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RISS 인기검색어
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- 저자 : Azadeh Asefnejad (검색결과 2 건)
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Parastoo Namdarian,Ali Zamanian,Azadeh Asefnejad,Maryam Saeidifar 한국고분자학회 2018 폴리머 Vol.42 No.6
Bone tissue engineering is now used as an alternative for the treatment of bone-related diseases. In this study, chitosan-gelatin scaffold with olibanum microspheres containing dexamethasone has been produced by the freeze-drying method. SEM and FTIR were used to characterize the scaffolds synthesized. The rate of drug release from these scaffolds was measured by a UV spectrophotometer. The synthesized scaffold was measured in terms of the swelling and degradation rates. In vitro studies were conducted to evaluate bioactivity and the environmental compatibility of the scaffold with an MTT test. A good controlled release was achieved. The bioactivity analysis confirmed the formation of apatite. The results of the MTT test showed that the synthesized scaffold was biocompatible and had an appropriate interaction with the cell. The results showed that the produced scaffold had the properties necessary to regenerate and repair bones.
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Shahin Foroutan,Mohammad Hashemian,Mehdi Khosravi,Mazyar Ghadiri Nejad,Azadeh Asefnejad,Saeed Saber-Samandari,Amirsalar Khandan 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2
Bone regeneration is a growing and relatively effective treatment in most bone disease treatments. Adverse effectsassociated with conventional transplantation techniques have led to advanced bone tissue engineering. The purpose of thisstudy is to produce a bone scaffold, made of sodium alginate (Na-Alg) based scaffold, with the addition of wollastonitegraphenenanosheet (WS-GS) with similar mechanical properties to normal bone. First, the Na-Alg-WS-GS nanocompositesare fabricated using freeze-drying technique in which GS is used as additives with different weight percentages (0, 1, 2 and3 wt%). The fabricated nanocomposite scaffolds are tested and analyzed by X-ray diffraction (XRD) and scanning electronmicroscopy (SEM) analyzes. The maximum tensile strength, lowest decrease in sample area and stress yield is tested usingmechanical testing. Then, the biological response in the biological environment, pH and weight changes after immersion insimulated body fluid (SBF) and phosphate buffered saline (PBS) is determined. The results show that the sample with 1 wt%GS has an appropriate capacity for reconstitution in the biological solution. The SEM shows an appropriate porosity of thescaffolds and a uniform distribution of GS in the polymeric matrix. The SEM images shows that as the amount of GSincreases, the swelling capacity of the nanocomposites rises, regarding the weak bonding of GS and polymeric matrix. Additional amount of GS leads to increase in the tensile strength with the sample containing 1 wt%, however increasing ofGS may decreases the mechanical performance of the structure. To gain the optimal combination of scaffold with the bestmechanical and biological properties, the Global Criterion Method (GCM) is utilized. The obtained results show that theprepared nanocomposites are suitable for further development in tissue engineering and can be suitable for the bonesubstitutes application with desirable mechanical performance.
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