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RISS 인기검색어
- 검색키워드
- 저자 : Mafroz Basunia (검색결과 2 건)
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Hossain, Shahdat,Rahaman, Asiqur,Nahar, Taslima,Basunia, Mafroz Ahmed,Mowsumi, Ferdousi Rahman,Uddin, Borhan,Shahriar, Masum,Mahmud, Ishtiaq 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1
We investigated the effect of Syzygium cumini (L.) Skeels seed extract on the oxidative stress of brain cortical tissues of alcohol-treated rats. The in vitro antioxidative effect of methnolic S. cumini seed extract was initially compared with those of the buytylated hydroxyl toluene (BHT) and Vitamin C, by determining their DPPH-free radical scavenging activity. The S. cumini seed extract exhibited stronger free radical scavenging activity than those of the BHT and Vitamin C. Cortex homogenates were then directly incubated with 15% ethanol and/or Fenton's reagent ($H_2O_2+Fe_2SO_4$) to induce in vitro oxidative stress in the absence or presence of S. cumini seed extract. The S. cumini seed extract significantly reduced the levels of lipid peroxide (LPO) in the cortical homogenates. Twenty four rats were then divided into four groups: Control, S. cumini seed extract (SE)-administered, 15% ethanol-fed (EtOH) and EtOH+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 8 weeks significantly (P<0.05) decreased the levels of LPO in the cortex of the EtOH+SE rats, suggesting that S. cumini seed not only scavenged the DPPH-free radicals and obstructed the ethanol/Fenton's reagents-induced in vitro oxidative stress of the cortical tissues but also reduced their in vivo formation. These results suggest that S. cumini seed could be used as a potential antioxidant therapy for alcoholics.
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Sujan Bhowmick,Marzan Sarkar,Jakir Hussain,Mehedi Hassan,Mafroz Basunia,Taslima Nahar,Azizur Rahman,Borhan Uddin,Shahdat Hossain 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.4
Parkinson’s disease (PD) results mostly from the degeneration of dopaminergic neurons in the substantia nigra pars compacta. It is characterized by the manifestations of anxiety, tremor, muscle rigidity, bradykinesia and cognitive impairments. Oxidative stress is attributed to the neurodegeneration of PD. Curcuma longa is a commonly used spice and has high levels of anti-oxidative phyto-constituents. Here, we evaluated whether the chronic oral administration of C. longa extract affects the degree of anxiety, neuromotor and cognitive deficits of 6-hydroxydopamine (6-OHDA)-infused PD model rats. Following the surgery, animals were orally administered with C. longa extract for twelve weeks. The degree of anxiety/depression, motor and cognitive performances were determined with a variety of neurobehavioral experimental paradigms, including elevated plus, Morris water maze task, rotarod, open field, forced swim, sucrose preference and tail suspension tests. Brain levels of lipid peroxide (LPO) were measured by standard method. Tumor necrosis factor-α (TNFα), α-synuclein, synaptosomeassociated protein-25 (SNAP25) and brain-derived neurotrophic factor (BDNF) of the brain tissues were measured by ELISA. Oral administration of C. longa significantly (P < 0.05) protected the deterioration of the motor activity, learning-related memory cognitions and the degree of anxiety- and depression-like behaviors in PD model rats. The preventive effects were accompanied with decreased brain levels of LPO, TNFα, α-synuclein and increased levels of cognition-related proteins SNAP-25 and BDNF. The experimental results suggest that C. longa ameliorates PD-like symptoms by suppressing the oxidative/pro-inflammatory stress and levels of α-synuclein and increasing the levels of SNAP-25 and BDNF.
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