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Katya Cristina Rocha,Maria Luiza dos Santos Vieira,Registila Libania Beltrame,Jairo Cartum,Sarah Isabel P. M. do N. Alves,Ligia Ajaime Azzalis,Virginia Berlanga Campos Junqueira,Edimar Cristiano Perei 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.6
Essential to human health, selenium (Se) has enzymatic functions of fundamental importance to human biology due to its effects on DNA damage repair, its antioxidant properties, and cancer prevention. The best studied relationships between Se and the immune system is its role in the functions of neutrophils and of lymphocytes. Despite these observations, it is not yet clear by which mechanism Se is able to modify the immune status. This was a double-blind, crossover study: Group 1 received Se and Group 2 received placebo (30 days). After this, Group 1 received placebo and Group 2 received Se (30 days). Every 30 days, blood samples were collected for white blood cell count, red blood cell count, and Ig level measurement (IgA, IgG, IgE, IgM). Of the 36 patients, 17 were suffering from leukemia/lymphomas (LL) and 19 from solid tumors (ST). In the ST group’s leukogram, a significant increase in neutrophils was observed after Se usage (P = .0192). During the analyzed period, Se minimized the triggering of neutropenia cases in both groups. IgA and IgG levels in ST patients were significantly higher than those identified in LL patients after Se usage (P = .0051 and P = .0055). For IgA, a significant increase in its production, after Se usage, was observed in the ST group when compared to the LL (P = .0011). The same did not occur to the IgM and IgE immunoglobulins. In our study, the supplementation with Se reduced the neutropenic cases (LL and ST patients) and reduced IgG and IgA levels in LL and increased in ST group.
Causes of Failure of Anterior Cruciate Ligament Reconstruction and Revision Surgical Strategies
( Paolo Di Benedetto ),( Enrico Di Benedetto ),( Andrea Fiocchi ),( Alessandro Beltrame ),( Araldo Causero ) 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.4
Purpose: Long-term outcomes of anterior cruciate ligament (ACL) reconstruction are good or excellent; however, 0.7%-20% of patients suffer from recurrent instability due to graft failure. The purpose of this paper was to analyse failure aetiology and the possibilities of revision surgical strategies, with a description of our experience. We obtained optimal and good results in most of our patients. Materials and Methods: We retrospectively reviewed 42 patients who underwent revision surgery (43 revisions) due to relapsing instability after ACL reconstruction between 2006 and 2015. We used allografts in 39 cases and autografts in 4 cases. Results: The 85.7% of the patients obtained optimal results (normal knee; group A) and the 7.2% obtained good results (nearly normal knee; group B) according to the International Knee Documentation Committee score. The most frequent failure causes were traumatic events, non-anatomic tunnel placement, and lack of graft incorporation. Conclusions: A correct revision surgery requires accurate patient evaluation and knee imaging. Preoperative planning starts with the identification of the cause of failure of the primary reconstruction. Then, the most suitable procedure should be determined for each case. It is also important to accurately inform the patient of all the complexity of an ACL revision surgery even if it is a procedure with high rates of excellent and good outcomes.
Maria Luiza dos Santos Vieira,Fernando Luiz Affonso Fonseca,Larissa Grossi Costa,Registila Libania Beltrame,Carolina Machado de Sousa Chaves,Jairo Cartum,Sarah Isabel P. M. do N. Alves,Ligia Ajaime Az 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
The drugs used in chemotherapy treatments have little specificity, attack tumor cells, and also injure proliferative tissues. Knowledge of the functions of micronutrients has greatly increased, especially of Selenium (Se) that presents immunomodulatory and antitumor functions. The present study evaluated the health-related quality of life of patients undergoing chemotherapy for the treatment of leukemias and lymphomas (LL) and solid tumors (ST) while receiving Selenium (Se) supplementation. This is a randomized, double-blind, crossover study that evaluated the quality of life (EORTC-QLQC30 questionnaire), renal and liver functions of patients supplemented with Se. There was no statistically significant alteration in LL patients. However, the fatigue and nausea scores after 30 days did decrease in this group as well as in the ST group. After 1 year supplementation with Selenium, a more noticeable decrease in the scores concerning fatigue and nausea could be observed in the ST group, when compared with the beginning of the study. The LL patients also presented a decrease in the fatigue scores and physical functions. The kidney function as well as liver function has improved after Selenium supplementation when compared with the placebo intake in LL and ST patients, more remarkably in the LL group. Supplementation with Selenium promotes the reduction of chemotherapy side effects in cancer patients, especially by improving the conditions of patients with fatigue, nausea, and impaired physical function. Renal and liver functions have also improved.
Akerib, D.S.,Akerlof, C.W.,Akimov, D.Yu.,Alsum, S.K.,Araú,jo, H.M.,Arnquist, I.J.,Arthurs, M.,Bai, X.,Bailey, A.J.,Balajthy, J.,Balashov, S.,Barry, M.J.,Belle, J.,Beltrame, P.,Benson, T.,Bernard North-Holland 2017 Astroparticle physics Vol.96 No.-
<P>The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double -vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of U-238(e) < 1.6 mBq/kg, U-238(I) < 0.09 mBq/kg, Th-232(e) = 0.28 +/- 0.03 mBq/kg, Th-232(I) = 0.25 +/- 0.02 mBq/kg, K-40 <0.54 mBq/kg, and (60) Co <0.02 mBq/kg (68% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of 0.160 +/- 0.001(stat) +/- 0.030(sys) counts. (C) 2017 Elsevier B.V. All rights reserved.</P>