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공성화,방찌야,서민숙,현신숙,김희정,이미애1,이미애2,유현희,허재경,김은애,박경숙 성인간호학회 2004 성인간호학회지 Vol.16 No.1
Purpose: The purpose of this study is to evaluate the knowledge and attitudes of oncology ward nurses toward cancer pain management and to find ways to improve the educational program for nurses. Method: A total of 209 nurses working at the oncology ward of three hospitals in Seoul and a Gyenggi Province. The survey instrument used was the 32-item scale for evaluating nurses knowledge and attitudes originally developed by McCaffery and Ferrell'(1990). that was by Kim'(1997). Result: In terms of the nurses knowledge of pain management. the result showed that the nurses scored an average of 67.8 out of 100 for phamacokinetics of opioids. 84.8 for classification of analgesics, 60.1 for pain assessment, and 70.7 for drug administration. 18.2% of the nurses hesitate to inject the narcotic agent because of concerns regarding the drug's potential side effects. there was significant difference in the knowledge of pain management according to the general characteristics of pain in terms of the nurses age(p=.001), position (p=.016). years of experiences(p=.002), experience of cancer pain education(p= .001). Conclusion: The also showed that nurses working at cancer ward lack knowledge. It is important to provide intensive education to nurses about cancer pain management.
사람 신장의 근위세뇨관상피세포에서 Monocyte Chemoattractant Protein-1의 발현에 대한 Endothelin-1의 효과
김형욱 ( Kim Hyeong Ug ),이명자 ( Lee Myeong Ja ),김소양 ( Kim So Yang ),신영신 ( Sin Yeong Sin ),양철우 ( Yang Cheol U ),진동찬 ( Jin Dong Chan ),김용수 ( Kim Yong Su ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
배 경 : Endothelin-1은 신장 혈관과 사구체간질세포를 수축시키는 혈역학적 작용 뿐 아니라 사구체간질세포 증식의 촉진, 세포외 기질의 축적 등과 같은 면역학적 기전으로도 신 손상에 관여한다. 그러나 endothelin-1이 화학주성물질의 분비 조절 또는 면역세포의 침윤에 관여하는 지는 밝혀지지 않았다. 본 연구에서는 endothelin-1이 근위세뇨관상피세포에서 염증세포의 침윤에 중요한 역할을 하는 화학주성물질 중 하나인 monocyte chemoattractant protein-1 (MCP-1)의 발현에 미치는 영향을 조사하였다. 방 법 : 사람의 신장 근위세뇨관상피세포를 배양하여 endothelin-1 (10^(8)-10^(6) M)을 처리하고 8, 16, 24, 48 및 72시간 후에 배양액 내 MCP-1 농도를 ELISA 방법으로 측정하였다. Endothelin-1 자극후 MCP-1 mRNAdm 발현정도는 Northern blot 방법으로 평가하였으며 MCP-1 유전자 발현에 관여하는 전사인자로서 NF-κB와 AP-1의 활성도는 electrophoretic mobility shift assay (EMSA) 방법으로 측정하였다. 결 과 : 근위세뇨관상피세포 배양액 내 MCP-1 농도는 자극 전에 비해 endothelin-1 (10^(-7) M)으로 자극 후 48시간에 유의하게 증가되었으며 여러 농도의 endothelin-1 (10^(-8)-10^(-6) M)으로 자극하였을 경우 MCP-1 단백질 생성은 농도 의존적으로 증가하였다. MCP-1 mRNA 발현도 endothelin-1에 의해 증가되었다. Endothelin-1 NF-κB와 AP-1 활성도를 증가시켰으며 NF-κB 복합체는 p65와 p50이, AP-1 복합체에는 c-Fos와 c-Jun이 증가된 활성도의 주요 아형임을 알 수 있었다. 결 론 : Endothelin-1은 신장 근위세뇨관상피세포에서 MCP-1 단백질과 유전자 발현을 증가시켰으며 NF-κB와 AP-1 활성도를 증가시켰다. 이러한 결과는 endothelin-1이 근위세뇨관상피세포에서 MCP-1 발현의 증가를 통한 염증성 변화 유발로 신 손상에 관여할 것임을 시사하며, MCP-1 발현의 증가의 기전으로 endothelin-1에 의한 NF-κB 및 AP-1 활성도 증가의 가능성을 시사한다. Background : Monocyte chemoattractant protein 1 (MCP-1) is produced by renal cells and an important mediator for monocyte/macrophage infiltration in various inflammatory renal diseases. In the process of renal disease, endothelin-1 is known to play an active role in cell growth, inflammation and fibrosis. The aim of this study was to investigate whether endothelin-1 regulates MCP-1 expression in cultured human proximal tubular epithelial cells. Methods : Primary cultured human proximal tubular epithelial cells (PTEC) were incubated with or without various dose of endothelin-1. MCP-1 concentration in PTEC conditioned medium was measured by sandwich ELISA. MCP-1 mRNA expression was analyzed by Northern blotting. The NF-κB or AP-1 activity in response to endothelin-1 was measured by electrophoretic mobility shift assay. Results : Endothelin-1 (10?? M) stimulated MCP-1 production in PTEC, which was significant at 48 hours and various doses of endothelin-1 (10?? 10? M) increased MCP-1 production from PTEC in a dose-dependent manner. Northern blot analysis revealed that endothelin-1 stimulated MCP-1 mRNA expression. Endothelin-1 (10?? M) stimulated both AP-1 binding activity and NF-κB subunit bound to the DNA probe and that c-Fos and C-Jun are major AP-1 subunit bound to the DNA probe. Conclusion : Our results suggest that endothelin-1 may stimulate MCP-1 expression in proximal tubular epithelial cells through the activation of NF-κB and AP-1 binding activity. (Korean J Nephrol 2003;22(6):655-663)
포스터 전시 : 상부위장관 ; 드문 임상양상을 보인 십이지장 중복낭(Duodenal Duplication Cyst) 3예
김현수 ( Kim Hyeon Su ),주광로 ( Ju Gwang Lo ),신수진 ( Sin Su Jin ),우순주 ( U Sun Ju ),박종호 ( Park Jong Ho ),신정우 ( Sin Jeong U ),방성조 ( Bang Seong Jo ),김도하 ( Kim Do Ha ),박능화 ( Park Neung Hwa ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
위장관 중복낭은 주로 소아에서 발견되는 드문 선천성 기형으로 위장관 어디에서나 발생될 수 있으나 회장 말단이 가장 흔히 발생되는 장소이며 십이지장에서 발생하는 경우는 4~12%로 주로 구부와 2부에 국한되어 발생한다. 임상양상은 장 폐색이 주된 소견이며 이외 폐쇄성 황달, 췌장염, 출혈, 및 천공 등이 드물게 나타날 수 있다. 본 증례는 성인에서 발견되고 병리학적으로 확진된 십이지장 중복낭 3예로 각각 폐쇄성 황달 및 췌장염, 재발성 췌장염, 출혈과 천
김방신(Bang-Sin Kim),허다니엘(Daniel Hur),김경락(Kyung-Rak Kim),양지웅(Ji-Woong Yang),정연욱(Younwook Jeoung),국민석(Min-Suk Kook),오희균(Hee-Kyun Oh),유선열(Sun-Youl Ryu),박홍주(Hong-Ju Park) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.6
Introduction: This study examined the effect of a conservative neck dissection in patients with head and neck cancer. Materials and Methods: A total of 24 patients, who underwent a conservative neck dissection for the treatment of oral cancer from January 2002 to December 2007, were included. All procedures were performed by one oral and maxillofacial surgeon. The mean age was 58.2 years (range, 19 to 79 years). The medical recordings, pathologic findings, and radiographic findings were evaluated. The mean follow up period was 41.1 months (range, 4 to 88 months). Results: 1. Oral cancer was more common in men than women with a 3:1 ratio. 2. Histopathologically, squamous cell carcinoma(83%) was the most prevalent oral cancer in this study. 3. The most common primary site was the tongue(6 cases, 25%) followed by the mouth floor (5 cases, 21%), buccal mucosa (3 cases, 13%), lower lip, mandible, palate (2 cases, respectively) and salivary gland, retromolar area, oropharynx, alveolus (1 case, each). 4. Three out of the 24 (13%) subjects had a recurrence at the primary sites. 5. Two out of 24 (8%) subjects had a distant metastasis. 6. All 24 patients survived and there were eleven patients who passed 5 years postoperatively. Conclusion: A conservative neck dissection is a reliable and effective method for controlling neck node metastases in patients with oral cancer of the N0 or N1 neck node without serious complications.
신성철 ( Sin Seong Cheol ),김윤구 ( Kim Yun Gu ),백현정 ( Baeg Hyeon Jeong ),임영환 ( Im Yeong Hwan ),여호명 ( Yeo Ho Myeong ),김응호 ( Kim Eung Ho ),김정아 ( Kim Jeong A ),이방훈 ( Lee Bang Hun ),강우헌 ( Kang U Heon ),김범 ( Ki 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.3
A 21-year-old male was presented with sudden headache, fever, petechiae and neck stiffeness. The diagnosis of meningococcal meningitis was confirmed by examination of cerebrospinal fluid. The clinical symptoms of the illness were improved after treatment of antibiotics. However the paient developed generalized edema, oliguria, azoternia, and heavy proteinuria in the recovery phas of illness. Low serum C3 level was also noted. A kidney biopsy was perfromed and showed the features of postinfectious glomerulonephritis and typical subepithelial humps on electron-microscopic examination. His sysmptoms and laboratory findings were improved, and C3 level re turned to normal range after conservative treatment. We suggest that a complement deficiency should be reled out in patients of glomerulonephritis developed during the recovery phase of meningococcal men ingitis. C3 nephritic factor detection and renal biopsy should be carefully considered in these patients. (Korean J Nephrol 2003;23(3):321-325
신미정 ( Sin Mi Jeong ),김형욱 ( Kim Hyeong Ug ),양철우 ( Yang Cheol U ),김용수 ( Kim Yong Su ),김석영 ( Kim Seog Yeong ),최의진 ( Choe Ui Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.4
목 적 : Monocyte chemoattractant protein-1 (MCP-1)은 단핵구, T 임파구 및 호염구를 선택적으로 유도하며 다양한 신장질환에서 발현된다. Endothelin-1은 염증성 사구체신염을 비롯한 신장질환의 신장조직 내 발현이 증가되나 그 작용기전은 자세히 알려지지 않았다. 본 연구에서는 횐쥐의 사구체간질세포를 배양하여 endothelin-1 (ET-1), endothelin-2 (ET-2) 및 endothelin-3 (ET-3)의 MCP-1 발현에 대한 효과를 조사하였다. 방 법 : 흰쥐의 사구체간질세포를 배양하여 ET-1, ET-2, 및 ET-3로 자극한 후 사구체간질세포 배양액 내 단핵구 화학주성 활성도는 modified Boyden chamber를 이용한 화학주성검사법으로 측정하고 ET-1, ET-2, 및 ET-3 자극 시간 및 농도에 따른 MCP-1 mRNA의 발현은 Northern blot 검사법을 이용하여 측정하였다. 결 과 : ET-1, ET-2, 및 ET-3로 자극한 후 사구체간질세포에서 분비하는 단핵구 화학주성활성도는 자극 전에 비해 농도에 비례하여 증가하였으며 10^(-9)과 10^(-8) M의 농도에서 유의하게 증가하였다. ET-1, ET-2, 및 ET-3는 높은 농도에서 MCP-1 mRNA 발현을 증가시켰으며 이러한 증가는 4시간부터 시작되어 24시간에 가장 증가되었다. 결 론 : ET-1, ET-2 및 ET-3는 사구체간질세포에서 분비하는 단핵구 화학 주성 활성도와 MCP-1 mRNA 발현을 증가시키며 이를 통해 염증성 신장질환에서 단핵구의 신장 조직 내 침윤에 따른 신 손상에 중요한 역할을 담당할 것으로 생각된다. Background : Monocyte chemoattractant protein-1 (MCP-1) is an important mediator for monocyte/macrophage infiltration in various inflammatory renal diseases and is produced by renal cells. In the process of renal diseases, endothelin-1 (ET-1) is known to play an active role in cell growth, inflammation and fibrosis. The aim of this study was to investigate whether three isoforms of endothelin regulate MCP-1 expression in cultured mesangial cells. Methods : Mesangial cells were incubated with or without various doses of ET-1, ET-2, or ET-3. To determine the monocyte chemotactic activity, chemotaxis assay was performed in modified Boyden chambers using freshly isolated human monocytes. MCP-1 mRAN expression in mesangial cells was measured by Northern blot analysis. Results : ET-1, ET-2, or ET-3 stimulated monocyte chemotactic activity released from mesangial cells in a dose-dependent manner. ET-1, ET-2 and ET-3 also stimulated MCP-1 mRNA expression in a time-dependent manner, which was seen as early as 4 hours and was maintained up to 24 hours. Conclusion : These data suggest that ET-1, ET-2 and ET-3 stimulate MCP-1 expression in mesangial cells and may contribute to the monocyte/macrophage infiltration in inflammatory renal diseases. (Korean J Nephrol 2003;22(4):358-365)
일반연제 발표 : 신이식 전 Panel Reactive Antibody (PRA) 검사와 PRA-identification 검사의 임상적 유용성
김성용 ( Kim Seong Yong ),김영수 ( Kim Yeong Su ),유혜영 ( Yu Hye Yeong ),김재억 ( Kim Jae Eog ),신석준 ( Sin Seog Jun ),최범순 ( Choe Beom Sun ),양철우 ( Yang Cheol U ),김용수 ( Kim Yong Su ),장윤식 ( Jang Yun Sig ),방병기 ( Bang 대한신장학회 2003 춘계학술대회 초록집 Vol.22 No.1