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Characterizations of nano-zinc doped hydroxyapatite to use as bone tissue engineering
Abdel-Ghany, Basma E.,Abdel-Hady, Bothaina M.,El-Kady, Abeer M.,Beheiry, Hanan H.,Guirguis, Osiris W. Techno-Press 2015 Advances in materials research Vol.4 No.4
Contamination by bacterial strands is a major problem after bone replacement surgeries, so there is a great need to develop low cost biocompatible antibacterial bioactive scaffolds to be used in bone tissue engineering. For this purpose, nano-zinc doped hydroxyapatite with different zinc-concentrations (5, 10 and 15 mol%) was successfully prepared by the wet chemical precipitation method. The prepared powders were used to form porous scaffolds containing biodegradable Ca-cross-linked alginate (5%) in order to enhance the properties of alginate scaffolds. The scaffolds were prepared using the freeze-gelation method. The prepared powders were tested by X-ray diffraction; transmission electron microscope and Fourier transform infrared analyses, while the prepared scaffolds were investigated by Fourier transform infrared analyses, thermogravimetric analyses and measurement of the antibacterial properties. Best results were obtained from scaffold containing 15% mol zinc-doped hydroxyapatite powders and 5% alginate concentration with ratio of 70:30.
Abdel-Ghani Boudjahem,Afef Redjel,Tahar Mokrane 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.1
Palladium nanoparticles supported on silica were prepared by hydrazine reduction in aqueous medium at room temperature. They were characterized by XRD, TEM, EDX, H2-adsorption, and H2-TPD. The catalytic properties were evaluated in the gas-phase hydrogenation of benzene in the temperature range of 75–250 8C. Metal particles with a size range of 4.0–25.8 nm were obtained. The metal surface area and hydrogen storage increase with decreasing metal particle size. The H2-TPD profiles exhibited a main peak appeared at 540 8C with two shoulders at lower (445 8C) and higher (605 8C) temperatures. These peaks were ascribed to strongly adsorbed hydrogen on the surface catalyst. The catalytic activity of the catalysts strongly depends on the metal loading. It increases with decreasing Pd loading. This is ascribed to metal surface area, which increases with decreasing Pd content.
Abdel-Ghany F. Shoair 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.10
The synthesis and characterization of K3[Ru(C2O4)3]•4H2O (C2O42 = oxalato anoin) complex are described, and its redox properties (in buffer solution of pH = 12) have been investigated. This complex is used for in situ generation of oxoruthenates complexes which have been characterized by electronic spectroscopy. Reaction of K3[Ru(C2O4)3]•4H2O with excess S2O82 in molar KOH generates trans-[RuO3(OH)2]2/S2O82 reagent while with excess BrO3 in molar Na2CO3 generates [RuO4]/BrO3 reagent. Avoiding the direct use of [RuO4] the organic-soluble (n-Pr4N)+[RuO4], (TPAP) has been isolated by reaction of K3[Ru(C2O4)3]•4H2O with excess BrO3 in molar carbonate and n-Pr4NOH. In a mixture of H2O/CCl4 ruthenium tetraoxide can be generated by reaction of K3[Ru(C2O4)3]•4H2O with excess IO4. The catalytic activities of oxoruthenates that have been made from K3[Ru(C2O4)3]•4H2O towards the oxidation of benzyl alcohol, piperonyl alcohol, benzaldehyde and benzyl amine at room temperature have been studied.
Shoair, Abdel-Ghany F. Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.10
The synthesis and characterization of ${K_3[Ru(C_2O_4)3]{\cdot}4H_2O\;(C_2O_4}^{2-}$ = oxalato anoin) complex are described, and its redox properties (in buffer solution of pH = 12) have been investigated. This complex is used for in situ generation of oxoruthenates complexes which have been characterized by electronic spectroscopy. Reaction of ${K_3[Ru(C_2O_4)3]{\cdot}4H_2O$ with excess ${S_2O_8}^{2-}$ in molar KOH generates trans-${[RuO_3(OH)_2]^{2-}/S_2O_8}^{2-}$ reagent while with excess ${BrO_3}^-$ in molar $Na_2CO_3$ generates ${[RuO_4]^-/BrO_3}^-$ reagent. Avoiding the direct use of [$RuO_4$] the organic-soluble $(n-Pr_4N)^+[RuO_4]^-$, (TPAP) has been isolated by reaction of $K_3[Ru(C_2O_4)3]{\cdot}4H_2O$ with excess ${BrO_3}^-$ in molar carbonate and n-$Pr_4$NOH. In a mixture of $H_2O/CCl_4$ ruthenium tetraoxide can be generated by reaction of $K_3[Ru(C_2O_4)3]{\cdot}4H_2O$ with excess ${IO_4}^-$. The catalytic activities of oxoruthenates that have been made from $K_3[Ru(C_2O_4)3]{\cdot}4H_2O$ towards the oxidation of benzyl alcohol, piperonyl alcohol, benzaldehyde and benzyl amine at room temperature have been studied.
Ali Elagamey, Abdel Ghani,Ahmed Sowellim, Salah Zaki,Mohamed Nabil, Khodeir The Pharmaceutical Society of Korea 1987 Archives of Pharmacal Research Vol.10 No.1
Several new imidazo [1, 2-b] pyrazole, pyrazolo [5, 1-c]-1, 2, 4-triazine and pyrazolo [5, 1-c] triazole derivatives were prepared from the reaction of 3-antipyrinyl-5-aminopyrazole or its diazonium salt with .alpha.-chloroacetyl derivatives.
Ali Elagamey, Abdel Ghani The Pharmaceutical Society of Korea 1987 Archives of Pharmacal Research Vol.10 No.3
Several new pyrazolo [1, 5-a]-S-triazine, pyrazolo [4, 5, -elpyrimidine, pyrazolo [1, 5-a] pyrimidine derivatives were synthesized via condensation of 3-antipyrinyl-5-amino-pyrazole (2) with $\beta$$-bifunctional reagents. The azo analogues of pyrazolo [1, 5-a] pyrimidines ; i. e. pyrazolo [5, 1, c]-as-triazine and pyrazolo[5, 1, -c]-as-benzotriazine were synthesized by coupling of diazotized 2-with agents containing active hydrogen.
El-Taweel, Fathy Mohamed Abdel-Aziz,Hadi-Mashaly, Mohamed-Abdel,Ali-Elagamey, Abdel-Ghani The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3
4-Arylazo-3-phenyl-5-aminopyrazoles (5a, b) and substituted hydroxythiazoles 8a, b were synthesized from the reaction of 4a, b with hydrazine hydrate and mercaptoacetic acid respectively. Compounds 5a, b and 8a, b were also obtained from coupling of 2a, b with 6 and 7, respectively. 4H-1, 4-Benzothiazine 11 was prepared from 1 and 10. The resaction of the diazonium salts 2a-c with diethyl 3-amino-2-cyanopenet-2-en-1, 5-dicarboxylate 12 was also reported.
Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model
Loutfy, Samah A,Al-Ansary, Nadia A,Abdel-Ghani, Nour T,Hamed, Ahmed R,Mohamed, Mona B,Craik, James D,Eldin, Taher A. Salah,Abdellah, Ahmed M,Hussein, Yassmein,Hasanin, MTM,Elbehairi, Serag Eldin I Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Aims: To investigate effect of metallic nanoparticles, silver (AgNPs) and gold nanoparticles (AuNPs) as antitumor treatment in vitro against human breast cancer cells (MCF-7) and their associated mechanisms. This could provide new class of engineered nanoparticles with desired physicochemical properties and may present newer approaches for therapeutic modalities to breast cancer in women. Materials and Methods: A human breast cancer cell line (MCF-7) was used as a model of cells. Metallic nanoparticles were characterized using UV-visible spectra and transmission electron microscopy (TEM). Cytotoxic effects of metallic nanoparticles on MCF-7 cells were followed by colorimetric SRB cell viability assays, microscopy, and cellular uptake. Nature of cell death was further investigated by DNA analysis and flow cytometry. Results: Treatment of MCF-7 with different concentrations of 5-10nm diameter of AgNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $6.28{\mu}M$, whereas treatment of MCF-7 with different concentrations of 13-15nm diameter of AuNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $14.48{\mu}M$. Treatment of cells with a IC50 concentration of AgNPs generated progressive accumulation of cells in the S phase of the cell cycle and prevented entry into the M phase. The treatment of cells with IC50 concentrations of AuNPs similarly generated progressive accumulation of cells in sub-G1 and S phase, and inhibited the entrance of cells into the M phase of the cell cycle. DNA fragmentation, as demonstrated by electrophoresis, indicated induction of apoptosis. Conclusions: Our engineered silver nanoparticles effectively inhibit the proliferation of human breast carcinoma cell line MCF-7 in vitro at high concentration ($1000{\mu}M$) through apoptotic mechanisms, and may be a beneficial agent against human carcinoma but further detailed study is still needed.
Asmaa M. Arafa,Afaf E. Abdel-Ghany,Samih I. El-Dahmy,Sahar Abdelaziz,Yassin El-Ayouty,Ashraf S. A. El-Sayed 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.4
Phenylalanine ammonia-lyase (PAL) catalyzes the reversible deamination of phenylalanine to cinnamic acid and ammonia. Algae have been considered as biofactories for PAL production, however, biochemical characterization of PAL and its potency for myristicin biotransformation into MMDA (3-methoxy-4, 5-methylenedioxyamphetamine) has not been studied yet. Thus, PAL from Anabaena flos-aquae and Spirulina platensis has been purified, comparatively characterized and its affinity to transform myristicin was assessed. The specific activity of purified PAL from S. platensis (73.9 μmol/mg/min) and A. flos-aquae (30.5 μmol/mg/min) was increased by about 2.9 and 2.4 folds by gel-filtration comparing to their corresponding crude enzymes. Under denaturing-PAGE, a single proteineous band with a molecular mass of 64 kDa appeared for A. flos-aquae and S. platensis PAL. The biochemical properties of the purified PAL from both algal isolates were determined comparatively. The optimum temperature of S. platensis and A. flos-aquae PAL for forward or reverse activity was reported at 30oC, while the optimum pH for PAL enzyme isolated from A. flos-aquae was 8.9 for forward and reverse activities, and S. platensis PAL had maximum activities at pH 8.9 and 8 for forward and reverse reactions, respectively. Luckily, the purified PALs have the affinity to hydroaminate the myristicin to MMDA successfully in one step. Furthermore, a successful method for synthesis of MMDA from myristicin in two steps was also established. Gas chromatography-mass spectrometry (GC-MS) analysis was conducted to track the product formation.
Ahmed Chaouki Megherbi,Hassina Megherbi,Khier Benmahammed,Abdel Ghani Aissaoui,Ahmed Tahour 대한전기학회 2010 Journal of Electrical Engineering & Technology Vol.5 No.4
This paper presents a contribution to parameter identification of a non-linear system using a new strategy to improve the genetic algorithm (GA) method. Since cost function plays an important role in GA-based parameter identification, we propose to improve the simple version of GA, where weights of the cost function are not taken as constant values, but varying along the procedure of parameter identification. This modified version of GA is applied to the induction motor (IM) as an example of nonlinear system. The GA cost function is the weighted sum of stator current and rotor speed errors between the plant and the model of induction motor. Simulation results show that the identification method based on improved GA is feasible and gives high precision.