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- 저자 : Ali Zamanian (검색결과 4 건)
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Parastoo Namdarian,Ali Zamanian,Azadeh Asefnejad,Maryam Saeidifar 한국고분자학회 2018 폴리머 Vol.42 No.6
Bone tissue engineering is now used as an alternative for the treatment of bone-related diseases. In this study, chitosan-gelatin scaffold with olibanum microspheres containing dexamethasone has been produced by the freeze-drying method. SEM and FTIR were used to characterize the scaffolds synthesized. The rate of drug release from these scaffolds was measured by a UV spectrophotometer. The synthesized scaffold was measured in terms of the swelling and degradation rates. In vitro studies were conducted to evaluate bioactivity and the environmental compatibility of the scaffold with an MTT test. A good controlled release was achieved. The bioactivity analysis confirmed the formation of apatite. The results of the MTT test showed that the synthesized scaffold was biocompatible and had an appropriate interaction with the cell. The results showed that the produced scaffold had the properties necessary to regenerate and repair bones.
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Coating of Laponite on PLA Nanofibrous for Bone Tissue Engineering Application
Zahra Orafa,Shiva Irani,Ali Zamanian,Hadi Bakhshi,Habib Nikukar,Behafarid Ghalandari 한국고분자학회 2021 Macromolecular Research Vol.29 No.3
In this study, electrospun polylactic acid (PLA) nanofibers were coated with osteoinductive Laponite (LAP) nanoplatelets and used as scaffolds for bone tissue engineering. The LAP nanoplatelets were physically crosslinked with high molecular weight polyethylene oxide (PEO) to make a layer of LAP/PEO network around PLA nanofibers with a thickness of 45-175 nm that was controllable through adjusting the concentration of the LAP/PEO solution (0.4, 0.8, and 1.2 wt%). The LAP/PEO layer improved the surface hydrophilicity (water contact angle from 111° to 26°) and thus the cell attachment and proliferation (p ≤ 0.05) by the scaffolds. The LAP nanoplatelets coated on the surface of PLA nanofibers could induce osteodifferentiation on human mesenchymal stem cells (hMSCs) by increasing the ALKALINE PHOSPHATASE (ALP) activity. The expression of specific osteogenic genes (ALP and OSTEONECTIN) at the transcription level (p ≤ 0.001) for the seeded hMSCs proved the osteoinductive effect of coated LAP nanoplatelets for the differentiation of stem cells to osteoblasts without using any external osteogenic inducers. The LAP-coated nanofibers can be used as an excellent scaffold for bone tissue engineering to provide an appropriate environment for direct bone tissue engineering.
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Taheri-Kharameh, Zahra,Noorizadeh, Farsad,Sangy, Samira,Zamanian, Hadi,Shouri-Bidgoli, Ali Reza,Oveisi, Helaleh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: Colorectal cancer is one of the most common neoplasms in Iran. Secondary prevention (colorectal cancer screening) is important and a most valuable method of early diagnosis of this cancer. The objectives of this study were to determine the factors associated with colorectal cancer screening adherence among Iranians 50 years and older using the Health Belief Model. Materials and Methods: This cross-sectional study was conducted from June 2012 to May 2013. A convenience sample of 200 individuals aged 50 and older was recruited from the population at outpatient clinics in teaching hospitals. Data gathering tools were the Champions health belief model scale (CHBMS) with coverage of socio-demographic background and CRC screening information. Multiple logistic regression was performed to identify factors associated with colorectal cancer screening adherence. Results: The mean age of participants was $62.5{\pm}10.8$ and 75.5% were women. A high percentage of the participants had not heard or read about colorectal cancer (86.5%) and CRC screening (93.5%). Perceived susceptibility to colorectal cancer had the lowest percentage of all of the subscales. Participants who perceived more susceptibility (OR =2.99; CI 95%: 1.23-5.45) and reported higher knowledge (OR =1.29; CI 95%: 1.86-3.40) and those who reported fewer barriers (OR =.37; CI 95%:.21-.89), were more likely to have carried out colorectal cancer screening. Conclusions: Our findings indicated that CRC knowledge, perceived susceptibility and barriers were significant predictors of colorectal cancer screening adherence. Strategies to increase knowledge and overcome barriers in risk individuals appear necessary. Education programs should be promoted to overcome knowledge deficiency and negative perceptions in elderly Iranians.
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Farhad Sobouti,Vahid Rakhshan,Mahdi Gholamrezaei Saravi,Ali Zamanian,Mahsa Shariati 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.2
Objective: Traditional retainers (both metal and fiber-reinforced composite [FRC]) have limitations, and a retainer made from more flexible ligature wires might be advantageous. We aimed to compare an experimental design with two traditional retainers. Methods: In this prospective preliminary clinical trial, 150 post-treatment patients were enrolled and randomly divided into three groups of 50 patients each to receive mandibular canine-to-canine retainers made of FRC, flexible spiral wire (FSW), and twisted wire (TW). The patients were monitored monthly. The time at which the first signs of breakage/debonding were detected was recorded. The success rates of the retainers were compared using chi-squared, Kaplan-Meier, and Cox proportional-hazard regression analyses (α = 0.05). Results: In total, 42 patients in the FRC group, 41 in the FSW group, and 45 in the TW group completed the study. The 2-year failure rates were 35.7% in the FRC group, 26.8% in the FSW group, and 17.8% in the TW group. These rates differed insignificantly (chi-squared p = 0.167). According to the Kaplan-Meier analysis, failure occurred at 19.95 months in the FRC group, 21.37 months in the FSW group, and 22.36 months in the TW group. The differences between the survival rates in the three groups were not significant (Cox regression p = 0.146). Conclusions: Although the failure rate of the experimental retainer was two times lower than that of the FRC retainer, the difference was not statistically significant. The experimental TW retainer was successful, and larger studies are warranted to verify these results.
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