USN applied to Smart Cold Chain based on the mesh wireless sensor network

Chul Rhee,Shlomo Berkovitch,Yaron Kaufmann,David Wiseman 한국경영과학회 2011 한국경영과학회 학술대회논문집 Vol.2011 No.5

USN, or wireless sensor network, is applied for the real time monitoring for the Supply Chain Industry, starting from the Cold Chain Monitoring (CCM) needs, such as shipments of Fruits & Vegetables, Meat and Medicines. There are a number of different terms related or used in conjunction with the WSN. These are ISM, RFID, GPS, CCM, DASH7 Alliance, ISO18000-7, ZigBee Alliance, IEEE 802.15.4, ZWave WPAN, Wi-Fi, Bluetooth and many, many more. The subject of the WSN is quite a clear, intuitive and simple concept. It goes to the tracing and monitoring of what is needed and possible ?devices, things, living, plants, environment, etc. CartaSense developed the system that enables the customer to take decisions based on: ? Affordable sensors to track and collect ongoing transportation data such as temperature, Humidity and pressure conditions ? Reliable communication with a gateway even in humid and harsh conditions (where regular RF would hardly work) ? Proprietary software to analyze the data and prediction of expected expiration or ripe dates. Major issues and problems in this application which can be accessed by the management science and industrial engineering are analyzed and discussed.

USN applied to Smart Cold Chain based on the mesh wireless sensor network

Chul Rhee,Shlomo Berkovitch,Yaron Kaufmann,David Wiseman 대한산업공학회 2011 대한산업공학회 춘계학술대회논문집 Vol.2011 No.5

USN, or wireless sensor network, is applied for the real time monitoring for the Supply Chain Industry, starting from the Cold Chain Monitoring (CCM) needs, such as shipments of Fruits & Vegetables, Meat and Medicines. There are a number of different terms related or used in conjunction with the WSN. These are ISM, RFID, GPS, CCM, DASH7 Alliance, ISO18000-7, ZigBee Alliance, IEEE 802.15.4, ZWave WPAN, Wi-Fi, Bluetooth and many, many more. The subject of the WSN is quite a clear, intuitive and simple concept. It goes to the tracing and monitoring of what is needed and possible ?devices, things, living, plants, environment, etc. CartaSense developed the system that enables the customer to take decisions based on: ? Affordable sensors to track and collect ongoing transportation data such as temperature, Humidity and pressure conditions ? Reliable communication with a gateway even in humid and harsh conditions (where regular RF would hardly work) ? Proprietary software to analyze the data and prediction of expected expiration or ripe dates. Major issues and problems in this application which can be accessed by the management science and industrial engineering are analyzed and discussed.

Stitched α-Helical Peptides via Bis Ring-Closing Metathesis

Hilinski, Gerard J.,Kim, Young-Woo,Hong, Jooyeon,Kutchukian, Peter S.,Crenshaw, Charisse M.,Berkovitch, Shaunna S.,Chang, Andrew,Ham, Sihyun,Verdine, Gregory L. American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.35

<P>Conformationally stabilized α-helical peptides are capable of inhibiting disease-relevant intracellular or extracellular protein–protein interactions <I>in vivo</I>. We have previously reported that the employment of ring-closing metathesis to introduce a single all-hydrocarbon staple along one face of an α-helical peptide greatly increases α-helical content, binding affinity to a target protein, cell penetration through active transport, and resistance to proteolytic degradation. In an effort to improve upon this technology for stabilizing a peptide in a bioactive α-helical conformation, we report the discovery of an efficient and selective bis ring-closing metathesis reaction leading to peptides bearing multiple contiguous staples connected by a central spiro ring junction. Circular dichroism spectroscopy, NMR, and computational analyses have been used to investigate the conformation of these “stitched” peptides, which are shown to exhibit remarkable thermal stabilities. Likewise, trypsin proteolysis assays confirm the achievement of a structural rigidity unmatched by peptides bearing a single staple. Furthermore, fluorescence-activated cell sorting (FACS) and confocal microscopy assays demonstrate that stitched peptides display superior cell penetrating ability compared to their stapled counterparts, suggesting that this technology may be useful not only in the context of enhancing the drug-like properties of α-helical peptides but also in producing potent agents for the intracellular delivery of proteins and oligonucleotides.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-35/ja505141j/production/images/medium/ja-2014-05141j_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja505141j'>ACS Electronic Supporting Info</A></P>

Lifestyle modifications in an adolescent dormitory: a clinical trial

Ibrahim Abu-Kishk,Michal Alumot-Yehoshua,Gadi Reisler,Shai Efrati,Eran Kozer,Keren Doenyas-Barak,Michal Feldon,Zahi Dagan,Rami Reifen,Matitiahu Berkovitch 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.12

Purpose: Childhood obesity is an increasing public health issue worldwide. We examined dietarypatterns among adolescents in a dormitory school, identified obese adolescents and tried to interveneto improve food habits and physical activity. Methods: We conducted an experimental prospective longitudinal study based on 36 obese (bodymass index [BMI]≥95th percentile) adolescents (aged 12–18 years) compared with controls (healthychildren: normal age-appropriate BMI (BMI≤85th percentile). Six months’ intervention includedlifestyle-modification counseling (once a week by a clinical dietician), and an exercise regimen twicea week, 60 minutes each time, instructed by a professional pediatric trainer). Both groups underwentbaseline measurements at the beginning of the study and 6 months later (arterial stiffness, bloodpressure, pulse, weight and height, hemoglobin, creatinine, liver enzymes, highly sensitive C-reactiveprotein and complete lipid profile). Results: Twenty-one participants completed the study. Low compliance from participants, schoolstaff and parents was observed (participation in planned meetings; 71%–83%). BMI significantlydecreased from 32.46±3.93 kg/m2 to 30.32±3.4 kg/m2 (P=0.002) in the study group. Arterialstiffness was not significantly different between the 2 groups and did not change significantly after 6months’ intervention (P=0.494). No significant changes in CRP and lipid profile were observed afterthe intervention. Conclusion: Making lifestyle modifications among adolescents in a dormitory school is a complex task. Active intervention indeed ameliorates BMI parameters. However, in order to maximize the beneficialeffects, a multidisciplinary well-trained team is needed, with emphasis on integrating parents and theschool environment.

Lifestyle modifications in an adolescent dormi­tory: a clinical trial

Abu-Kishk, Ibrahim,Alumot-Yehoshua, Michal,Reisler, Gadi,Efrati, Shai,Kozer, Eran,Doenyas-Barak, Keren,Feldon, Michal,Dagan, Zahi,Reifen, Rami,Berkovitch, Matitiahu The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.12

Purpose: Childhood obesity is an increasing public health issue worldwide. We examined dietary patterns among adolescents in a dormitory school, identified obese adolescents and tried to intervene to improve food habits and physical activity. Methods: We conducted an experimental prospective longitudinal study based on 36 obese (body mass index $[BMI]{\geq}95th$ percentile) adolescents (aged 12-18 years) compared with controls (healthy children: normal age-appropriate BMI ($BMI{\leq}85th$ percentile). Six months' intervention included lifestyle-modification counseling (once a week by a clinical dietician), and an exercise regimen twice a week, 60 minutes each time, instructed by a professional pediatric trainer). Both groups underwent baseline measurements at the beginning of the study and 6 months later (arterial stiffness, blood pressure, pulse, weight and height, hemoglobin, creatinine, liver enzymes, highly sensitive C-reactive protein and complete lipid profile). Results: Twenty-one participants completed the study. Low compliance from participants, school staff and parents was observed (participation in planned meetings; 71%-83%). BMI significantly decreased from $32.46{\pm}3.93kg/m^2$ to $30.32{\pm}3.4kg/m^2$ (P=0.002) in the study group. Arterial stiffness was not significantly different between the 2 groups and did not change significantly after 6 months' intervention (P=0.494). No significant changes in CRP and lipid profile were observed after the intervention. Conclusion: Making lifestyle modifications among adolescents in a dormitory school is a complex task. Active intervention indeed ameliorates BMI parameters. However, in order to maximize the beneficial effects, a multidisciplinary well-trained team is needed, with emphasis on integrating parents and the school environment.