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RISS 인기검색어
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- 저자 : Basunia, Mafroz Ahmed (검색결과 4 건)
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Hossain, Shahdat,Rahaman, Asiqur,Nahar, Taslima,Basunia, Mafroz Ahmed,Mowsumi, Ferdousi Rahman,Uddin, Borhan,Shahriar, Masum,Mahmud, Ishtiaq 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1
We investigated the effect of Syzygium cumini (L.) Skeels seed extract on the oxidative stress of brain cortical tissues of alcohol-treated rats. The in vitro antioxidative effect of methnolic S. cumini seed extract was initially compared with those of the buytylated hydroxyl toluene (BHT) and Vitamin C, by determining their DPPH-free radical scavenging activity. The S. cumini seed extract exhibited stronger free radical scavenging activity than those of the BHT and Vitamin C. Cortex homogenates were then directly incubated with 15% ethanol and/or Fenton's reagent ($H_2O_2+Fe_2SO_4$) to induce in vitro oxidative stress in the absence or presence of S. cumini seed extract. The S. cumini seed extract significantly reduced the levels of lipid peroxide (LPO) in the cortical homogenates. Twenty four rats were then divided into four groups: Control, S. cumini seed extract (SE)-administered, 15% ethanol-fed (EtOH) and EtOH+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 8 weeks significantly (P<0.05) decreased the levels of LPO in the cortex of the EtOH+SE rats, suggesting that S. cumini seed not only scavenged the DPPH-free radicals and obstructed the ethanol/Fenton's reagents-induced in vitro oxidative stress of the cortical tissues but also reduced their in vivo formation. These results suggest that S. cumini seed could be used as a potential antioxidant therapy for alcoholics.
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Sujan Bhowmick,Marzan Sarkar,Jakir Hussain,Mehedi Hassan,Mafroz Basunia,Taslima Nahar,Azizur Rahman,Borhan Uddin,Shahdat Hossain 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.4
Parkinson’s disease (PD) results mostly from the degeneration of dopaminergic neurons in the substantia nigra pars compacta. It is characterized by the manifestations of anxiety, tremor, muscle rigidity, bradykinesia and cognitive impairments. Oxidative stress is attributed to the neurodegeneration of PD. Curcuma longa is a commonly used spice and has high levels of anti-oxidative phyto-constituents. Here, we evaluated whether the chronic oral administration of C. longa extract affects the degree of anxiety, neuromotor and cognitive deficits of 6-hydroxydopamine (6-OHDA)-infused PD model rats. Following the surgery, animals were orally administered with C. longa extract for twelve weeks. The degree of anxiety/depression, motor and cognitive performances were determined with a variety of neurobehavioral experimental paradigms, including elevated plus, Morris water maze task, rotarod, open field, forced swim, sucrose preference and tail suspension tests. Brain levels of lipid peroxide (LPO) were measured by standard method. Tumor necrosis factor-α (TNFα), α-synuclein, synaptosomeassociated protein-25 (SNAP25) and brain-derived neurotrophic factor (BDNF) of the brain tissues were measured by ELISA. Oral administration of C. longa significantly (P < 0.05) protected the deterioration of the motor activity, learning-related memory cognitions and the degree of anxiety- and depression-like behaviors in PD model rats. The preventive effects were accompanied with decreased brain levels of LPO, TNFα, α-synuclein and increased levels of cognition-related proteins SNAP-25 and BDNF. The experimental results suggest that C. longa ameliorates PD-like symptoms by suppressing the oxidative/pro-inflammatory stress and levels of α-synuclein and increasing the levels of SNAP-25 and BDNF.
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Capture Gamma-ray Libraries for Nuclear Applications
B. W. Sleaford,N. Summers,J. Escher,R. B. Firestone,S. Basunia,A. Hurst,M. Krticka,G. Molnar,T. Belgya,Zs Revay,H. D. CHOI 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The neutron capture reaction is useful in identifying and analyzing the gamma-ray spectrum from an unknown assembly as it gives unambiguous information on its composition. This can be done passively or actively where an external neutron source is used to probe an unknown assembly. There are known capture gamma-ray data gaps in the ENDF libraries used by transport codes for various nuclear applications. The Evaluated Gamma-ray Activation file (EGAF) is a new thermal neutron capture database of discrete line spectra and cross sections for over 260 isotopes that was developed as part of an IAEA Coordinated Research Project. EGAF has been used to improve the capture gamma production in ENDF libraries. For medium to heavy nuclei the quasi continuum contribution to the gamma cascades is not experimentally resolved. The continuum contains up to 90% of all the decay energy and is modeled here with the statistical nuclear structure code DICEBOX. This code also provides a consistency check of the level scheme nuclear structure evaluation. The calculated continuum is of sufficient accuracy to include in the ENDF libraries. This analysis also determines new total thermal capture cross sections and provides an improved RIPL database. For higher energy neutron capture there is less experimental data available making benchmarking of the modeling codes more difficult. We use CASINO, a version of DICEBOX that is modied for this purpose. This can be used to simulate the neutron capture at incident neutron energies up to 20 MeV to improve the gamma-ray spectrum in neutron data libraries used for transport modeling of unknown assemblies.
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