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Zhao, Jian,Giles, Brendan M,Taylor, Rhonda L,Yette, Gabriel A,Lough, Kara M,Ng, Han Leng,Abraham, Lawrence J,Wu, Hui,Kelly, Jennifer A,Glenn, Stuart B,Adler, Adam J,Williams, Adrienne H,Comeau, Mary E H. K. Lewis 2016 Annals of the rheumatic diseases Vol.75 No.1
<P><B>Objectives</B></P><P>Systemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (<I>CR2/CD21</I>) that were associated with decreased risk of SLE. This study aimed to identify the causal variant for this association.</P><P><B>Methods</B></P><P>Genotyped and imputed genetic variants spanning <I>CR2</I> were assessed for association with SLE in 15 750 case-control subjects from four ancestral groups. Allele-specific functional effects of associated variants were determined using quantitative real-time PCR, quantitative flow cytometry, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP)-PCR.</P><P><B>Results</B></P><P>The strongest association signal was detected at rs1876453 in intron 1 of <I>CR2</I> (p<SUB>meta</SUB>=4.2×10<SUP>−4</SUP>, OR 0.85), specifically when subjects were stratified based on the presence of dsDNA autoantibodies (case-control p<SUB>meta</SUB>=7.6×10<SUP>−7</SUP>, OR 0.71; case-only p<SUB>meta</SUB>=1.9×10<SUP>−4</SUP>, OR 0.75). Although allele-specific effects on B cell <I>CR2</I> mRNA or protein levels were not identified, levels of complement receptor 1 (<I>CR1/CD35)</I> mRNA and protein were significantly higher on B cells of subjects harbouring the minor allele (p=0.0248 and p=0.0006, respectively). The minor allele altered the formation of several DNA protein complexes by EMSA, including one containing CCCTC-binding factor (CTCF), an effect that was confirmed by ChIP-PCR.</P><P><B>Conclusions</B></P><P>These data suggest that rs1876453 in <I>CR2</I> has long-range effects on gene regulation that decrease susceptibility to lupus. Since the minor allele at rs1876453 is preferentially associated with reduced risk of the highly specific dsDNA autoantibodies that are present in preclinical, active and severe lupus, understanding its mechanisms will have important therapeutic implications.</P>
Aad, G.,Abbott, B.,Abbott, D.C.,Abed Abud, A.,Abeling, K.,Abhayasinghe, D.K.,Abidi, S.H.,AbouZeid, O.S.,Abraham, N.L.,Abramowicz, H.,Abreu, H.,Abulaiti, Y.,Acharya, B.S.,Achkar, B.,Adachi, S.,Adam, L. North-Holland Pub. Co 2020 Physics letters. Section B Vol.801 No.-
<P><B>Abstract</B></P> <P>A search for non-resonant Higgs boson pair production, as predicted by the Standard Model, is presented, where one of the Higgs bosons decays via the H → b b channel and the other via one of the H → W <SUP> W ⁎ </SUP> / Z <SUP> Z ⁎ </SUP> / τ τ channels. The analysis selection requires events to have at least two <I>b</I>-tagged jets and exactly two leptons (electrons or muons) with opposite electric charge in the final state. Candidate events consistent with Higgs boson pair production are selected using a multi-class neural network discriminant. The analysis uses 139 fb<SUP>−1</SUP> of <I>pp</I> collision data recorded at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. An observed (expected) upper limit of 1.2 ( 0.9 − 0.3 + 0.4 ) pb is set on the non-resonant Higgs boson pair production cross-section at 95% confidence level, which is equivalent to 40 ( 29 − 9 + 14 ) times the value predicted in the Standard Model.</P>
Characterization of Some Continuous Distributionsby Properties of Partial Moments
B. Abraham,N. Unnikrishnan Nair,P. G. Sankaran 한국통계학회 2007 Journal of the Korean Statistical Society Vol.36 No.3
In this paper we present characterizations of the Pareto, Lomax, expo-nential and beta models by some properties of theirrth partial momentdened as r(t) = E[(X t)+ ]r, where (X t)+ = max(X t;0). Giventhe partial moments at a few truncation points, these results enable us tocalculate the moments at many other points.
CHARACTERIZATION OF SOME CONTINUOUS DISTRIBUTIONS BY PROPERTIES OF PARTIAL MOMENTS
Abraham, B.,Nair, N. Unnikrishnan,Sankaran, P.G. The Korean Statistical Society 2007 Journal of the Korean Statistical Society Vol.36 No.3
In this paper we present characterizations of the Pareto, Lomax, exponential and beta models by some properties of their $r^{th}$ partial moment defined as ${\alpha}_r(t)=E[(X-t)^+]^r$, where $(X-t)^+ = max(X-t,0)$. Given the partial moments at a few truncation points, these results enable us to calculate the moments at many other points.
Aad, G.,Abbott, B.,Abbott, D.C.,Abed Abud, A.,Abeling, K.,Abhayasinghe, D.K.,Abidi, S.H.,AbouZeid, O.S.,Abraham, N.L.,Abramowicz, H.,Abreu, H.,Abulaiti, Y.,Acharya, B.S.,Achkar, B.,Adachi, S.,Adam, L. North-Holland Pub. Co 2020 Physics letters. Section B Vol.801 No.-
<P><B>Abstract</B></P> <P>A search for long-lived particles decaying into an oppositely charged lepton pair, <I>μμ</I>, <I>ee</I>, or <I>eμ</I>, is presented using 32.8 <SUP> fb − 1 </SUP> of <I>pp</I> collision data collected at s = 13 TeV by the ATLAS detector at the LHC. Candidate leptons are required to form a vertex, within the inner tracking volume of ATLAS, displaced from the primary <I>pp</I> interaction region. No lepton pairs with an invariant mass greater than 12 GeV are observed, consistent with the background expectations derived from data. The detection efficiencies for generic resonances with lifetimes (<I>cτ</I>) of 100–1000 mm decaying into a dilepton pair with masses between 0.1–1.0 TeV are presented as a function of <SUB> p T </SUB> and decay radius of the resonances to allow the extraction of upper limits on the cross sections for theoretical models. The result is also interpreted in a supersymmetric model in which the lightest neutralino, produced via squark–antisquark production, decays into <SUP> ℓ + </SUP> <SUP> ℓ ′ − </SUP> ν ( ℓ , <SUP> ℓ ′ </SUP> = e , <I>μ</I>) with a finite lifetime due to the presence of R-parity violating couplings. Cross-section limits are presented for specific squark and neutralino masses. For a 700 GeV squark, neutralinos with masses of 50–500 GeV and mean proper lifetimes corresponding to <I>cτ</I> values between 1 mm to 6 m are excluded. For a 1.6 TeV squark, <I>cτ</I> values between 3 mm to 1 m are excluded for 1.3 TeV neutralinos.</P>
Darren B. Taichman,Joyce Backus,Christopher Baethge,Howard Bauchner,Annette Flanagin,Fernando Florenzano,Frank A. Frizelle,Fiona Godlee,Laragh Gollogly,Abraham Haileamlak,Sung-Tae Hong,Richard Horton 대한의학회 2020 Journal of Korean medical science Vol.35 No.4
Many factors, including professional and personal relationships and activities, can influence the design, conduct, and reporting of the clinical science that informs health care decision. The potential for conflict of interest exists when these relationships and activities may bias judgement.1 Many stakeholders—editors, peer reviewers, clinicians, educators, policymakers, patients, and the public—rely on the disclosure of authors' relationships and activities to inform their assessments. Trust in the transparency, consistency, and completeness of these disclosures is essential.
Miller-Rushing, Abraham J.,Katsuki, Toshio,Primack, Richard B.,Ishii, Yukio,Lee, Sang Don,Higuchi, Hiroyoshi Botanical Society of America, Inc. (Columbus) * Bu 2007 American journal of botany Vol.94 No.9
<P>Climate change is affecting plant phenology worldwide. Phenological responses vary among species, but it is not clear how responses differ among closely related species. We examined a 25-yr record (1981-2005) of flowering times for 97 trees, representing 17 species and hybrids of cherry (Cerasus sp. or Prunus sp.) grown at Mt. Takao, in Tokyo, Japan. The cherry trees flowered earlier over time, by an average of 5.5 d over the 25-yr study. Earlier flowering was explained largely by a 1.8C increase in February-March mean monthly temperatures. Most species and hybrids flowered 3-5 d earlier for each 1C increase in temperature, but early-flowering taxa flowered as much as 9 d earlier for each 1C increase in temperature. Flowering durations and differences in flowering times among species were greater in warm years than in cold years. Species and individual trees also flowered longer in warm years. These results show that the flowering times of closely related species may change similarly in response to climate change, but that early-flowering species may diverge from the overall trend in a predictable way. Such changes in flowering may affect gene flow and pollination as the length of the flowering season increases.</P>
Predictors of Esophageal Stricture Formation Post Endoscopic Mucosal Resection
Bashar Qumseya,Abraham M. Panossian,Cynthia Rizk,David Cangemi,Christianne Wolfsen,Massimo Raimondo,Timothy Woodward,Michael B. Wallace,Herbert Wolfsen 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.2
Background/Aims: Stricture formation is a common complication after endoscopic mucosal resection. Predictors of stricture formationhave not been well studied. Methods: We conducted a retrospective, observational, descriptive study by using a prospective endoscopic mucosal resection databasein a tertiary referral center. For each patient, we extracted the age, sex, lesion size, use of ablative therapy, and detection of esophagealstrictures. The primary outcome was the presence of esophageal stricture at follow-up. Multivariate logistic regression was used to analyzethe association between the primary outcome and predictors. Results: Of 136 patients, 27% (n=37) had esophageal strictures. Thirty-two percent (n=44) needed endoscopic dilation to relieve dysphagia(median, 2; range, 1 to 8). Multivariate logistic regression analysis showed that the size of the lesion excised is associated with increasedodds of having a stricture (odds ratio, 1.6; 95% confidence interval, 1.1 to 2.3; p=0.01), when controlling for age, sex, and ablativemodalities. Similarly, the number of lesions removed in the index procedure was associated with increased odds of developing a stricture(odds ratio, 2.3; 95% confidence interval, 1.3 to 4.2; p=0.007). Conclusions: Stricture formation after esophageal endoscopic mucosal resection is common. Risk factors for stricture formation includelarge mucosal resections and the resection of multiple lesions on the initial procedure.