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- 저자 : Shahin Foroutan (검색결과 1 건)
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Shahin Foroutan,Mohammad Hashemian,Mehdi Khosravi,Mazyar Ghadiri Nejad,Azadeh Asefnejad,Saeed Saber-Samandari,Amirsalar Khandan 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2
Bone regeneration is a growing and relatively effective treatment in most bone disease treatments. Adverse effectsassociated with conventional transplantation techniques have led to advanced bone tissue engineering. The purpose of thisstudy is to produce a bone scaffold, made of sodium alginate (Na-Alg) based scaffold, with the addition of wollastonitegraphenenanosheet (WS-GS) with similar mechanical properties to normal bone. First, the Na-Alg-WS-GS nanocompositesare fabricated using freeze-drying technique in which GS is used as additives with different weight percentages (0, 1, 2 and3 wt%). The fabricated nanocomposite scaffolds are tested and analyzed by X-ray diffraction (XRD) and scanning electronmicroscopy (SEM) analyzes. The maximum tensile strength, lowest decrease in sample area and stress yield is tested usingmechanical testing. Then, the biological response in the biological environment, pH and weight changes after immersion insimulated body fluid (SBF) and phosphate buffered saline (PBS) is determined. The results show that the sample with 1 wt%GS has an appropriate capacity for reconstitution in the biological solution. The SEM shows an appropriate porosity of thescaffolds and a uniform distribution of GS in the polymeric matrix. The SEM images shows that as the amount of GSincreases, the swelling capacity of the nanocomposites rises, regarding the weak bonding of GS and polymeric matrix. Additional amount of GS leads to increase in the tensile strength with the sample containing 1 wt%, however increasing ofGS may decreases the mechanical performance of the structure. To gain the optimal combination of scaffold with the bestmechanical and biological properties, the Global Criterion Method (GCM) is utilized. The obtained results show that theprepared nanocomposites are suitable for further development in tissue engineering and can be suitable for the bonesubstitutes application with desirable mechanical performance.
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