary-exchange regime that currently best suits the Venezuelan economy. We perform an empirical analysis of the costs and benefits of replacing the Bolívar with the U.S. dollar. The empirical evidence tells us that dollarization in Venezuela is undesirable because the benefits in terms of economic growth and low inflation might be limited due to the high costs derived from the low correlation between macroeconomic aggregates of both countries.
Colombia and India: Analysis of the Trade Relationship (2000-2019)
Karol Stefany Rojas Tole,Alberto José Hurtado Briceño 한국라틴아메리카학회 2022 라틴아메리카연구 Vol.35 No.2
Colombia has shown a growing interest in links with Asian countries. Proof of this is the signing, in 2009, of the Bilateral Agreement for the Promotion and Protection of Investments with India —it entered into force on July 3, 2012—; the Free Trade Agreement (FTA) signed with South Korea in 2013, and in force since July 15, 2016; the progress of negotiations to achieve a trade agreement with Japan; and the start of trade missions between companies from Indonesia and Colombia. This paper analyzes the trade relationship between India and Colombia during 20002019. To this purpose, the origin and evolution of the relationship between these two countries is identified. Then, it analyzes their trade link from the analysis of data on imports, exports, and trade balance, and by estimating the revealed comparative advantage, import intensity, relative trade balance and Balassa indices. In addition, the trade opportunities derived from the results obtained are highlighted. Finally, conclusions are presented.
López-Cánovas Juan L.,Hermán-Sánchez Natalia,del Rio-Moreno Mercedes,Fuentes-Fayos Antonio C.,Lara-López Araceli,Sánchez-Frias Marina E.,Amado Víctor,Ciria Rubén,Briceño Javier,de la Mata Manuel,Casta 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the expression and potential role of the spliceosome component PRPF8 (pre-mRNA processing factor 8) in HCC. PRPF8 expression (mRNA/protein) was analyzed in a retrospective cohort of HCC patients (n = 172 HCC and nontumor tissues) and validated in two in silico cohorts (TCGA and CPTAC). PRPF8 expression was silenced in liver cancer cell lines and in xenograft tumors to understand the functional and mechanistic consequences. In silico RNAseq and CLIPseq data were also analyzed. Our results indicate that PRPF8 is overexpressed in HCC and associated with increased tumor aggressiveness (patient survival, etc.), expression of HCC-related splice variants, and modulation of critical genes implicated in cancer-related pathways. PRPF8 silencing ameliorated aggressiveness in vitro and decreased tumor growth in vivo. Analysis of in silico CLIPseq data in HepG2 cells demonstrated that PRPF8 binds preferentially to exons of protein-coding genes, and RNAseq analysis showed that PRPF8 silencing alters splicing events in multiple genes. Integrated and in vitro analyses revealed that PRPF8 silencing modulates fibronectin (FN1) splicing, promoting the exclusion of exon 40.2, which is paramount for binding to integrins. Consistent with this finding, PRPF8 silencing reduced FAK/AKT phosphorylation and blunted stress fiber formation. Indeed, HepG2 and Hep3B cells exhibited a lower invasive capacity in membranes treated with conditioned medium from PRPF8-silenced cells compared to medium from scramble-treated cells. This study demonstrates that PRPF8 is overexpressed and associated with aggressiveness in HCC and plays important roles in hepatocarcinogenesis by altering FN1 splicing, FAK/AKT activation and stress fiber formation.
Brice W Obiang-Obounou,강옥화,최장기,Joon-Ho Keum,김성배,Yong-Sik, Kim,문수현,Mi-Sun Choi,Lamidi Maroufath,권동렬 한국생약학회 2011 Natural Product Sciences Vol.17 No.1
The plant species reported here are used by traditional healers in Gabon for different ailments such as wounds, malaria, fever, gonorrhea or diarrhea. The aim of this study was to evaluate the antimicrobial activities of 7 plants (Strombosiopsis tetrandra, Tetraberlinia bifoliolata, Dichapetalum barbatum, Guibourtia demeusii, Dacryodes normandii, Manniophytum fulvum, Paropsia grewoides) against different strains of both Methicillin-Resistant Staphylococcus aureus (MRSA) and Salmonella. Disc diffusion was first used to determine the antimicrobial effectiveness of the plants' ethanolic extracts. Then the minimum inhibitory concentrations of the crude extracts of either leaves or stem barks of the 7 plants were determined using broth micro-dilution. The ethanolic plant extracts showed very good activity against both MRSA and Salmonella strains where the MICs ranged from 250 mg/ml to 1000 mg/ml. The study shows that many of the tested plants used by Gabonese traditional healers have antimicrobial activities and give support to their traditional use.
Chemical Constituents of Nauclea vanderguchtii
Brice Maxime Nangmou Nkouayeb,Anatole Guy Blaise Azebaze,Georges Bellier Tabekoueng,Willifred Dongmo Tekapi Tsopgni,Bruno Ndjakou Lenta,Marcel Frese,Norbert Sewald,Juliette Catherine Vardamides 한국생약학회 2020 Natural Product Sciences Vol.26 No.2
Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid derivative (2), one alkaloid (16), one peptide derivative (3), and twelve triterpenes (1, 4 - 13). These compounds were identified as rotundanonic acid (1), 2-hydroxy-1,2,3-propanetricarboxylic acid 2-methyl ester (2), asperphenamate (3), lupeol (4), stigmasterol (5), betulin (6), betulenic acid (7), stigmasterol 3-O-b-D-glucopyranoside (8), quinovic acid 3b-O-a-L-rhamnoside (9), a-amyrin (10), 3-oxoquinovic acid (11), ursolic acid (12), hederagenin (13), rotundic acid (14), clethric acid (15), and naucleficine (16) by the analysis of their NMR spectroscopic data including 2D NMR spectra and by comparison of their spectroscopic data reported in the literature. Compounds 1 and 3 were isolated for the first time in the genus Nauclea, and compound 2 was isolated for the first time from the Rubiaceae family. Complete NMR assignations for 1 have been published for the first time.